Chemical Compound Review:
Tolylene diisocyanate 2,4-diisocyanato-1-methyl- benzene
Synonyms:
Hylene T, Nacconate IOO, Mondur TD, TDI-80, Desmodur T80, ...
- Toluene diisocyanate (TDI) pulmonary disease: immunologic and inhalation challenge studies. Butcher, B.T., Salvaggio, J.E., Weill, H., Ziskind, M.M. J. Allergy Clin. Immunol. (1976)
- Airway wall remodeling after cessation of exposure to isocyanates in sensitized asthmatic subjects. Saetta, M., Maestrelli, P., Turato, G., Mapp, C.E., Milani, G., Pivirotto, F., Fabbri, L.M., Di Stefano, A. Am. J. Respir. Crit. Care Med. (1995)
- Preparation and use of erythrocyte-globulin conjugates to Lassa virus in reversed passive hemagglutination and inhibition. Goldwasser, R.A., Elliott, L.H., Johnson, K.M. J. Clin. Microbiol. (1980)
- Dermal contact with toluene diisocyanate (TDI) produces respiratory tract hypersensitivity in guinea pigs. Karol, M.H., Hauth, B.A., Riley, E.J., Magreni, C.M. Toxicol. Appl. Pharmacol. (1981)
- Tumor necrosis factor inhibits a polymorphonuclear leukocyte-dependent airway edema in guinea pigs. Gordon, T., Sheppard, D. J. Appl. Physiol. (1988)
- Human leukocyte antigen associations in occupational asthma induced by isocyanates. Mapp, C.E., Balboni, A., Baricordi, R., Fabbri, L.M. Am. J. Respir. Crit. Care Med. (1997)
- Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies. Emini, E.A., Jameson, B.A., Lewis, A.J., Larsen, G.R., Wimmer, E. J. Virol. (1982)
- N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk. Wikman, H., Piirilä, P., Rosenberg, C., Luukkonen, R., Kääriä, K., Nordman, H., Norppa, H., Vainio, H., Hirvonen, A. Pharmacogenetics (2002)
- Neutrophil activation following TDI bronchial challenges to the airway secretion from subjects with TDI-induced asthma. Park, H., Jung, K., Kim, H., Nahm, D., Kang, K. Clin. Exp. Allergy (1999)
- Effects of cilomilast on dendritic cell function in contact sensitivity and dendritic cell migration through skin. Bäumer, W., Tschernig, T., Sülzle, B., Seegers, U., Lührmann, A., Kietzmann, M. Eur. J. Pharmacol. (2003)
- Pharmacological profile of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on acute and chronic inflammation models. Yamamoto, S., Sugahara, S., Ikeda, K., Shimizu, Y. Eur. J. Pharmacol. (2006)
- A murine model for assessing the respiratory hypersensitivity potential of chemical allergens. Satoh, T., Kramarik, J.A., Tollerud, D.J., Karol, M.H. Toxicol. Lett. (1995)
- Inhibition by 2,4-toluene diisocyanate of the calcium signaling of neuronal nicotinic acetylcholine receptors in human neuroblastoma SH-SY5Y cells. Chiung, Y.M., Kao, Y.Y., Chen, H.T., Liu, P.S. J. Biomed. Sci. (2005)
- TDI-induced oculorhinitis and bronchial asthma. Paggiaro, P.L., Rossi, O., Lastrucci, L., Pardi, F., Pezzini, A., Baschieri, L. Journal of occupational medicine. : official publication of the Industrial Medical Association. (1985)
- Determination of toluenediamines in urine of workers occupationally exposed to isocyanates by high-performance liquid chromatography. Carbonnelle, P., Boukortt, S., Lison, D., Buchet, J.P. The Analyst. (1996)
- Toxicologic considerations in the diagnosis of occupational asthma. Waddell, W.J. Ann. Allergy Asthma Immunol. (1999)
- HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced occupational asthma? Kim, S.H., Oh, H.B., Lee, K.W., Shin, E.S., Kim, C.W., Hong, C.S., Nahm, D.H., Park, H.S. Allergy (2006)
- Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. III. Results with 27 chemicals. Gulati, D.K., Witt, K., Anderson, B., Zeiger, E., Shelby, M.D. Environ. Mol. Mutagen. (1989)
- Histamine content, synthesis and degradation in nasal mucosa and lung of guinea-pigs treated with toluene diisocyanate (TDI). Abe, Y., Ogino, S., Irifune, M., Imamura, I., Liu, Y.Q., Fukui, H., Matsunaga, T. Clin. Exp. Allergy (1993)
- In vivo and in vitro reactions of toluene diisocyanate isomers with guinea pig hemoglobin. Day, B.W., Jin, R., Karol, M.H. Chem. Res. Toxicol. (1996)
- Role of inhalation challenge testing in the diagnosis of isocyanate-induced asthma. Banks, D.E., Sastre, J., Butcher, B.T., Ellis, E., Rando, R.J., Barkman, H.W., Hammad, Y.Y., Glindmeyer, H.W., Weill, H. Chest (1989)
- Two-generation reproductive toxicity study of inhaled toluene diisocyanate vapor in CD rats. Tyl, R.W., Neeper-Bradley, T.L., Fisher, L.C., Dodd, D.E., Pritts, I.M., Losco, P.E., Lyon, J.P., Landry, T.D. Toxicol. Sci. (1999)
- Validity of methods to predict the respiratory sensitizing potential of chemicals: A study with a piperidinyl chlorotriazine derivative that caused an outbreak of occupational asthma. Vanoirbeek, J.A., Mandervelt, C., Cunningham, A.R., Hoet, P.H., Xu, H., Vanhooren, H.M., Nemery, B. Toxicol. Sci. (2003)
- A method using toluene-2,4-diisocyanate and glutaraldehyde to stabilize and conjugate antigens to erythrocytes for use in passive hemagglutination tests. Mahan, D.E., Copeland, R.L. J. Immunol. Methods (1978)
- Need for monitoring nonspecific bronchial hyperresponsiveness before and after isocyanate inhalation challenge. Sastre, J., Fernández-Nieto, M., Novalbos, A., De Las Heras, M., Cuesta, J., Quirce, S. Chest (2003)
- Toluene diisocyanate (TDI) induces production of inflammatory cytokines and chemokines by bronchial epithelial cells via the epidermal growth factor receptor and p38 mitogen-activated protein kinase pathways. Ogawa, H., Inoue, S., Ogushi, F., Ogura, H., Nakamura, Y. Exp. Lung Res. (2006)
- Exposure to toluene diisocyanate (TDI) induces IL-8 production from bronchial epithelial cells: effect of pro-inflammatory cytokines. Lee, Y.M., Kim, H.A., Park, H.S., Lee, S.K., Nahm, D.H. J. Korean Med. Sci. (2003)
- Expression of interleukin (IL)-4 and IL-5 proteins in asthma induced by toluene diisocyanate (TDI). Maestrelli, P., Occari, P., Turato, G., Papiris, S.A., Di Stefano, A., Mapp, C.E., Milani, G.F., Fabbri, L.M., Saetta, M. Clin. Exp. Allergy (1997)
- TDI can induce respiratory allergy with Th2-dominated response in mice. Ban, M., Morel, G., Langonné, I., Huguet, N., Pépin, E., Binet, S. Toxicology (2006)
- Evaluation of self-reported skin problems among workers exposed to toluene diisocyanate (TDI) at a foam manufacturing facility. Daftarian, H.S., Lushniak, B.D., Reh, C.M., Lewis, D.M. J. Occup. Environ. Med. (2002)
- Cilomilast, tacrolimus and rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis. Bäumer, W., Sülzle, B., Weigt, H., De Vries, V.C., Hecht, M., Tschernig, T., Kietzmann, M. Br. J. Dermatol. (2005)
- Accelerated loss of FEV- in polyurethane production workers: a four-year prospective study. Wegman, D.H., Musk, A.W., Main, D.M., Pagnotto, L.D. Am. J. Ind. Med. (1982)
- Cellular and mediator profile in bronchoalveolar lavage of guinea pigs after toluene diisocyanate (TDI) exposure. Raulf, M., Tennie, L., Marczynski, B., Potthast, J., Marek, W., Baur, X. Lung (1995)