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Chemical Compound Review

NSC-46380     6-sulfanylidene-7,9-dihydro- 3H-purine-2,8...

Synonyms: AC1MHU36, NSC46380, NSC 46380, AKOS006273461, AKOS015904793, ...
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High impact information on NSC 46380


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Analytical, diagnostic and therapeutic context of NSC 46380


  1. Cysteine S-conjugates may act as kidney-selective prodrugs: formation of 6-mercaptopurine by the renal metabolism of S-(6-purinyl)-L-cysteine. Hwang, I.Y., Elfarra, A.A. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
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  4. Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase - enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different. Tamta, H., Kalra, S., Thilagavathi, R., Chakraborti, A.K., Mukhopadhyay, A.K. Biochemistry Mosc. (2007) [Pubmed]
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  7. Milk could decrease the bioavailability of 6-mercaptopurine. Rivard, G.E., Lin, K.T., Leclerc, J.M., David, M. The American journal of pediatric hematology/oncology. (1989) [Pubmed]
  8. Effect of allopurinol on the pharmacokinetics of 6-mercaptopurine in rabbits. Tterlikkis, L., Day, J.L., Brown, D.A., Schroeder, E.C. Cancer Res. (1983) [Pubmed]
  9. HPLC analysis of azathioprine metabolites in red blood cells, plasma and urine in renal transplant recipients. Weller, S., Thürmann, P., Rietbrock, N., Gossmann, J., Scheuermann, E.H. International journal of clinical pharmacology and therapeutics. (1995) [Pubmed]
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