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Chemical Compound Review

Aureotan     gold(+1) cation; 3,4,5-trihydroxy-6...

Synonyms: Aurumine, Auromyose, Aurotan, Authron, Romosol, ...
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Disease relevance of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol

 

High impact information on 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol

  • The level of Ob-Rb in hypothalamus is reduced in mice rendered obese by gold thioglucose (GTG), which causes hypothalamic lesions [6].
  • The obesity in GTG-treated mice is likely to be caused by ablation of Ob-Rb-expressing neurons, which results in leptin resistance [6].
  • Insulin and insulin-like growth factor I. Effects on protein synthesis in isolated muscles from lean and goldthioglucose-obese mice [7].
  • Liver, aorta, and skeletal muscle of ob/ob mice, and mice made obese and hyperinsulinaemic by injection of gold-thioglucose contained greater amounts of farnesylated p21Ras than tissues of their lean normoinsulinaemic counterparts [8].
  • The pancreatic content of somatostatin, insulin, and glucagon and the hypothalamic content of somatostatin were examined in ob/ob mice at various ages and in goldthioglucose-obese mice [9].
 

Chemical compound and disease context of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol

 

Biological context of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol

  • These early and diverse changes in PDHa argue for a multifactorial aetiology in the development of the whole-body insulin resistance seen in older gold-thioglucose-treated obese animals [15].
  • Examples of the latter include a) augmentation of goldthioglucose neurotoxicity, b) induction of hypothalamic anovulation and reproductive failure, c) exacerbation of porphyric encephalopathy, and d) potentiation of parkinsonism and other free radical-related neurodegenerations [16].
  • Instead, it is more likely that reduced blood glucose levels after ADX of GTG-obese mice are the result of decreased gluconeogenesis in the liver [17].
  • In order to determine the effect of inflammation on brain glycolysis in the absence of leukocyte infiltration, [14C]deoxyglucose autoradiography and hematoxylin-eosin (HE) counter-staining were applied to mice at various times after the induction of chemotoxic inflammatory brain lesions by the systemic administration of goldthioglucose [18].
  • All mammalian thioredoxin reductase isozymes are homologous to glutathione reductase and contain a conserved C-terminal elongation with a cysteine-selenocysteine sequence forming a redox-active selenenylsulfide/selenolthiol active site and are inhibited by goldthioglucose (aurothioglucose) and other clinically used drugs [19].
 

Anatomical context of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol

 

Associations of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol with other chemical compounds

 

Gene context of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol

 

Analytical, diagnostic and therapeutic context of 2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol

References

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