The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Thioglucose     (2R,3S,4S,5R,6S)-2- (hydroxymethyl)-6...

Synonyms: beta-D-Glc-SH, beta-D-Glcp-SH, CHEMBL132376, CPD-3742, AG-H-00245, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of glucose


High impact information on glucose


Chemical compound and disease context of glucose


Biological context of glucose

  • We propose that the thioglucose-alpha' chain bond was formed during the course of C activation by a reaction between the "labile binding site" of newly released C3b and the (then) particle-bound sugar [15].
  • The injection of gold thioglucose led to increased food intake in both PBB/Ld and C57B1/6J mice [16].
  • The present studies have examined the diurnal rhythm of corticosterone in genetically obese mice and in mice made obese by treatment with gold thioglucose [17].
  • Extrahepatic fatty acid synthesis from a 250 mg meal of [U-(14)C]-glucose was measured in epidymal fat pads and the remaining carcass of hyperglycemic obese (obob), gold thioglucose obese, and nonobese controls under conditions of maximum and minimum lipogenesis [18].
  • Effect of gold thioglucose-induced obesity on adipose tissue weight and cellularity in male and female mice suckled in large and small litters: investigations into sex differences and site differences [19].

Anatomical context of glucose


Associations of glucose with other chemical compounds


Gene context of glucose


Analytical, diagnostic and therapeutic context of glucose


  1. Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. Röhl, M., Pasparakis, M., Baudler, S., Baumgartl, J., Gautam, D., Huth, M., De Lorenzi, R., Krone, W., Rajewsky, K., Brüning, J.C. J. Clin. Invest. (2004) [Pubmed]
  2. Insulin response to an intravenous glucose load during development of obesity in gold thioglucose-injected mice. Blair, S.C., Caterson, I.D., Cooney, G.J. Diabetes (1993) [Pubmed]
  3. Gold thioglucose-induced hypothalamic damage, hyperphagia, and obesity: dependence on the adrenal gland. Debons, A.F., Siclari, E., Das, K.C., Fuhr, B. Endocrinology (1982) [Pubmed]
  4. Intraventricular corticosterone increases the rate of body weight gain in underweight adrenalectomized rats. Green, P.K., Wilkinson, C.W., Woods, S.C. Endocrinology (1992) [Pubmed]
  5. Ventral medial hypothalamus: involvement in hypoglycemic convulsions. Kellar, K.J., Langley, A.E., Marks, B.H., O'Neill, J.J. Science (1975) [Pubmed]
  6. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. Vidal-Puig, A., Jimenez-Liñan, M., Lowell, B.B., Hamann, A., Hu, E., Spiegelman, B., Flier, J.S., Moller, D.E. J. Clin. Invest. (1996) [Pubmed]
  7. Absence of microtubule sliding and an analysis of spindle formation and elongation in isolated mitotic spindles from the yeast Saccharomyces cerevisiae. King, S.M., Hyams, J.S., Luba, A. J. Cell Biol. (1982) [Pubmed]
  8. p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Chen, D., Mauvais-Jarvis, F., Bluher, M., Fisher, S.J., Jozsi, A., Goodyear, L.J., Ueki, K., Kahn, C.R. Mol. Cell. Biol. (2004) [Pubmed]
  9. Effect of IGF-I on phosphatidylinositol 3-kinase in soleus muscle of lean and insulin-resistant obese mice. Jullien, D., Heydrick, S.J., Gautier, N., Van Obberghen, E., Le Marchand-Brustel, Y. Diabetes (1996) [Pubmed]
  10. The effect of body weight and the fatty acid-oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in mouse heart. Caterson, I.D., Williams, P.F., Kerbey, A.L., Astbury, L.D., Plehwe, W.E., Turtle, J.R. Biochem. J. (1984) [Pubmed]
  11. Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells. Traber, K.E., Okamoto, H., Kurono, C., Baba, M., Saliou, C., Soji, T., Packer, L., Okamoto, T. Int. Immunol. (1999) [Pubmed]
  12. Effects of ovariectomy and estradiol on body weight and food intake in gold thioglucose-treated mice. Blaustein, J.D., Gentry, R.T., Roy, E.J., Wade, G.N. Physiol. Behav. (1976) [Pubmed]
  13. Effects of a new anorectic drug (PM 170) on development of gold thioglucose-induced obesity in mice. Massicot, F., Falcou, R., Heymans, F., Godfroid, J.J., Apfelbaum, M. Gen. Pharmacol. (1987) [Pubmed]
  14. Adipocyte number and size in hypothalamic obesity induced in weanling mice by gold thioglucose and bipiperidyl mustard. Wise, A. Nutrition and metabolism. (1975) [Pubmed]
  15. The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway. Mann, J., O'Brien, R., Hostetter, M.K., Alper, C.A., Rosen, F.S., Babior, B.M. J. Immunol. (1981) [Pubmed]
  16. Description of obesity in the PBB/Ld mouse. Walkley, S.U., Hunt, C.E., Clements, R.S., Lindsey, J.R. J. Lipid Res. (1978) [Pubmed]
  17. Diurnal rhythm for corticosterone in obese (ob/ob) diabetes (db/db) and gold-thioglucose-induced obesity in mice. Saito, M., Bray, G.A. Endocrinology (1983) [Pubmed]
  18. A comparison of extrahepatic lipogenesis from a small glucose meal in obob and gold thioglucose obese mice fed low- or high-fat diets with or without the addition of Delta22-5beta-taurocholenic acid. Jansen, G.R. J. Nutr. Biochem. (2000) [Pubmed]
  19. Effect of gold thioglucose-induced obesity on adipose tissue weight and cellularity in male and female mice suckled in large and small litters: investigations into sex differences and site differences. Enser, M., Roberts, J., Whittington, F. Br. J. Nutr. (1985) [Pubmed]
  20. Islet cell function in gold thioglucose-induced obesity in mice. Caterson, I.D., Taylor, K.W. Diabetologia (1982) [Pubmed]
  21. Gold thioglucose, mimpa and lesions of the ventromedial hypothalamus. Brown, D.F. J. Neuropathol. Exp. Neurol. (1984) [Pubmed]
  22. Distribution of various labeled thioglucoses in rodents. Atkins, H.L., Lambrecht, R.M., Wolf, A.P., Ansari, A.N., Guillaume, M. Radiology. (1975) [Pubmed]
  23. Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate. Teronen, O., Konttinen, Y.T., Lindqvist, C., Salo, T., Ingman, T., Lauhio, A., Ding, Y., Santavirta, S., Sorsa, T. J. Dent. Res. (1997) [Pubmed]
  24. Decreased resistin expression in mice with different sensitivities to a high-fat diet. Le Lay, S., Boucher, J., Rey, A., Castan-Laurell, I., Krief, S., Ferré, P., Valet, P., Dugail, I. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  25. Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. Mandel, S.J., Berry, M.J., Kieffer, J.D., Harney, J.W., Warne, R.L., Larsen, P.R. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  26. Pyruvate dehydrogenase-complex activity in brown adipose tissue of gold thioglucose-obese mice. Cooney, G.J., Denyer, G.S., Kerbey, A.L., Frankland, R.L., Blair, S.C., Williams, P.F., Caterson, I.D. Biochem. J. (1990) [Pubmed]
  27. Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil. Kuiper, G.G., Klootwijk, W., Morvan Dubois, G., Destree, O., Darras, V.M., Van der Geyten, S., Demeneix, B., Visser, T.J. Endocrinology (2006) [Pubmed]
  28. Studies on the effect of D-penicillamine, gold thioglucose and methotrexate on streptococcal cell wall arthritis. Ridge, S.C., Rath, N., Galivan, J., Zabriske, J., Oronsky, A.L., Kerwar, S.S. J. Rheumatol. (1986) [Pubmed]
  29. Scrg1 is induced in TSE and brain injuries, and associated with autophagy. Dron, M., Bailly, Y., Beringue, V., Haeberlé, A.M., Griffond, B., Risold, P.Y., Tovey, M.G., Laude, H., Dandoy-Dron, F. Eur. J. Neurosci. (2005) [Pubmed]
  30. VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. Hahm, S., Fekete, C., Mizuno, T.M., Windsor, J., Yan, H., Boozer, C.N., Lee, C., Elmquist, J.K., Lechan, R.M., Mobbs, C.V., Salton, S.R. J. Neurosci. (2002) [Pubmed]
  31. PTP1B regulates leptin signal transduction in vivo. Zabolotny, J.M., Bence-Hanulec, K.K., Stricker-Krongrad, A., Haj, F., Wang, Y., Minokoshi, Y., Kim, Y.B., Elmquist, J.K., Tartaglia, L.A., Kahn, B.B., Neel, B.G. Dev. Cell (2002) [Pubmed]
  32. Characterization and localization of mouse hypothalamic growth hormone-releasing factor and effect of gold thioglucose-induced hypothalamic lesions. Miki, N., Ono, M., Asakawa-Yasumoto, K., Aoki, T., Murata, Y., Ishituka, Y., Demura, H., Sasaki, F. J. Neuroendocrinol. (1994) [Pubmed]
  33. Effect of delta22-5beta-taurocholenic acid on hepatic cholesterol and fatty acid in gold thioglucose obese mice fed low- or high-fat diets. Jansen, G.R. J. Nutr. Biochem. (1999) [Pubmed]
  34. A novel, enzymatically active conformation of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I). Böttcher, B., Scheide, D., Hesterberg, M., Nagel-Steger, L., Friedrich, T. J. Biol. Chem. (2002) [Pubmed]
  35. Anorexia after adrenalectomy in gold thioglucose-treated obese mice. Debons, A.F., Das, K.C., Fuhr, B., Siclari, E. Endocrinology (1983) [Pubmed]
  36. Acid dissociation and metal complex formation constants of penicillamine, cysteine, and antiarthritic gold complexes at simulated biological conditions. Zucconi, T.D., Janauer, G.E., Donahe, S., Lewkowicz, C. Journal of pharmaceutical sciences. (1979) [Pubmed]
  37. The influence of direct implantation of gold thioglucose into the brain of chickens on food consumption and weight gain. Smith, C.J., Szper, I. Poult. Sci. (1976) [Pubmed]
WikiGenes - Universities