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Chemical Compound Review

Anthisan     N-[(4-methoxyphenyl)methyl]- N',N'-dimethyl...

Synonyms: Anhistol, Antamine, Histacap, Histalon, Histasan, ...
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Disease relevance of Pyranisamine


Psychiatry related information on Pyranisamine


High impact information on Pyranisamine


Chemical compound and disease context of Pyranisamine


Biological context of Pyranisamine


Anatomical context of Pyranisamine

  • (ii) Simultaneous administration of H1 and H2 histamine receptor antagonists (pyrilamine and famotidine, respectively) greatly diminishes recruitment and adhesion of both neutrophils (<20% of control) and monocytes/macrophages (<30% of control) to implants [22].
  • The neurotoxin tetrodotoxin (100 micrograms/kg i.v.) abolished the depressor response to spinal cord stimulation, whereas treatment with propranolol (0.5 mg/kg per minute i.v.), atropine (0.05 mg/kg per minute i.v.), or a combination of pyrilamine (0.5 mg/kg per minute i.v.) and cimetidine (0.5 mg/kg per minute i.v.) did not affect the response [23].
  • However, platelet-activating factor induces a slowly developing, sustained contractile wave in ileum that is not inhibited by an antihistaminic compound, pyrilamine, whereas C3a and C5a stimulate rapid transient contraction that is abrogated by the antihistamine [24].
  • The antihistamine mepyramine, administered orally, inhibited vasopermeability but not basophil degranulation [25].
  • Greater inhibition with pyrilamine was seen in IBD small intestine but its effect was less in IBD colon [26].

Associations of Pyranisamine with other chemical compounds

  • The PAF receptor antagonist WEB 2086 (2 mg/kg i.v.), the H1 blocker pyrilamine (10 mg/kg i.v.), and leukocyte depletion with cyclophosphamide (150 mg/kg i.p.) completely abolished the PAF priming effect [27].
  • Binding was competitively displaced by N alpha-MeHA (IC50 = 5.8 +/- 0.7 nM), (R) alpha-MeHA (IC50 = 9 +/- 1 nM), and thioperamide (IC50 = 85 +/- 10 nM), but not by famotidine (H2 antagonist) or by mepyramine (H1 antagonist) [28].
  • Furthermore, the increase in total immunoreactive LTB in mepyramine-treated FFD animals was significantly greater than the increase in LTB4 in mepyramine-treated BFD guinea pigs at 2 to 8 min after antigen challenge (p less than 0.05) [29].
  • Pretreatment with the H1 antagonist mepyramine and the H2 antagonist cimetidine caused a similar reduction in SP-induced PPE in main bronchi of both strains [30].
  • A consequence of the slow dissociation at 4 degrees is that the IC50 for mepyramine inhibition of promethazine-sensitive [3H]mepyramine binding at 4 degrees is independent of the concentration of [3H]mepyramine if the cerebellar homogenate is first incubated with the nonradioactive antagonist before addition of the 3H-ligand [31].

Gene context of Pyranisamine


Analytical, diagnostic and therapeutic context of Pyranisamine


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  28. Purification of a histamine H3 receptor negatively coupled to phosphoinositide turnover in the human gastric cell line HGT1. Cherifi, Y., Pigeon, C., Le Romancer, M., Bado, A., Reyl-Desmars, F., Lewin, M.J. J. Biol. Chem. (1992) [Pubmed]
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  30. Characterization of neurogenic inflammation in the airways of two highly inbred rat strains. Germonpré, P.R., Joos, G.F., Everaert, E., Kips, J.C., Pauwels, R.A. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
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