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Chemical Compound Review:

ACMC-1AIYF tetrachloroplatinum

Synonyms: AG-D-70572, HSDB 6346, NSC-175496, NSC-271963, NSC-271964, ...

Teicher, B.A. et al., Ara, G. et al., Waters, M.D. et al., Losa, J.H. et al., Friedman, M.E. et al., et al.

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Disease relevance of tetrachloroplatinum

Photosensitization of crystalline and amorphous titanium dioxide by platinum(IV) chloride surface complexes [1].
Toxicity after self-poisoning by ingestion of potassium chloroplatinite [2].

High impact information on tetrachloroplatinum

Furthermore, other platinum compounds such as transplatin and platinum (IV) chloride can induce activation of p38 MAPK [3].
Alveolar macrophages were exposed in tissue culture for 20 hr to platinum dioxide (PtO2) or platinum tetrachloride (PtCl4) [4].
A complex of platinum tetrachloride with two molecules of rhodamine-123 (Rh-123), Pt(Rh-123)2, has been reported to act as hypoxic cell radiosensitizer of carcinoma cells in vitro and in vivo [5].
Elemental analysis showed that both the Nile Blue and Neutral Red complexes with tetrachloroplatinum (II) comprised 2 mol of dye and 1 mol of tetrachloroplatinum, forming Pt(Nile Blue)2 and Pt(Neutral Red)2 [6].
The effects of tetrachloroplatinum (II) ions on guinea pig peritoneal exudate neutrophil (heterophil) granulocytes [7].

Biological context of tetrachloroplatinum

Protection of the active site of mitochondrial malate dehydrogenase from inhibition by potassium tetrachloroplatinate [8].

References

Photosensitization of crystalline and amorphous titanium dioxide by platinum(IV) chloride surface complexes. Macyk, W., Kisch, H. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
Toxicity after self-poisoning by ingestion of potassium chloroplatinite. Woolf, A.D., Ebert, T.H. J. Toxicol. Clin. Toxicol. (1991) [Pubmed]
Role of the p38 MAPK pathway in cisplatin-based therapy. Losa, J.H., Parada Cobo, C., Cobo, C.P., Viniegra, J.G., Sánchez-Arevalo Lobo, V.J., Ramón y Cajal, S., Sánchez-Prieto, R. Oncogene (2003) [Pubmed]
Toxicity of platinum (IV) salts for cells of pulmonary origin. Waters, M.D., Vaughan, T.O., Abernethy, D.J., Garland, H.R., Cox, C.C., Coffin, D.L. Environ. Health Perspect. (1975) [Pubmed]
Multiple modality treatment of carcinoma cells with Pt(Rh-123)2 plus x-ray plus light. Ara, G., Varshney, A., Ha, C.S., Oseroff, A.R., Herman, T.S., Teicher, B.A. Photochem. Photobiol. (1992) [Pubmed]
DNA interaction, cytotoxicity, and radiosensitization with PtCl4(Nile Blue)2 and PtCl4(Neutral Red)2. Teicher, B.A., Herman, T.S., Kaufmann, M.E. Radiat. Res. (1989) [Pubmed]
The effects of tetrachloroplatinum (II) ions on guinea pig peritoneal exudate neutrophil (heterophil) granulocytes. Godlewski, A., Brzeziński, P.M., Litwin, J.A. Folia Histochem. Cytobiol. (1999) [Pubmed]
Protection of the active site of mitochondrial malate dehydrogenase from inhibition by potassium tetrachloroplatinate. Friedman, M.E., Otwell, H.B., Teggins, J.E. Biochim. Biophys. Acta (1975) [Pubmed]

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