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Chemical Compound Review

TMAN     1,3-dioxoisobenzofuran-5- carboxylic acid

Synonyms: B4600_ALDRICH, AC-811, CCRIS 6282, LS-215, NCI-C56633, ...
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Disease relevance of Trimellitic anhydride-dendrimers


Psychiatry related information on Trimellitic anhydride-dendrimers


High impact information on Trimellitic anhydride-dendrimers

  • Human antihapten antibodies in trimellitic anhydride inhalation reactions. Immunoglobulin classes of anti-trimellitic anhydride antibodies and hapten inhibition studies [7].
  • Thus, TMA-exposed dendritic cells that have been conditioned in vivo with IL-10 (a potent inhibitor of the type 1-polarizing cytokine IL-12) are effective APCs for the development of a Th2-type response [8].
  • Associated with this, TMA provoked LC migration with delayed kinetics compared with DNCB, and local neutralization of IL-10 caused enhanced LC mobilization in response to TMA with concomitant up-regulation of cutaneous IL-1beta [8].
  • This was demonstrated by the marked reduction in histamine release if IgE was removed from the leukocytes before TMA treatment and challenge and also by activation of release from untreated cells by passive sensitization with TM-IgE before challenge [9].
  • The most relevant site of TMA modification of the basophil was receptor-bound IgE [9].

Chemical compound and disease context of Trimellitic anhydride-dendrimers


Biological context of Trimellitic anhydride-dendrimers


Anatomical context of Trimellitic anhydride-dendrimers


Associations of Trimellitic anhydride-dendrimers with other chemical compounds


Gene context of Trimellitic anhydride-dendrimers

  • The low levels of IFN-gamma induced by treatment with TMA or MDI were associated largely or wholly with CD8+ cells [25].
  • In addition, spontaneous IL-10 production by TMA-activated LNC was significantly higher than by cells prepared from oxazolone-exposed animals [21].
  • In the 'longer' assay, TMA exposure resulted in Con A induced IL-4 production whereas DNCB exposure did not [26].
  • Variation of TMA dose during both exposures similarly induced Th2 cytokines [27].
  • Draining LNC from OX-treated rats expressed elevated IFN-gamma mRNA, whereas those from TMA-treated rats expressed elevated IL-5 mRNA compared to controls [28].

Analytical, diagnostic and therapeutic context of Trimellitic anhydride-dendrimers


  1. An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile. Schottelius, A.J., Giesen, C., Asadullah, K., Fierro, I.M., Colgan, S.P., Bauman, J., Guilford, W., Perez, H.D., Parkinson, J.F. J. Immunol. (2002) [Pubmed]
  2. Trimellitic anhydride Toxicity. A cause of acute multisystem failure. Rivera, M., Nicotra, M.B., Byron, G.E., Patterson, R., Yawn, D.H., Franco, M., Zeiss, C.R., Greenberg, S.D. Arch. Intern. Med. (1981) [Pubmed]
  3. Lung injury induced by short-term intermittent trimellitic anhydride (TMA) inhalation. Zeiss, C.R., Leach, C.L., Levitz, D., Hatoum, N.S., Garvin, P.J., Patterson, R. J. Allergy Clin. Immunol. (1989) [Pubmed]
  4. Trimellitic anhydride-induced eosinophilia in a mouse model of occupational asthma. Regal, J.F., Mohrman, M.E., Sailstad, D.M. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  5. Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice. Farraj, A.K., Harkema, J.R., Kaminski, N.E. Toxicol. Sci. (2004) [Pubmed]
  6. Trimellitic anhydride (TMA) dust induces airway obstruction and eosinophilia in non-sensitized guinea pigs. Larsen, C.P., Regal, J.F. Toxicology (2002) [Pubmed]
  7. Human antihapten antibodies in trimellitic anhydride inhalation reactions. Immunoglobulin classes of anti-trimellitic anhydride antibodies and hapten inhibition studies. Patterson, R., Zeiss, C.R., Roberts, M., Pruzansky, J.J., Wolkonsky, P., Chacon, R. J. Clin. Invest. (1978) [Pubmed]
  8. Impact of cutaneous IL-10 on resident epidermal Langerhans' cells and the development of polarized immune responses. Cumberbatch, M., Clelland, K., Dearman, R.J., Kimber, I. J. Immunol. (2005) [Pubmed]
  9. Hapten-modified basophils: a model of human immediate hypersensitivity that can be elicited by IgG antibody. Akiyama, K., Pruzansky, J.J., Patterson, R. J. Immunol. (1984) [Pubmed]
  10. Differential ability of occupational chemical contact and respiratory allergens to cause immediate and delayed dermal hypersensitivity reactions in mice. Dearman, R.J., Mitchell, J.A., Basketter, D.A., Kimber, I. Int. Arch. Allergy Immunol. (1992) [Pubmed]
  11. Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma. Greene, A.L., Rutherford, M.S., Regal, R.R., Flickinger, G.H., Hendrickson, J.A., Giulivi, C., Mohrman, M.E., Fraser, D.G., Regal, J.F. Toxicol. Sci. (2005) [Pubmed]
  12. Antibody response to trimellityl hemoglobin in trimellitic anhydride-induced lung injury. Pien, L.C., Zeiss, C.R., Leach, C.L., Hatoum, N.S., Levitz, D., Garvin, P.J., Patterson, R. J. Allergy Clin. Immunol. (1988) [Pubmed]
  13. Immunology and immunopathology of trimellitic anhydride pulmonary reactions. Patterson, R., Zeiss, C.R., Pruzansky, J.J. J. Allergy Clin. Immunol. (1982) [Pubmed]
  14. Selective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine polarization. Hopkins, J.E., Naisbitt, D.J., Kitteringham, N.R., Dearman, R.J., Kimber, I., Park, B.K. Chem. Res. Toxicol. (2005) [Pubmed]
  15. Neurogenic goblet cell secretion and bronchoconstriction in guinea pigs sensitised to trimellitic anhydride. Hayes, J.P., Kuo, H.P., Rohde, J.A., Newman Taylor, A.J., Barnes, P.J., Chung, K.F., Rogers, D.F. Eur. J. Pharmacol. (1995) [Pubmed]
  16. Alveolar macrophages have a dual role in a rat model for trimellitic anhydride-induced occupational asthma. Valstar, D.L., Schijf, M.A., Nijkamp, F.P., Storm, G., Arts, J.H., Kuper, C.F., Bloksma, N., Henricks, P.A. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  17. Localization of inhaled trimellitic anhydride to lung with a respiratory lymph node antibody secreting cell response. Zeiss, C.R., Hatoum, N.S., Ferguson, J., Trout, J., Levitz, D., Siddiqui, F., Henderson, J., Yermakoff, J., Patterson, R. J. Allergy Clin. Immunol. (1992) [Pubmed]
  18. Allergen-induced cytokine phenotypes in mice: role of CD4 and CD8 T cell populations. Dearman, R.J., Humphreys, N., Skinner, R.A., Kimber, I. Clin. Exp. Allergy (2005) [Pubmed]
  19. Divergent immune responses to respiratory and contact chemical allergens: antibody elicited by phthalic anhydride and oxazolone. Dearman, R.J., Kimber, I. Clin. Exp. Allergy (1992) [Pubmed]
  20. Topical application versus intranasal instillation: a qualitative comparison of the effect of the route of sensitization on trimellitic anhydride-induced allergic rhinitis in A/J mice. Farraj, A.K., Harkema, J.R., Kaminski, N.E. Toxicol. Sci. (2006) [Pubmed]
  21. Differential cytokine production following chronic exposure of mice to chemical respiratory and contact allergens. Dearman, R.J., Basketter, D.A., Kimber, I. Immunology (1995) [Pubmed]
  22. Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4. Vandebriel, R.J., De Jong, W.H., Spiekstra, S.W., Van Dijk, M., Fluitman, A., Garssen, J., Van Loveren, H. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  23. Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides. Dearman, R.J., Filby, A., Humphreys, I.R., Kimber, I. Journal of applied toxicology : JAT. (2002) [Pubmed]
  24. Topical cis-urocanic acid suppresses both induction and elicitation of contact hypersensitivity in BALB/C mice. Lauerma, A.I., Aioi, A., Maibach, H.I. Acta Derm. Venereol. (1995) [Pubmed]
  25. Contribution of CD4+ and CD8+ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens. Dearman, R.J., Moussavi, A., Kemeny, D.M., Kimber, I. Immunology (1996) [Pubmed]
  26. Impact of exposure duration by low molecular weight compounds on interferon-gamma and interleukin-4 mRNA expression and production in the draining lymph nodes of mice. Vandebriel, R.J., De Jong, W.H., Hendriks, J.J., Van Loveren, H. Toxicology (2003) [Pubmed]
  27. Cytokine profiling for chemical sensitizers: application of the ribonuclease protection assay and effect of dose. Plitnick, L.M., Loveless, S.E., Ladics, G.S., Holsapple, M.P., Selgrade, M.J., Sailstad, D.M., Smialowicz, R.J. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
  28. Selectivity of IgE responses, mast cell sensitization, and cytokine expression in the immune response of Brown Norway rats to chemical allergens. Vento, K.L., Dearman, R.J., Kimber, I., Basketter, D.A., Coleman, J.W. Cell. Immunol. (1996) [Pubmed]
  29. Syndromes in workers exposed to trimellitic anhydride. A longitudinal clinical and immunologic study. Zeiss, C.R., Wolkonsky, P., Chacon, R., Tuntland, P.A., Levitz, D., Prunzansky, J.J., Patterson, R. Ann. Intern. Med. (1983) [Pubmed]
  30. Use of haptenizing ELISA to evaluate respiratory disease in a worker exposed to capacitor-coating powder. Paterson, B., Grammer, L.C., Ekberg, N.L., Patterson, R. J. Allergy Clin. Immunol. (1986) [Pubmed]
  31. Levels and specificity of antibody in bronchoalveolar lavage (BAL) and serum in an animal model of trimellitic anhydride-induced lung injury. Chandler, M.J., Zeiss, C.R., Leach, C.L., Hatoum, N.S., Levitz, D., Garvin, P.J., Patterson, R. J. Allergy Clin. Immunol. (1987) [Pubmed]
  32. Utility of antibody in identifying individuals who have or will develop anhydride-induced respiratory disease. Grammer, L., Shaughnessy, M., Kenamore, B. Chest (1998) [Pubmed]
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