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Chemical Compound Review

SureCN38832     N2,N2,N4,N6,N6-pentamethyl- 1,3,5-triazine...

Synonyms: AGN-PC-00FSNE, CHEMBL457723, NCIMech_000088, CCG-35281, PMM HCl, ...
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Disease relevance of PENTAMETHYLMELAMINE

  • Biochemical studies on the ability of pentamethylmelamine to interact in vivo with DNA and proteins in a sensitive murine ovarian reticular cell sarcoma [1].

High impact information on PENTAMETHYLMELAMINE


Biological context of PENTAMETHYLMELAMINE


Anatomical context of PENTAMETHYLMELAMINE




Analytical, diagnostic and therapeutic context of PENTAMETHYLMELAMINE


  1. Biochemical studies on the ability of pentamethylmelamine to interact in vivo with DNA and proteins in a sensitive murine ovarian reticular cell sarcoma. Garattini, E., Broggini, M., Coccia, P., Colombo, T., Rossi, C., D'Incalci, M. Biochem. Pharmacol. (1984) [Pubmed]
  2. Low oral bioavailability of hexamethylmelamine in the rat due to simultaneous hepatic and intestinal metabolism. Klippert, P.J., Hulshoff, A., Mingels, M.J., Hofman, G., Noordhoek, J. Cancer Res. (1983) [Pubmed]
  3. Uptake and metabolism of hexamethylmelamine and pentamethylmelamine by L5178Y lymphoblasts in vitro. Begleiter, A., Grover, J., Goldenberg, G.J. Cancer Res. (1980) [Pubmed]
  4. Pharmacokinetics and metabolism of hexamethylmelamine in mice bearing renal cell tumors. Dubois, J., Atassi, G., Hanocq, M., Abikhalil, F. Cancer Chemother. Pharmacol. (1988) [Pubmed]
  5. Preclinical toxicology, pharmacokinetics and formulation of N2,N4,N6-trihydroxymethyl-N2,N4,N6-trimethylmelamine (trimelamol), a water-soluble cytotoxic s-triazine which does not require metabolic activation. Rutty, C.J., Judson, I.R., Abel, G., Goddard, P.M., Newell, D.R., Harrap, K.R. Cancer Chemother. Pharmacol. (1986) [Pubmed]
  6. Distribution, metabolism, and irreversible binding of hexamethylmelamine in mice bearing ovarian carcinoma. Garattini, E., Colombo, T., Donelli, M.G., Catalani, P., Bianchi, M., D'Incalci, M., Pantarotto, C. Cancer Chemother. Pharmacol. (1983) [Pubmed]
  7. The comparative pharmacokinetics of pentamethylmelamine in man, rat, and mouse. Rutty, C.J., Newell, D.R., Muindi, J.R., Harrap, K.R. Cancer Chemother. Pharmacol. (1982) [Pubmed]
  8. Selected anticancer drugs in Phase I trials in the United States (1979--1980). Muggia, F.M., Penta, J.S., Catane, R., Jensen-Akula, M.S., Charles, L.M. Recent Results Cancer Res. (1981) [Pubmed]
  9. Human central nervous system pharmacology of pentamethylmelamine and its metabolites. Stewart, D.J., Benvenuto, J.A., Leavens, M., Smith, R.G., Cabanillas, F., Benjamin, R.S., Loo, T.L. J. Neurooncol. (1983) [Pubmed]
  10. Absorption and metabolism of hexamethylmelamine and pentamethylmelamine in rat everted perfused gut segments: correlation with in-vivo data. Borm, P.J., Frankhuyzen-Sierevogel, A.C., Weller, E.B., Noordhoek, J. J. Pharm. Pharmacol. (1985) [Pubmed]
  11. Phase I and pharmacological studies of pentamethylmelamine administered by 24-hour intravenous infusion. Casper, E.S., Gralla, R.J., Lynch, G.R., Jones, B.R., Woodcock, T.M., Gordon, C., Kelsen, D.P., Young, C.W. Cancer Res. (1981) [Pubmed]
  12. Specific determination of pentamethylmelamine and its demethylated metabolites in human plasma by high pressure liquid chromatography. Leyland-Jones, B.R., Deesen, P.E., Casper, E.S., Young, C.W. Therapeutic drug monitoring. (1982) [Pubmed]
  13. Determination of pentamethylmelamine and hexamethylmelamine in plasma and urine by nitrogen-phosphorus gas-liquid chromatography. Ames, M.M., Powis, G. J. Chromatogr. (1979) [Pubmed]
  14. Analogues of hexamethylmelamine. The anti-neoplastic activity of derivatives with enhanced water solubility. Cumber, A.J., Ross, W.C. Chem. Biol. Interact. (1977) [Pubmed]
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