The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

PCB-126     1,2,3-trichloro-5-(3,4- dichlorophenyl)benzene

Synonyms: PCB126, CHEMBL342696, SureCN308662, CCRIS 8862, AG-G-02778, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PCB 126


High impact information on PCB 126


Chemical compound and disease context of PCB 126


Biological context of PCB 126


Anatomical context of PCB 126


Associations of PCB 126 with other chemical compounds


Gene context of PCB 126

  • None of the AHR ligands tested, i.e. TCDD, benzo[a]pyrene, 3,3',4,4',5-pentachlorobiphenyl, beta-naphthoflavone, or alpha-naphthoflavone, bound to ER alpha [29].
  • CYP1 and AhR expression in 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma of rats prenatally exposed to 3,3',4,4',5-pentachlorobiphenyl [30].
  • Previous research from our laboratory has shown a switch-like response to PCB 126 mediated CYP1A1 induction in primary rat hepatocytes and in H4IIE rat hepatoma cells [31].
  • When the sea bass were treated with either 10 or 100 microg/kg PCB 126, an AhR ligand not yet tested in vivo in fish to assess its anti-estrogenicity, a modest and selective induction of EROD and DT-diaphorase activities was observed [32].
  • The objective of this research was to examine the time- and dose- dependent disturbances in the hypothalamic-pituitary-thyroid (HPT) axis of adult male rats administered a potent coplanar (non-ortho) PCB, 3,3',4,4',5-pentachlorobiphenyl (PCB 126) [33].

Analytical, diagnostic and therapeutic context of PCB 126


  1. Role of oxidative stress and antioxidant defense in 3,3',4,4',5-pentachlorobiphenyl-induced toxicity and species-differential sensitivity in chicken and duck embryos. Jin, X., Kennedy, S.W., Di Muccio, T., Moon, T.W. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  2. Single cell analysis of switch-like induction of CYP1A1 in liver cell lines. Broccardo, C.J., Billings, R.E., Chubb, L.S., Andersen, M.E., Hanneman, W.H. Toxicol. Sci. (2004) [Pubmed]
  3. Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers. Dean, C.E., Benjamin, S.A., Chubb, L.S., Tessari, J.D., Keefe, T.J. Toxicol. Sci. (2002) [Pubmed]
  4. Low-frequency hearing loss following perinatal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in rats. Crofton, K.M., Rice, D.C. Neurotoxicology and teratology. (1999) [Pubmed]
  5. Effects of some persistent halogenated environmental contaminants on aromatase (CYP19) activity in the human choriocarcinoma cell line JEG-3. Drenth, H.J., Bouwman, C.A., Seinen, W., Van den Berg, M. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  6. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells. Boverhof, D.R., Tam, E., Harney, A.S., Crawford, R.B., Kaminski, N.E., Zacharewski, T.R. Mol. Pharmacol. (2004) [Pubmed]
  7. Endocrine disruptive effects of polychlorinated aromatic hydrocarbons on intestinal cholecystokinin in rats. Lee, H.M., He, Q., Englander, E.W., Greeley, G.H. Endocrinology (2000) [Pubmed]
  8. Alteration in expression of gap junction proteins in rat liver after treatment with the tumour promoter 3,4,5,3',4'-pentachlorobiphenyl. Bager, Y., Kenne, K., Krutovskikh, V., Mesnil, M., Traub, O., Wärngård, L. Carcinogenesis (1994) [Pubmed]
  9. Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls. Tithof, P.K., Watts, S., Ganey, P.E. Biochem. Pharmacol. (1997) [Pubmed]
  10. Polychlorinated biphenyls modulate protooncogene expression in Chang liver cells. Hornhardt, S., Jenke, H.S., Michel, G. FEBS Lett. (1994) [Pubmed]
  11. Characterization of bronchiolar metaplasia of the alveolar epithelium in female Sprague-Dawley rats exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126). Brix, A.E., Jokinen, M.P., Walker, N.J., Sells, D.M., Nyska, A. Toxicologic pathology. (2004) [Pubmed]
  12. Toxicity and 7-ethoxyresorufin O-deethylase-inducing potency of coplanar polychlorinated biphenyls (PCBs) in chick embryos. Brunström, B., Andersson, L. Arch. Toxicol. (1988) [Pubmed]
  13. Biomonitoring of persistent organochlorine pesticides, PCDD/PCDFs and dioxin-like PCBs in blood of children from South West Germany (Baden-Wuerttemberg) from 1993 to 2003. Link, B., Gabrio, T., Zoellner, I., Piechotowski, I., Paepke, O., Herrmann, T., Felder-Kennel, A., Maisner, V., Schick, K.H., Schrimpf, M., Schwenk, M., Wuthe, J. Chemosphere (2005) [Pubmed]
  14. Method for evaluation of immunotoxicity of dioxin compounds using human T-lymphoblastic cell line, L-MAT. Kikuchi, H., Shibazaki, M., Ahmed, S., Baba, T. Chemosphere (2001) [Pubmed]
  15. Interaction of tributyltin with 3,3',4,4',5-pentachlorobiphenyl-induced ethoxyresorufin O-deethylase activity in rat hepatoma cells. Kannan, K., Villeneuve, D.L., Blankenship, A.L., Giesy, J.P. J. Toxicol. Environ. Health Part A (1998) [Pubmed]
  16. Elevation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) polychlorinated biphenyls. Structure-activity relationships. Denomme, M.A., Leece, B., Li, A., Towner, R., Safe, S. Biochem. Pharmacol. (1986) [Pubmed]
  17. Inductive effect on hepatic enzymes and toxicity of congeners of PCBs and PCDFs. Yoshimura, H., Yoshihara, S., Koga, N., Nagata, K., Wada, I., Kuroki, J., Hokama, Y. Environ. Health Perspect. (1985) [Pubmed]
  18. Effect of exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) throughout gestation and lactation on development and spatial delayed alternation performance in rats. Rice, D.C. Neurotoxicology and teratology. (1999) [Pubmed]
  19. Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3, 3',4,4',5-pentachlorobiphenyl. Ikeda, M., Ishii, Y., Kato, H., Akazawa, D., Hatsumura, M., Ishida, T., Matsusue, K., Yamada, H., Oguri, K. Arch. Biochem. Biophys. (2000) [Pubmed]
  20. Induction of CYP1A1 in primary rat hepatocytes by 3,3',4,4',5-pentachlorobiphenyl: evidence for a switch circuit element. French, C.T., Hanneman, W.H., Chubb, L.S., Billings, R.E., Andersen, M.E. Toxicol. Sci. (2004) [Pubmed]
  21. Purification and characterization of a newly identified isoform of cytochrome P450 responsible for 3-hydroxylation of 2,5,2',5'-tetrachlorobiphenyl in hamster liver. Koga, N., Kikuichi-Nishimura, N., Hara, T., Harada, N., Ishii, Y., Yamada, H., Oguri, K., Yoshimura, H. Arch. Biochem. Biophys. (1995) [Pubmed]
  22. Increased tumor necrosis factor-alpha production by peripheral blood leukocytes from TCDD-exposed rhesus monkeys. Rier, S.E., Coe, C.L., Lemieux, A.M., Martin, D.C., Morris, R., Lucier, G.W., Clark, G.C. Toxicol. Sci. (2001) [Pubmed]
  23. Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines. Bemis, J.C., Nazarenko, D.A., Gasiewicz, T.A. Toxicol. Sci. (2005) [Pubmed]
  24. Characterization of cardiotoxicity induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin and related chemicals during early chick embryo development. Walker, M.K., Catron, T.F. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  25. Subchronic effects of 2,3,7,8-TCDD or PCBs on thyroid hormone metabolism: use in risk assessment. Van Birgelen, A.P., Smit, E.A., Kampen, I.M., Groeneveld, C.N., Fase, K.M., Van der Kolk, J., Poiger, H., Van den Berg, M., Koeman, J.H., Brouwer, A. Eur. J. Pharmacol. (1995) [Pubmed]
  26. Effects of the antiestrogenic environmental pollutant 3,3',4,4', 5-pentachlorobiphenyl (PCB #126) in rat bone and uterus: diverging effects in ovariectomized and intact animals. Lind, P.M., Eriksen, E.F., Sahlin, L., Edlund, M., Orberg, J. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  27. Effects of maternal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-hexachlorobiphenyl (PCB169) on testicular steroidogenesis and spermatogenesis in male offspring rats. Yamamoto, M., Narita, A., Kagohata, M., Shirai, M., Akahori, F., Arishima, K. J. Androl. (2005) [Pubmed]
  28. Characterization of trophic transfer for polychlorinated dibenzo-p-dioxins, dibenzofurans, non- and mono-ortho polychlorinated biphenyls in the marine food web of Bohai Bay, North China. Wan, Y., Hu, J., Yang, M., An, L., An, W., Jin, X., Hattori, T., Itoh, M. Environ. Sci. Technol. (2005) [Pubmed]
  29. The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements. Klinge, C.M., Bowers, J.L., Kulakosky, P.C., Kamboj, K.K., Swanson, H.I. Mol. Cell. Endocrinol. (1999) [Pubmed]
  30. CYP1 and AhR expression in 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma of rats prenatally exposed to 3,3',4,4',5-pentachlorobiphenyl. Wakui, S., Yokoo, K., Takahashi, H., Muto, T., Suzuki, Y., Kanai, Y., Hano, H., Furusato, M., Endou, H. Toxicology (2005) [Pubmed]
  31. Probing the control elements of the CYP1A1 switching module in H4IIE hepatoma cells. Broccardo, C.J., Billings, R.E., Andersen, M.E., Hanneman, W.H. Toxicol. Sci. (2005) [Pubmed]
  32. Effects of 17beta-estradiol, 4-nonylphenol and PCB 126 on the estrogenic activity and phase 1 and 2 biotransformation enzymes in male sea bass (Dicentrarchus labrax). Vaccaro, E., Meucci, V., Intorre, L., Soldani, G., Di Bello, D., Longo, V., Gervasi, P.G., Pretti, C. Aquat. Toxicol. (2005) [Pubmed]
  33. Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat. Fisher, J.W., Campbell, J., Muralidhara, S., Bruckner, J.V., Ferguson, D., Mumtaz, M., Harmon, B., Hedge, J.M., Crofton, K.M., Kim, H., Almekinder, T.L. Toxicol. Sci. (2006) [Pubmed]
  34. Effects of perinatal exposure to low doses of PCB 153 and PCB 126 on lymphocyte proliferation and hematology in goat kids. Lyche, J., Larsen, H., Skaare, J.U., Tverdal, A., Dahl, E., Johansen, G., Ropstad, E. J. Toxicol. Environ. Health Part A (2004) [Pubmed]
  35. Change of bone tissue composition and impaired bone strength in rats exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126). Lind, P.M., Larsson, S., Oxlund, H., Hâkansson, H., Nyberg, K., Eklund, T., Orberg, J. Toxicology (2000) [Pubmed]
  36. A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver. Matsusue, K., Ishii, Y., Ariyoshi, N., Oguri, K. Toxicol. Lett. (1997) [Pubmed]
  37. Significant induction of a 54-kDa protein in rat liver with homologous alignment to mouse selenium binding protein by a coplanar polychlorinated biphenyl, 3,4,5,3',4'-pentachlorobiphenyl and 3-methylcholanthrene. Ishii, Y., Hatsumura, M., Ishida, T., Ariyoshi, N., Oguri, K. Toxicol. Lett. (1996) [Pubmed]
WikiGenes - Universities