Disease relevance of AIDS221829

• In conclusion, R126638 is an interesting new triazole with high activity against the Malassezia yeasts, which are involved in pityriasis versicolor and seborrhoeic dermatitis [1].

High impact information on AIDS221829

• The decreased synthesis of ergosterol and the concomitant accumulation of 14 alpha-methylsterols provide indirect evidence that R126638 inhibits the activity of CYP51 that catalyzes the oxidative removal of the 14 alpha-methyl group of lanosterol or eburicol [2].
• The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis [2].
• With the agar dilution technique, minimal inhibitory concentrations were lower for R126638 compared with ketoconazole against Malassezia globosa, M. obtusa, M. slooffiae, M. restricta and two strains of M. sympodialis [1].
• The in vitro activity of a new triazole R126638 against Malassezia yeasts was compared with that of ketoconazole [1].

Associations of AIDS221829 with other chemical compounds

• Scanning electron microscopy did not reveal obvious surface differences between untreated cultures and cultures exposed to ketoconazole or R126638 in the concentration range 0.01-1 microg/ml [1].

Analytical, diagnostic and therapeutic context of AIDS221829

• In animal models of dermatophyte infections, R126638 showed superior antifungal activity [2].
• The corneofungimetry bioassay was performed on these CSSS to assess the antifungal profile of R126638 [3].

References