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Chemical Compound Review:

PCB 4 1-chloro-2-(2- chlorophenyl)benzene

Synonyms: CHEMBL417802, SureCN671133, AG-D-61410, NSC-59902, NSC59902, ...

Chung, D. et al., Chung, D. et al., Yang, J.H. et al., Kodavanti, P.R. et al., Sietmann, R. et al., et al.

Sietmann, Gesell, Hammer, Schauer,

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High impact information on 2,2'-Dichlorbiphenyl [German]

2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions [1].
Previously, we reported that 2,2'-dichlorobiphenyl (2,2'-DCB)-induced decreases of amplitude and synchronization of uterine contractions are dependent on MAPK-induced phosphorylation of Connexin43 (Cx43) and inhibition of myometrial gap junctions [2].
Potential role for oxidative stress in 2,2'-dichlorobiphenyl-induced inhibition of uterine contractions but not myometrial gap junctions [2].
Cells were exposed to 2,2'-dichlorobiphenyl (ortho PCB; 2,2'-DCB) or 4,4'-dichlorobiphenyl (non-ortho PCB; 4,4'-DCB) for 15 min, respectively, and subsequently fractionated and immunoblotted against the selected PKC monoclonal antibodies (alpha, gamma, delta, epsilon, lambda, iota) [3].
We compared the effects of two PCB congeners on Ca2+ homeostasis in cerebellar granule cells: 2,2'-dichlorobiphenyl (DCBP), a putative neurotoxic congener, and 3,3',4,4',5-pentachlorobiphenyl (PCBP), a presumed nonneurotoxic congener [4].

Biological context of 2,2'-Dichlorbiphenyl [German]

Effect of 2,2'-dichlorobiphenyl (PCB) on the embryonic development of the NMRI mouse [5].

Anatomical context of 2,2'-Dichlorbiphenyl [German]

The present study examined the hypothesis that inhibition of myometrial gap junctions through MAPK1-induced phosphorylation of GJA1 (connexin43) leads to inhibition of spontaneous phasic uterine contractions by 2,2'-dichlorobiphenyl (2,2'-DCB) [1].
The usefulness of isolated liver cells for the study of hepatocellular transport and metabolism is demonstrated, using 1-naphthol and 2,2'-dichlorobiphenyl as model compounds [6].

Associations of 2,2'-Dichlorbiphenyl [German] with other chemical compounds

Twofold chlorinated biphenyl derivatives did not serve as substrates for oxidation by either organism with the exception of 2,2'-dichlorobiphenyl, transformed by the yeast Trichosporon mucoides to two monohydroxylated derivatives [7].

Gene context of 2,2'-Dichlorbiphenyl [German]

Pond snails (Lymnaea stagnalis (L.)) were treated with 2,2'-dichlorobiphenyl (DCB) or 4,4'-DCB, to examine the toxicokinetic profile of these compounds [8].

References

2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions. Chung, D., Loch Caruso, R. Biol. Reprod. (2005) [Pubmed]
Potential role for oxidative stress in 2,2'-dichlorobiphenyl-induced inhibition of uterine contractions but not myometrial gap junctions. Chung, D., Caruso, R.L. Toxicol. Sci. (2006) [Pubmed]
Possible molecular targets of halogenated aromatic hydrocarbons in neuronal cells. Yang, J.H., Kodavanti, P.R. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
Comparative effects of two polychlorinated biphenyl congeners on calcium homeostasis in rat cerebellar granule cells. Kodavanti, P.R., Shin, D.S., Tilson, H.A., Harry, G.J. Toxicol. Appl. Pharmacol. (1993) [Pubmed]
Effect of 2,2'-dichlorobiphenyl (PCB) on the embryonic development of the NMRI mouse. Török, P. Environmental quality and safety. Supplement. (1975) [Pubmed]
An experimental model for the study of hepatic transport and metabolism of toxic compounds. Schwenk, M., López del Pino, V., Remmer, H. Arch. Toxicol. Suppl. (1979) [Pubmed]
Oxidative ring cleavage of low chlorinated biphenyl derivatives by fungi leads to the formation of chlorinated lactone derivatives. Sietmann, R., Gesell, M., Hammer, E., Schauer, F. Chemosphere (2006) [Pubmed]
Comparative toxicokinetics of 2,2'- and 4,4'-dichlorobiphenyls in the pond snail Lymnaea stagnalis (L.). Wilbrink, M., Treskes, M., De Vlieger, T.A., Vermeulen, N.P. Arch. Environ. Contam. Toxicol. (1990) [Pubmed]

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