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Chemical Compound Review

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Disease relevance of glutamate


Psychiatry related information on glutamate


High impact information on glutamate

  • Pulsatile, but not continuous GHRF also stimulates growth in animals made GHRF-deficient by neonatal monosodium glutamate treatment [11].
  • These results show that the arcuate nucleus is the origin of the GRF-containing fibres that project to the median eminence and establish the MSG-treated rat as an in vivo model for studying growth hormone secretion in the absence of neurohumoral GRF [12].
  • Specific depletion of immunoreactive growth hormone-releasing factor by monosodium glutamate in rat median eminence [12].
  • MSG treatment results in the complete loss of GRF-immunoreactive cell bodies within this nucleus and provokes a selective disappearance of GRF-immunoreactive fibres in the median eminence [12].
  • Decreased (58 to 80 percent) complement factor D activity, relative to lean controls, was observed as a common feature of several experimental models of obesity, including the ob/ob, db/db, and monosodium glutamate (MSG)-injected mouse and the fa/fa rat [13].

Chemical compound and disease context of glutamate


Biological context of glutamate

  • Females treated with MSG had fewer pregnancies and smaller litters, while males treated with MSG showed reduced fertility [3].
  • Subchronic multiple dosing of NN2211 (200 microg/kg) twice daily for 10 days to normal and MSG-treated rats caused profound inhibition of food intake [19].
  • A single bolus injection of NN2211 caused profound dose-dependent inhibition of overnight food and water intake and increased diuresis in both normal and MSG-treated rats [19].
  • However, only those mice with 938 bp of the adipsin upstream regulatory region showed suppression of expression in adipose tissue in mice that were induced to become obese with monosodium glutamate [20].
  • In order to investigate the asthma-provoking potential of the widely used flavor enhancer, monosodium L-glutamate (MSG), we challenged 32 subjects with asthma, a number of whom gave histories of severe asthma after Chinese restaurant meals or similarly spiced meals [21].

Anatomical context of glutamate


Associations of glutamate with other chemical compounds


Gene context of glutamate


Analytical, diagnostic and therapeutic context of glutamate

  • In the ob/ob, UCP-DTA and MSG models, overexpression of ob mRNA is reversed by caloric restriction [36].
  • Using a novel long-acting injectable GLP-1 derivative, NN2211, the acute and subchronic anorectic potentials of GLP-1 and derivatives were studied in both normal rats and rats made obese by neonatal monosodium glutamate treatment (MSG) [19].
  • In the present study, the effects of intermittent GH treatment on liver CYP expression were studied in adult rats rendered GH deficient by neonatal administration of monosodium glutamate (MSG), which depletes circulating adult GH without the global loss of other pituitary-dependent hormones that is associated with hypophysectomy [37].
  • OBJECTIVE: We conducted a multicenter, multiphase, double-blind, placebo-controlled study with a crossover design to evaluate reactions reportedly caused by MSG [38].
  • We also observed that the preference for the monosodium glutamate solution was not induced in animals fed a low-protein diet [39].


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