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Chemical Compound Review

AC1LOQXR     6-sulfanylidene-3,7- dihydropurin-2-one

Synonyms: CHEMBL1426, SureCN218972, SureCN833645, AG-E-46525, ANW-45333, ...
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Disease relevance of NSC 12160


High impact information on NSC 12160


Chemical compound and disease context of NSC 12160


Biological context of NSC 12160


  1. Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy. Ono, Y., Ikeda, K., Wei, M.X., Harsh, G.R., Tamiya, T., Chiocca, E.A. Hum. Gene Ther. (1997) [Pubmed]
  2. Retrovirally transduced Escherichia coli gpt genes combine selectability with chemosensitivity capable of mediating tumor eradication. Mroz, P.J., Moolten, F.L. Hum. Gene Ther. (1993) [Pubmed]
  3. Identification and characterization of differentiation mutants in the protozoan parasite Toxoplasma gondii. Matrajt, M., Donald, R.G., Singh, U., Roos, D.S. Mol. Microbiol. (2002) [Pubmed]
  4. Suicide gene transduction sensitizes murine embryonic and human mesenchymal stem cells to ablation on demand-- a fail-safe protection against cellular misbehavior. Fareed, M.U., Moolten, F.L. Gene Ther. (2002) [Pubmed]
  5. Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine. Tamiya, T., Ono, Y., Wei, M.X., Mroz, P.J., Moolten, F.L., Chiocca, E.A. Cancer Gene Ther. (1996) [Pubmed]
  6. Toxoplasma gondii: mechanism of the parasitostatic action of 6-thioxanthine. Pfefferkorn, E.R., Bzik, D.J., Honsinger, C.P. Exp. Parasitol. (2001) [Pubmed]
  7. Toxoplasma gondii: characterization of a mutant resistant to 6-thioxanthine. Pfefferkorn, E.R., Borotz, S.E. Exp. Parasitol. (1994) [Pubmed]
  8. Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase - enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different. Tamta, H., Kalra, S., Thilagavathi, R., Chakraborti, A.K., Mukhopadhyay, A.K. Biochemistry Mosc. (2007) [Pubmed]
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