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Chemical Compound Review

PCB 4     1-chloro-2-(2- chlorophenyl)benzene

Synonyms: CHEMBL417802, SureCN671133, AG-D-61410, NSC-59902, NSC59902, ...
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High impact information on 2,2'-Dichlorbiphenyl [German]


Biological context of 2,2'-Dichlorbiphenyl [German]


Anatomical context of 2,2'-Dichlorbiphenyl [German]


Associations of 2,2'-Dichlorbiphenyl [German] with other chemical compounds

  • Twofold chlorinated biphenyl derivatives did not serve as substrates for oxidation by either organism with the exception of 2,2'-dichlorobiphenyl, transformed by the yeast Trichosporon mucoides to two monohydroxylated derivatives [7].

Gene context of 2,2'-Dichlorbiphenyl [German]

  • Pond snails (Lymnaea stagnalis (L.)) were treated with 2,2'-dichlorobiphenyl (DCB) or 4,4'-DCB, to examine the toxicokinetic profile of these compounds [8].


  1. 2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions. Chung, D., Loch Caruso, R. Biol. Reprod. (2005) [Pubmed]
  2. Potential role for oxidative stress in 2,2'-dichlorobiphenyl-induced inhibition of uterine contractions but not myometrial gap junctions. Chung, D., Caruso, R.L. Toxicol. Sci. (2006) [Pubmed]
  3. Possible molecular targets of halogenated aromatic hydrocarbons in neuronal cells. Yang, J.H., Kodavanti, P.R. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  4. Comparative effects of two polychlorinated biphenyl congeners on calcium homeostasis in rat cerebellar granule cells. Kodavanti, P.R., Shin, D.S., Tilson, H.A., Harry, G.J. Toxicol. Appl. Pharmacol. (1993) [Pubmed]
  5. Effect of 2,2'-dichlorobiphenyl (PCB) on the embryonic development of the NMRI mouse. Török, P. Environmental quality and safety. Supplement. (1975) [Pubmed]
  6. An experimental model for the study of hepatic transport and metabolism of toxic compounds. Schwenk, M., López del Pino, V., Remmer, H. Arch. Toxicol. Suppl. (1979) [Pubmed]
  7. Oxidative ring cleavage of low chlorinated biphenyl derivatives by fungi leads to the formation of chlorinated lactone derivatives. Sietmann, R., Gesell, M., Hammer, E., Schauer, F. Chemosphere (2006) [Pubmed]
  8. Comparative toxicokinetics of 2,2'- and 4,4'-dichlorobiphenyls in the pond snail Lymnaea stagnalis (L.). Wilbrink, M., Treskes, M., De Vlieger, T.A., Vermeulen, N.P. Arch. Environ. Contam. Toxicol. (1990) [Pubmed]
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