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Chemical Compound Review

NSC-46380     6-sulfanylidene-7,9-dihydro- 3H-purine-2,8...

Synonyms: AC1MHU36, NSC46380, NSC 46380, AKOS006273461, AKOS015904793, ...
 
 
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Analytical, diagnostic and therapeutic context of NSC 46380

References

  1. Cysteine S-conjugates may act as kidney-selective prodrugs: formation of 6-mercaptopurine by the renal metabolism of S-(6-purinyl)-L-cysteine. Hwang, I.Y., Elfarra, A.A. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  2. Intestinal absorption and metabolism of 6-mercaptopurine in the rat small intestine. Ravis, W.R., Wang, J.S., Feldman, S. Biochem. Pharmacol. (1984) [Pubmed]
  3. HPLC analysis of 6-mercaptopurine and metabolites in extracellular body fluids. Rudy, J.L., Argyle, J.C., Winick, N., Van Dreal, P. Ann. Clin. Biochem. (1988) [Pubmed]
  4. Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase - enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different. Tamta, H., Kalra, S., Thilagavathi, R., Chakraborti, A.K., Mukhopadhyay, A.K. Biochemistry Mosc. (2007) [Pubmed]
  5. Assessment of exposure to chloramphenicol and azathioprine among workers in a South African pharmaceutical plant. Jeebhay, M., Mbuli, S., Uebel, R. International archives of occupational and environmental health. (1993) [Pubmed]
  6. In vitro oxidation of 6-MP and its metallo complexes by xanthine oxidase. Lewis, R.W., Olivier, G. Res. Commun. Chem. Pathol. Pharmacol. (1977) [Pubmed]
  7. Milk could decrease the bioavailability of 6-mercaptopurine. Rivard, G.E., Lin, K.T., Leclerc, J.M., David, M. The American journal of pediatric hematology/oncology. (1989) [Pubmed]
  8. Effect of allopurinol on the pharmacokinetics of 6-mercaptopurine in rabbits. Tterlikkis, L., Day, J.L., Brown, D.A., Schroeder, E.C. Cancer Res. (1983) [Pubmed]
  9. HPLC analysis of azathioprine metabolites in red blood cells, plasma and urine in renal transplant recipients. Weller, S., Thürmann, P., Rietbrock, N., Gossmann, J., Scheuermann, E.H. International journal of clinical pharmacology and therapeutics. (1995) [Pubmed]
  10. The use of xanthine oxidase for a specific and sensitive fluorimetric determination of 6-mercaptopurine in serum. Tawa, R., Takeshima, S., Hirose, S. Biochemical medicine. (1984) [Pubmed]
 
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