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MeSH Review


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Disease relevance of Natriuresis


Psychiatry related information on Natriuresis


High impact information on Natriuresis


Chemical compound and disease context of Natriuresis


Biological context of Natriuresis


Anatomical context of Natriuresis


Associations of Natriuresis with chemical compounds

  • Treatment of SHRs and WKYs with stannous chloride (SnCl2), which selectively depletes renal cytochrome P-450, restored BP to normal, coincident with a natriuresis, in young but not in adult SHRs and did not affect either BP or sodium excretion in WKYs [27].
  • One notable exception, however, consists of the osmotic control of electrical activity in SON neurons which, in the rat, contributes to the regulation of natriuresis and diuresis through effects on the secretion of oxytocin and vasopressin [28].
  • The adaptive increased natriuresis per nephron exhibited by the control animals was prevented in the PRNa animals [29].
  • Dopamine and D1 agonists and NE all increase phosphatidyl inositol-specific phospholipase C (PLC) activity, but whereas dopamine produces a natriuresis, NE has an antinatriuretic effect [30].
  • Our results indicate that the diuretic and natriuretic effects are exerted at distinct sites, with only the natriuresis being related to an increase of extracellular cGMP [31].

Gene context of Natriuresis

  • Novel analog of atrial natriuretic peptide selective for receptor-A produces increased diuresis and natriuresis in rats [32].
  • Ang II infusion normally promotes natriuresis and diuresis, but COX2 deficiency blocked this effect [33].
  • Within the first hour, CRH caused antidiuresis, antinatriuresis, and antikaliuresis together with reduction in urinary cGMP output that, in the fourth hour, were replaced by diuresis, natriuresis, and kaliuresis accompanied by increased cGMP output [34].
  • Thus, activation of the CXCR3 receptor in proximal tubular cells might disturb natriuresis during inflammatory and ischemic kidney disease via EGR-1-mediated imbalance of ROS [35].
  • Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor [36].

Analytical, diagnostic and therapeutic context of Natriuresis


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  21. Dopamine acutely stimulates Na+/H+ exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylation. Hu, M.C., Fan, L., Crowder, L.A., Karim-Jimenez, Z., Murer, H., Moe, O.W. J. Biol. Chem. (2001) [Pubmed]
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  31. Dissociation of natriuresis and diuresis and heterogeneity of the effector system of atrial natriuretic factor in rats. Willenbrock, R.C., Tremblay, J., Garcia, R., Hamet, P. J. Clin. Invest. (1989) [Pubmed]
  32. Novel analog of atrial natriuretic peptide selective for receptor-A produces increased diuresis and natriuresis in rats. Jin, H., Li, B., Cunningham, B., Tom, J., Yang, R., Sehl, P., Thomas, G.R., Ko, A., Oare, D., Lowe, D.G. J. Clin. Invest. (1996) [Pubmed]
  33. Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. Qi, Z., Hao, C.M., Langenbach, R.I., Breyer, R.M., Redha, R., Morrow, J.D., Breyer, M.D. J. Clin. Invest. (2002) [Pubmed]
  34. Corticotropin-releasing hormone causes antidiuresis and antinatriuresis by stimulating vasopressin and inhibiting atrial natriuretic peptide release in male rats. Gutkowska, J., Jankowski, M., Mukaddam-Daher, S., McCann, S.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  35. Up-regulation of early growth response gene-1 via the CXCR3 receptor induces reactive oxygen species and inhibits Na+/K+-ATPase activity in an immortalized human proximal tubule cell line. Bek, M.J., Reinhardt, H.C., Fischer, K.G., Hirsch, J.R., Hupfer, C., Dayal, E., Pavenstädt, H. J. Immunol. (2003) [Pubmed]
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