The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Aureotan     gold(+1) cation; 3,4,5-trihydroxy-6...

Synonyms: Aurumine, Auromyose, Aurotan, Authron, Romosol, ...
This record was replaced with 175998.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol


High impact information on 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol

  • The level of Ob-Rb in hypothalamus is reduced in mice rendered obese by gold thioglucose (GTG), which causes hypothalamic lesions [6].
  • The obesity in GTG-treated mice is likely to be caused by ablation of Ob-Rb-expressing neurons, which results in leptin resistance [6].
  • Insulin and insulin-like growth factor I. Effects on protein synthesis in isolated muscles from lean and goldthioglucose-obese mice [7].
  • Liver, aorta, and skeletal muscle of ob/ob mice, and mice made obese and hyperinsulinaemic by injection of gold-thioglucose contained greater amounts of farnesylated p21Ras than tissues of their lean normoinsulinaemic counterparts [8].
  • The pancreatic content of somatostatin, insulin, and glucagon and the hypothalamic content of somatostatin were examined in ob/ob mice at various ages and in goldthioglucose-obese mice [9].

Chemical compound and disease context of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol


Biological context of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol

  • These early and diverse changes in PDHa argue for a multifactorial aetiology in the development of the whole-body insulin resistance seen in older gold-thioglucose-treated obese animals [15].
  • Examples of the latter include a) augmentation of goldthioglucose neurotoxicity, b) induction of hypothalamic anovulation and reproductive failure, c) exacerbation of porphyric encephalopathy, and d) potentiation of parkinsonism and other free radical-related neurodegenerations [16].
  • Instead, it is more likely that reduced blood glucose levels after ADX of GTG-obese mice are the result of decreased gluconeogenesis in the liver [17].
  • In order to determine the effect of inflammation on brain glycolysis in the absence of leukocyte infiltration, [14C]deoxyglucose autoradiography and hematoxylin-eosin (HE) counter-staining were applied to mice at various times after the induction of chemotoxic inflammatory brain lesions by the systemic administration of goldthioglucose [18].
  • All mammalian thioredoxin reductase isozymes are homologous to glutathione reductase and contain a conserved C-terminal elongation with a cysteine-selenocysteine sequence forming a redox-active selenenylsulfide/selenolthiol active site and are inhibited by goldthioglucose (aurothioglucose) and other clinically used drugs [19].

Anatomical context of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol


Associations of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol with other chemical compounds


Gene context of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol


Analytical, diagnostic and therapeutic context of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol


  1. Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Ishii, M., Fei, H., Friedman, J.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Effect of work-induced hypertrophy on muscle glucose metabolism in lean and obese mice. Augert, G., Van de Werve, G., Le Marchand-Brustel, Y. Diabetologia (1985) [Pubmed]
  3. Neural pathways involved in the hypothalamic integration of autonomic responses. Powley, T.L., Laughton, W. Diabetologia (1981) [Pubmed]
  4. Metabolic regulation as a control for lipid disorders. I. Influence of (--)-hydroxycitrate on experimentally induced obesity in the rodent. Sullivan, C., Triscari, J. Am. J. Clin. Nutr. (1977) [Pubmed]
  5. Thermogenic and antiobesity activity of a novel beta-adrenoceptor agonist (BRL 26830A) in mice and rats. Arch, J.R., Ainsworth, A.T. Am. J. Clin. Nutr. (1983) [Pubmed]
  6. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Fei, H., Okano, H.J., Li, C., Lee, G.H., Zhao, C., Darnell, R., Friedman, J.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Insulin and insulin-like growth factor I. Effects on protein synthesis in isolated muscles from lean and goldthioglucose-obese mice. Monier, S., Le Cam, A., Le Marchand-Brustel, Y. Diabetes (1983) [Pubmed]
  8. Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals. Goalstone, M.L., Wall, K., Leitner, J.W., Kurowski, T., Ruderman, N., Pan, S.J., Ivy, J.L., Moller, D.E., Draznin, B. Diabetologia (1999) [Pubmed]
  9. Somatostatin in the pancreas and hypothalamus of obese mice. Dolais-Kitabgi, J., Le Marchand-Brustel, Y., Freychet, P. Diabetologia (1979) [Pubmed]
  10. Tissue differences in the response of the pyruvate dehydrogenase complex to a glucose load during the development of obesity in gold-thioglucose-obese mice. Bryson, J.M., Cooney, G.J., Wensley, V.R., Phuyal, J.L., Caterson, I.D. Biochem. J. (1995) [Pubmed]
  11. Control of prolactin and growth hormone secretion in mice by obesity. Sinha, Y.N., Salocks, C.B., Vanderlaan, W.P. Endocrinology (1976) [Pubmed]
  12. Central nervous system control of hyperphagia in hypothalamic obesity: dependence on adrenal glucocorticoids. Debons, A.F., Zurek, L.D., Tse, C.S., Abrahamsen, S. Endocrinology (1986) [Pubmed]
  13. Vitamin E status in gold-thioglucose-treated obese mice: the influence of weight loss. Vandewoude, M.G., Van Gaal, L., Dalemans, C., De Leeuw, I. International journal of obesity. (1985) [Pubmed]
  14. Association of altered brain norephinephrine and serotonin with the obesity induced by goldthioglucose in mice. Coscina, D.V., McArthur, R.A., Stancer, H.C., Godse, D.D. Pharmacol. Biochem. Behav. (1978) [Pubmed]
  15. The activity of the pyruvate dehydrogenase complex in heart and liver from mice during the development of obesity and insulin resistance. Caterson, I.D., Astbury, L.D., Williams, P.F., Vanner, M.A., Cooney, G.J., Turtle, J.R. Biochem. J. (1987) [Pubmed]
  16. Gomori-positive astrocytes: biological properties and implications for neurologic and neuroendocrine disorders. Schipper, H.M. Glia (1991) [Pubmed]
  17. Hepatic gluconeogenesis and the activity of PDH in individual tissues of GTG-obese mice following adrenalectomy. Blair, S.C., Greenaway, T.M., Bryson, J.M., Phuyal, J.L., Wensley, V.R., Caterson, I.D., Cooney, G.J. Obes. Res. (1996) [Pubmed]
  18. Glycolytic concomitant of brain inflammation produced by goldthioglucose. Dirocco, R.J., Coons, E.E. Brain Res. (1985) [Pubmed]
  19. Physiological functions of thioredoxin and thioredoxin reductase. Arnér, E.S., Holmgren, A. Eur. J. Biochem. (2000) [Pubmed]
  20. The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity. Tartare-Deckert, S., Chavey, C., Monthouel, M.N., Gautier, N., Van Obberghen, E. J. Biol. Chem. (2001) [Pubmed]
  21. Ultrastructure of hypothalamic and medullary lesions caused by an aliphatic triamine. Nochlin, D., Levine, S. J. Neuropathol. Exp. Neurol. (1982) [Pubmed]
  22. Inactivation of pyruvate dehydrogenase complex in heart muscle mitochondria of gold-thioglucose-induced obese mice is not due to a stable increase in activity of pyruvate dehydrogenase kinase. Caterson, I.D., Kerbey, A.L., Cooney, G.J., Frankland, R., Denyer, G.S., Nicks, J., Williams, P.F. Biochem. J. (1988) [Pubmed]
  23. Prolactin and growth hormone secretion in chemically induced and genetically obese mice. Sinha, Y.N., Salocks, C.B., Vanderlaan, W.P. Endocrinology (1975) [Pubmed]
  24. Food restriction normalizes chylomicron remnant metabolism in murine models of obesity as assessed by a novel stable isotope breath test. Martins, I.J., Tran, J.M., Redgrave, T.G. J. Nutr. (2002) [Pubmed]
  25. Increased gluconeogenesis in hepatocytes from GTG-obese mice is insensitive to inhibition by insulin. Greenaway, T.M., Cooney, G.J., Blair, S.C., Caterson, I.D. Int. J. Obes. Relat. Metab. Disord. (1992) [Pubmed]
  26. Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin. Bergen, H.T., Mizuno, T.M., Taylor, J., Mobbs, C.V. Endocrinology (1998) [Pubmed]
  27. Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes. Shirakami, A., Toyonaga, T., Tsuruzoe, K., Shirotani, T., Matsumoto, K., Yoshizato, K., Kawashima, J., Hirashima, Y., Miyamura, N., Kahn, C.R., Araki, E. J. Endocrinol. (2002) [Pubmed]
  28. Adiponectin Expression is Paradoxically Increased in Gold-thioglucose-induced Obesity. Huypens, P., Quartier, E. Horm. Metab. Res. (2006) [Pubmed]
  29. Peroxisomal beta-oxidation in liver and muscles of gold-thioglucose-induced obese mice: correlation with body weight. Asayama, K., Okada, Y., Kato, K. International journal of obesity. (1991) [Pubmed]
  30. Paradoxical reduction of atherosclerosis in apoE-deficient mice with obesity-related type 2 diabetes. Lyngdorf, L.G., Gregersen, S., Daugherty, A., Falk, E. Cardiovasc. Res. (2003) [Pubmed]
  31. Cocaine and amphetamine-regulated transcript mRNA regulation in the hypothalamus in lean and obese rodents. Robson, A.J., Rousseau, K., Loudon, A.S., Ebling, F.J. J. Neuroendocrinol. (2002) [Pubmed]
  32. The effects of dietary n - 3 fatty acid in animal models of type 1 and type 2 diabetes. Sullivan, D.R., Yue, D.K., Capogreco, C., McLennan, S., Nicks, J., Cooney, G., Caterson, I., Turtle, J.R., Hensley, W.J. Diabetes Res. Clin. Pract. (1990) [Pubmed]
  33. Exploring the expression of the melanin-concentrating hormone messenger RNA in the rat lateral hypothalamus after goldthioglucose injection. Grillon, S., Hervé, C., Griffond, B., Fellmann, D. Neuropeptides (1997) [Pubmed]
  34. Effect of electrolytic and chemical ventromedial hypothalamic lesions on food intake, body weight, analgesia and the CNS opioid peptides in rats and mice. Tejwani, G.A., Richard, C.W. NIDA Res. Monogr. (1986) [Pubmed]
WikiGenes - Universities