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Chemical Compound Review

p,p-Dcbp     1-chloro-4-(4- chlorophenyl)benzene

Synonyms: CHEMBL14295, SureCN28215, NSC-1141, PCB 15, AG-E-50376, ...
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Disease relevance of Polychlorobiphenyl


High impact information on Polychlorobiphenyl


Chemical compound and disease context of Polychlorobiphenyl


Biological context of Polychlorobiphenyl


Anatomical context of Polychlorobiphenyl


Associations of Polychlorobiphenyl with other chemical compounds


Gene context of Polychlorobiphenyl

  • Edible portions of 12 marine organisms from several areas of the Adriatic Sea, Italy, were collected during Spring 1997 and analysed for 32 organochlorine pesticides residues and 27 polychlorobiphenyl congeners [25].
  • Four hydroxylated polychlorobiphenyl derivatives, a group of chiral and isomeric catchecins, and chiral binaphthyl compounds were also separated with CDM-beta-CD [26].
  • Polychlorobiphenyl (PCBs) levels and hepatic xenobiotic metabolizing enzyme activities were measured in fish from three locations of the River Rhône to study the consequences of a constant loading of PCBs from a PCB incineration plant [27].
  • Three surfactants (Brij 35, Tween 80, and SDS) and three organic solvents (acetone, triethylamine, and squalane) were used to evaluate the desorption performances of 4,4'-dichlorobiphenyl (DCB) out of three soils with different sorption characteristics [28].
  • Pretreatment of rats by phenobarbital or polychlorobiphenyl induced markedly the nuclei-dependent binding of AFB1 to DNA as well as the drug-metabolizing enzymes, such as aminopyrine-N-demethylase and epoxide hydratase [29].

Analytical, diagnostic and therapeutic context of Polychlorobiphenyl


  1. Analysis of three 2,3-dihydroxybiphenyl 1,2-dioxygenases found in Rhodococcus globerulus P6. Identification of a new family of extradiol dioxygenases. Asturias, J.A., Eltis, L.D., Prucha, M., Timmis, K.N. J. Biol. Chem. (1994) [Pubmed]
  2. Conversion of chlorobiphenyls into phenylhexadienoates and benzoates by the enzymes of the upper pathway for polychlorobiphenyl degradation encoded by the bph locus of Pseudomonas sp. strain LB400. Seeger, M., Timmis, K.N., Hofer, B. Appl. Environ. Microbiol. (1995) [Pubmed]
  3. Bacterial dehalogenation of chlorobenzoates and coculture biodegradation of 4,4'-dichlorobiphenyl. Adriaens, P., Kohler, H.P., Kohler-Staub, D., Focht, D.D. Appl. Environ. Microbiol. (1989) [Pubmed]
  4. Regiospecificity of dioxygenation of di- to pentachlorobiphenyls and their degradation to chlorobenzoates by the bph-encoded catabolic pathway of Burkholderia sp. strain LB400. Seeger, M., Zielinski, M., Timmis, K.N., Hofer, B. Appl. Environ. Microbiol. (1999) [Pubmed]
  5. Plant compounds that induce polychlorinated biphenyl biodegradation by Arthrobacter sp. strain B1B. Gilbert, E.S., Crowley, D.E. Appl. Environ. Microbiol. (1997) [Pubmed]
  6. Metabolism and activation of aflatoxin B1 by reconstituted cytochrome P-450 system of rat liver. Yoshizawa, H., Uchimaru, R., Kamataki, T., Kato, R., Ueno, Y. Cancer Res. (1982) [Pubmed]
  7. Characterization of the genes encoding a receptor-like histidine kinase and a cognate response regulator from a biphenyl/polychlorobiphenyl-degrading bacterium, Rhodococcus sp. strain M5. Labbé, D., Garnon, J., Lau, P.C. J. Bacteriol. (1997) [Pubmed]
  8. Degradation of 4,4'-dichlorobiphenyl, 3,3',4,4'-tetrachlorobiphenyl, and 2,2',4,4',5,5'-hexachlorobiphenyl by the white rot fungus Phanerochaete chrysosporium. Dietrich, D., Hickey, W.J., Lamar, R. Appl. Environ. Microbiol. (1995) [Pubmed]
  9. Analysis of Pseudomonas gene products using lacIq/Ptrp-lac plasmids and transposons that confer conditional phenotypes. de Lorenzo, V., Eltis, L., Kessler, B., Timmis, K.N. Gene (1993) [Pubmed]
  10. Cloning and expression of genes involved in 4-chlorobiphenyl transformation by Pseudomonas testosteroni: homology to polychlorobiphenyl-degrading genes in other bacteria. Ahmad, D., Massé, R., Sylvestre, M. Gene (1990) [Pubmed]
  11. Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes. Hayes, M.A., Roberts, E., Jago, M.V., Safe, S.H., Farber, E., Cameron, R.C. Journal of toxicology and environmental health. (1984) [Pubmed]
  12. Mediating role of metabolic activation in in vitro cytotoxicity assays. Babich, H., Martin-Alguacil, N., Borenfreund, E. Molecular toxicology. (1987) [Pubmed]
  13. The hydroxylation, dechlorination, and glucuronidation of 4,4'-dichlorobiphenyl (4-DCB) by human hepatic microsomes. Schnellmann, R.G., Volp, R.F., Putnam, C.W., Sipes, I.G. Biochem. Pharmacol. (1984) [Pubmed]
  14. Metabolism-related spectral characterization and subcellular distribution of polychlorinated biphenyl congeners in isolated rat hepatocytes. Vickers, A.E., Sipes, I.G., Brendel, K. Biochem. Pharmacol. (1986) [Pubmed]
  15. Reactor design and kinetics study of 4,4'-dichlorobiphenyl photodecay in surfactant solution by using a photosensitizer and hydrogen source. Chu, W., Kwan, C.Y. Water Res. (2003) [Pubmed]
  16. Biological and physical factors affecting the body burden of organic contaminants in freshwater mussels. Muncaster, B.W., Hebert, P.D., Lazar, R. Arch. Environ. Contam. Toxicol. (1990) [Pubmed]
  17. Relation of Lake Ontario fish consumption, lifetime lactation, and parity to breast milk polychlorobiphenyl and pesticide concentrations. Kostyniak, P.J., Stinson, C., Greizerstein, H.B., Vena, J., Buck, G., Mendola, P. Environmental research. (1999) [Pubmed]
  18. Suppression of serum adrenal cortex hormones by chronic low-dose polychlorobiphenyl or polybromobiphenyl treatments. Byrne, J.J., Carbone, J.P., Pepe, M.G. Arch. Environ. Contam. Toxicol. (1988) [Pubmed]
  19. Induction of porphyrin synthesis in chick embryo liver cell culture by synthetic polychlorobiphenyl isomers. Kawanishi, S., Mizutani, T., Sano, S. Biochim. Biophys. Acta (1978) [Pubmed]
  20. Screening the oxidative potential of several mono- and di-halogenated biphenyls and biphenyl ethers in rat hepatocytes. Gurer-Orhan, H., Orhan, H., Vermeulen, N.P., Meerman, J.H. Comb. Chem. High Throughput Screen. (2006) [Pubmed]
  21. Photodegradation of organic pollutants on the spruce needle wax surface under laboratory conditions. Dolinová, J., Klánová, J., Klán, P., Holoubek, I. Chemosphere (2004) [Pubmed]
  22. Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4'-dichlorobiphenyl, phenobarbitone and pregnenolone-16-alpha-carbonitrile. van Bree, L., Groot, E.J., De Vries, J. J. Pharm. Pharmacol. (1989) [Pubmed]
  23. The presence of glass beads or Triton X-100 in the medium enhances the aerobic dechlorination of Aroclor 1221 in Pseudomonas sp. CPE1 culture. Fava, F. Chemosphere (1996) [Pubmed]
  24. Polychlorobiphenyl (PCB) congeners in striped bass (Morone saxatilis) from marine and estuarine waters of New York State determined by capillary gas chromatography. Bush, B., Streeter, R.W., Sloan, R.J. Arch. Environ. Contam. Toxicol. (1990) [Pubmed]
  25. Organochlorine pesticides and polychlorinated biphenyls in 12 edible marine organisms from the Adriatic Sea, Italy, Spring 1997. Di Muccio, A., Stefanelli, P., Funari, E., Barbini, D.A., Generali, T., Pelosi, P., Girolimetti, S., Amendola, G., Vanni, F., Di Muccio, S. Food additives and contaminants. (2002) [Pubmed]
  26. Evaluation of newly synthesized and commercially available charged cyclomaltooligosaccharides (cyclodextrins) for capillary electrokinetic chromatography. Culha, M., Schell, F.M., Fox, S., Green, T., Betts, T., Sepaniak, M.J. Carbohydr. Res. (2004) [Pubmed]
  27. Effects of chemical pollution on the activities of hepatic xenobiotic metabolizing enzymes in fish from the River Rhône. Monod, G., Devaux, A., Riviere, J.L. Sci. Total Environ. (1988) [Pubmed]
  28. Remediation of contaminated soil by a solvent/surfactant system. Chu, W., Kwan, C.Y. Chemosphere (2003) [Pubmed]
  29. Nuclear envelope-dependent binding of aflatoxin B1 to DNA. Yoshizawa, H., Uchimaru, R., Ito, T., Tashiro, F., Ueno, Y. J. Environ. Pathol. Toxicol. Oncol. (1990) [Pubmed]
  30. Evaluation of the polychlorobiphenyl Aroclor 1254 in an animal model of atherosclerosis. Carter, J.W., Koo, S.I. Arch. Environ. Contam. Toxicol. (1988) [Pubmed]
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