Disease relevance of NSC46261

• An adverse reaction was seen in 1 patient of the clemizol-penicillin G group (allergic penicillin exanthema) [1].

High impact information on NSC46261

• Tone induced with KCl in guinea-pig isolated colon was not modified by histamine agonists even in tissues pretreated with clemizole or ranitidine [2].
• The application of capillary electrophoresis for separation of benzylpenicillin, procaine, benzathine and clemizole was investigated [3].
• The DA turnover was reduced remarkably by diphenhydramine, tripelennamine, and promethazine, and also significantly by chlorpheniramine, mepyramine, clemizole, and homochlorcyclizine, at doses used in the ordinary animal experiments [4].
• When the uterus was precontracted with KCl, histamine at lower doses produced a slight contraction, though in the presence of clemizole it induced concentration-related relaxation, reminiscent of that produced by adrenaline [5].

References