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MeSH Review

Abdominal Fat

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Disease relevance of Abdominal Fat


Psychiatry related information on Abdominal Fat

  • The present study was designed to measure interstitial levels of norepinephrine-regulating lipolysis (NE) in subcutaneous abdominal adipose tissue of anorexia nervosa (AN) patients and control subjects under basal conditions and after the local administration of an inhibitor of NE re-uptake, maprotiline [6].
  • This study demonstrates a significant relationship between internalized racism and abnormal levels of fasting glucose which may be mediated through abdominal fat [7].

High impact information on Abdominal Fat


Chemical compound and disease context of Abdominal Fat


Biological context of Abdominal Fat


Anatomical context of Abdominal Fat


Associations of Abdominal Fat with chemical compounds

  • Abdominal fat had a significantly stronger relationship with insulin sensitivity than peripheral nonabdominal fat (r2 = 0.79 vs. 0.44), and higher levels were associated with increased fasting nonesterified fatty acids, lipid oxidation, and hepatic glucose output [13].
  • In black women, high-density lipoprotein cholesterol was the only measurement adversely affected by abdominal fat; HDL cholesterol was significantly lower in the black UBO group (1.14 +/- 0.05 mM) compared with the black LBO group (1.37 +/- 0.08 mM) [28].
  • Both exercise training and food restriction significantly suppressed plasma levels of glucose and insulin and serum levels of triacylglycerol and cholesterol and reduced the accumulation of abdominal fat [29].
  • In all patients, the abdominal fat tissue, stained with Congo red, was negative for amyloid deposits [30].
  • BACKGROUND: Abdominal fat and circulating triacylglycerols increase with age, which indicates lipid overaccumulation [31].

Gene context of Abdominal Fat

  • The direct effect of PRL on the regulation of LPL activity in human abdominal adipose tissue cultured in vitro was investigated [32].
  • Waist to hip ratio did not correlate with the levels of circulating hormones or SHBG, but an inverse correlation was found between abdominal fat cell size and A as well as the LH to FSH ratio in the nonhirsute women of the obese group [16].
  • In addition, L-PRLR [relative molecular mass (M(r)) 90,000] and I-PRLR (M(r) 50,000) protein expression was detected in human sc abdominal adipose tissue and breast adipose tissue using immunoblot analysis [32].
  • We examined the association between the Ala(54)Thr variant in the FABP2 gene and levels of visceral (VAT) and sc (SAAT) abdominal fat in a group of 223 premenopausal African-American (n = 103) and Caucasian (n = 120) women [33].
  • Thirteen/fifteen orbital and abdominal fat samples from patients free of GD and TED, measured ex vivo, were negative for TSHR transcripts and two were at the limit of detection [34].

Analytical, diagnostic and therapeutic context of Abdominal Fat


  1. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. Lakka, H.M., Laaksonen, D.E., Lakka, T.A., Niskanen, L.K., Kumpusalo, E., Tuomilehto, J., Salonen, J.T. JAMA (2002) [Pubmed]
  2. Resistin, central obesity, and type 2 diabetes. McTernan, C.L., McTernan, P.G., Harte, A.L., Levick, P.L., Barnett, A.H., Kumar, S. Lancet (2002) [Pubmed]
  3. The clinical significance of amyloid fat deposits in rheumatoid arthritis: a systematic long-term followup study using abdominal fat aspiration. Gómez-Casanovas, E., Sanmartí, R., Solé, M., Cañete, J.D., Muñoz-Gómez, J. Arthritis Rheum. (2001) [Pubmed]
  4. Hyperinsulinemia and abdominal obesity affect the expression of hypertriglyceridemia in heterozygous familial lipoprotein lipase deficiency. Julien, P., Vohl, M.C., Gaudet, D., Gagné, C., Lévesque, G., Després, J.P., Cadelis, F., Brun, L.D., Nadeau, A., Ven Murthy, M.R. Diabetes (1997) [Pubmed]
  5. Short-term, high-fat diets lower circulating leptin concentrations in rats. Ainslie, D.A., Proietto, J., Fam, B.C., Thorburn, A.W. Am. J. Clin. Nutr. (2000) [Pubmed]
  6. Increased subcutaneous abdominal tissue norepinephrine levels in patients with anorexia nervosa: an in vivo microdialysis study. Nedvídková, J., Dostálová, I., Barták, V., Papezov, H., Pacák, K. Physiological research / Academia Scientiarum Bohemoslovaca. (2004) [Pubmed]
  7. Internalized racism, body fat distribution, and abnormal fasting glucose among African-Caribbean women in Dominica, West Indies. Butler, C., Tull, E.S., Chambers, E.C., Taylor, J. Journal of the National Medical Association. (2002) [Pubmed]
  8. Metformin in the treatment of HIV lipodystrophy syndrome: A randomized controlled trial. Hadigan, C., Corcoran, C., Basgoz, N., Davis, B., Sax, P., Grinspoon, S. JAMA (2000) [Pubmed]
  9. Demonstration of an in vivo functional beta 3-adrenoceptor in man. Enocksson, S., Shimizu, M., Lönnqvist, F., Nordenström, J., Arner, P. J. Clin. Invest. (1995) [Pubmed]
  10. Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue. Galitzky, J., Lafontan, M., Nordenström, J., Arner, P. J. Clin. Invest. (1993) [Pubmed]
  11. Influences of variation in total energy intake and dietary composition on regulation of fat cell lipolysis in ideal-weight subjects. Kather, H., Wieland, E., Scheurer, A., Vogel, G., Wildenberg, U., Joost, C. J. Clin. Invest. (1987) [Pubmed]
  12. Visceral abdominal-fat accumulation associated with use of indinavir. Miller, K.D., Jones, E., Yanovski, J.A., Shankar, R., Feuerstein, I., Falloon, J. Lancet (1998) [Pubmed]
  13. Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Carey, D.G., Jenkins, A.B., Campbell, L.V., Freund, J., Chisholm, D.J. Diabetes (1996) [Pubmed]
  14. The transient hypercholesterolemia of major weight loss. Phinney, S.D., Tang, A.B., Waggoner, C.R., Tezanos-Pinto, R.G., Davis, P.A. Am. J. Clin. Nutr. (1991) [Pubmed]
  15. Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of metformin at the start and after more than one year of therapy. Ibáñez, L., de Zegher, F. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  16. Sex steroid, gonadotropin, cortisol, and prolactin levels in healthy, massively obese women: correlation with abdominal fat cell size and effect of weight reduction. Grenman, S., Rönnemaa, T., Irjala, K., Kaihola, H.L., Grönroos, M. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  17. Effects of clenbuterol on insulin resistance in conscious obese Zucker rats. Pan, S.J., Hancock, J., Ding, Z., Fogt, D., Lee, M., Ivy, J.L. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  18. Serum lipids, glucose homeostasis and abdominal adipose tissue distribution in protease inhibitor-treated and naive HIV-infected children. Bitnun, A., Sochett, E., Babyn, P., Holowka, S., Stephens, D., Read, S., King, S.M. AIDS (2003) [Pubmed]
  19. A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol. Rosmond, R., Chagnon, M., Bouchard, C., Björntorp, P. Diabetologia (2001) [Pubmed]
  20. Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. Johannsson, G., Mårin, P., Lönn, L., Ottosson, M., Stenlöf, K., Björntorp, P., Sjöström, L., Bengtsson, B.A. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  21. Anovulation in eumenorrheic, nonobese adolescent girls born small for gestational age: insulin sensitization induces ovulation, increases lean body mass, and reduces abdominal fat excess, dyslipidemia, and subclinical hyperandrogenism. Ibáñez, L., Potau, N., Ferrer, A., Rodriguez-Hierro, F., Marcos, M.V., De Zegher, F. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  22. Abdominal fat determines growth hormone-binding protein levels in healthy nonobese adults. Fisker, S., Vahl, N., Jørgensen, J.O., Christiansen, J.S., Orskov, H. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  23. Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Després, J.P., Nadeau, A., Tremblay, A., Ferland, M., Moorjani, S., Lupien, P.J., Thériault, G., Pinault, S., Bouchard, C. Diabetes (1989) [Pubmed]
  24. The vitamin D-binding protein, alpha-fetoprotein, albumin multigene family: detection of transcripts in multiple tissues. McLeod, J.F., Cooke, N.E. J. Biol. Chem. (1989) [Pubmed]
  25. Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial. Franco, C., Brandberg, J., Lönn, L., Andersson, B., Bengtsson, B.A., Johannsson, G. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  26. Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women. Rendell, M., Hulthén, U.L., Törnquist, C., Groop, L., Mattiasson, I. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  27. Distribution of RU 486 and its demethylated metabolites in humans. Heikinheimo, O., Haukkamaa, M., Lähteenmäki, P. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  28. Race-dependent health risks of upper body obesity. Dowling, H.J., Pi-Sunyer, F.X. Diabetes (1993) [Pubmed]
  29. Effect of exercise training and food restriction on endothelium-dependent relaxation in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous NIDDM. Sakamoto, S., Minami, K., Niwa, Y., Ohnaka, M., Nakaya, Y., Mizuno, A., Kuwajima, M., Shima, K. Diabetes (1998) [Pubmed]
  30. Lack of amyloid in abdominal fat aspirates from patients undergoing long-term hemodialysis. Varga, J., Idelson, B.A., Felson, D., Skinner, M., Cohen, A.S. Arch. Intern. Med. (1987) [Pubmed]
  31. Metabolic risks identified by the combination of enlarged waist and elevated triacylglycerol concentration. Kahn, H.S., Valdez, R. Am. J. Clin. Nutr. (2003) [Pubmed]
  32. Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue. Ling, C., Svensson, L., Odén, B., Weijdegård, B., Edén, B., Edén, S., Billig, H. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  33. Association of the intestinal fatty acid-binding protein Ala54Thr polymorphism and abdominal adipose tissue in African-American and Caucasian women. Lara-Castro, C., Hunter, G.R., Lovejoy, J.C., Gower, B.A., Fernández, J.R. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  34. Adipose thyrotrophin receptor expression is elevated in Graves' and thyroid eye diseases ex vivo and indicates adipogenesis in progress in vivo. Starkey, K.J., Janezic, A., Jones, G., Jordan, N., Baker, G., Ludgate, M. J. Mol. Endocrinol. (2003) [Pubmed]
  35. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Short, K.R., Vittone, J.L., Bigelow, M.L., Proctor, D.N., Rizza, R.A., Coenen-Schimke, J.M., Nair, K.S. Diabetes (2003) [Pubmed]
  36. Whole-body and adipose tissue glucose metabolism in response to short-term fasting in lean and obese women. Horowitz, J.F., Coppack, S.W., Klein, S. Am. J. Clin. Nutr. (2001) [Pubmed]
  37. Endurance training and GH administration in elderly women: effects on abdominal adipose tissue lipolysis. Lange, K.H., Lorentsen, J., Isaksson, F., Juul, A., Rasmussen, M.H., Christensen, N.J., Bülow, J., Kjaer, M. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
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