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Chemical Compound Review:

AC1L2LYD 1-(2-chloroethyl)-4-[1-(2- chloroethyl)-4...

Synonyms: LS-44579, BRN 0133829, 5857-53-4, 6802-93-3, Bipiperidyl mustard, ...

Hopper, D.L. et al., Scallet, A.C. et al., Levine, S. et al., Laughton, W. et al., Wise, A., et al.

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Disease relevance of Bipiperidyl mustard

Administration of goldthioglucose (GTG) or bipiperidyl mustard (BPM) causes obesity and lesions in hypothalamus, medulla, and other regions of the brain [1].
Following a 48 h fasting period after hatching, male Cobb broiler chicks were injected with either bipiperidyl mustard (intraperitoneally; 0.01 and 0.02 mg/g body weight) or goldthioglucose (intracardially; 0.25 mg/g body weight) [2].
1. Bipiperidyl mustard produced increased adiposity in the rat without excessive weight gain or hyperphagia [3].

Psychiatry related information on Bipiperidyl mustard

Monosodium glutamate and bipiperidyl mustard both produce mediobasal hypothalamic lesions and have been reported to alter the subsequent feeding behavior and/or insulin levels of treated animals [4].

High impact information on Bipiperidyl mustard

Localization of goldthioglucose and bipiperidyl mustard lesions near artificial disruptions of the blood-brain barrier [1].
In order to determine if endogenous cholecystokinin played a role in the effects of glutamate or bipiperidyl mustard, concentrations of cholecystokinin in the pituitary glands of lesioned rats were measured [4].
Bipiperidyl mustard (BPM) primarily destroys VMH neurons, but has produced only a slight obesity even when rats were maintained on high-fat diets [5].
A single injection of N,N'-bis(beta-chloroethyl)-4,4'-bipiperidine (BPM) into 30-day old rats produced brain lesions in the ventromedial hypothalamus, the dorsal vagal complex (dorsal motor nucleus of the vagus and nucleus of the solitary tract), and the medial septum [6].
In a separate investigation, histological evidence of generalised hypothalmic lesions was observed in both chicks (Gallus domesticus) and ducklings (Anas platyrhynchos) injected with bipiperidyl mustard or gold thioglucose [2].

Chemical compound and disease context of Bipiperidyl mustard

Weanling mice were injected with gold thioglucose or bipiperidyl mustard which have been previously shown to cause obesity associated with ventromedial hypothalamic damage [7].

Anatomical context of Bipiperidyl mustard

Bi-weekly body weights, and eight week live, carcass, and abdominal fat plus carcass weights were depressed in chicks injected with bipiperidyl mustard, the depression being significant for eight-week abdominal fat weights [2].

Associations of Bipiperidyl mustard with other chemical compounds

Effect of bipiperidyl mustard and gold thioglucose on the hypothalamus and growth of the hatchling chick and duckling [2].

References

Localization of goldthioglucose and bipiperidyl mustard lesions near artificial disruptions of the blood-brain barrier. Levine, S., Sowinski, R. Exp. Neurol. (1983) [Pubmed]
Effect of bipiperidyl mustard and gold thioglucose on the hypothalamus and growth of the hatchling chick and duckling. Hopper, D.L., Satterlee, D.G. Br. Poult. Sci. (1984) [Pubmed]
The induction of obesity in the rat with bipiperidyl mustard. Jagot, S.A., Webb, G.P., Rogers, P.D., Dickerson, J.W. Br. J. Nutr. (1980) [Pubmed]
Hypothalamic neurotoxins alter the content of immunoreactive cholecystokinin in pituitary. Scallet, A.C., Faris, P.L., Beinfeld, M.C., Olney, J.W. Brain Res. (1987) [Pubmed]
Components of hypothalamic obesity: bipiperidyl-mustard lesions add hyperphagia to monosodium glutamate-induced hyperinsulinemia. Scallet, A.C., Olney, J.W. Brain Res. (1986) [Pubmed]
Bipiperidyl mustard produces brain lesions and obesity in the rat. Laughton, W., Powley, T.L. Brain Res. (1981) [Pubmed]
Adipocyte number and size in hypothalamic obesity induced in weanling mice by gold thioglucose and bipiperidyl mustard. Wise, A. Nutrition and metabolism. (1975) [Pubmed]

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