The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mesentery

  • Therefore, MCP-1 was superfused over the mesentery of naive rats or rats with chronic adjuvant-induced vasculitis [1].
  • Despite widespread dissemination, visible metastases generally occur only in the brain, adrenals, kidneys, ovaries, pancreas, and mesentery [2].
  • Malignant lymphoma of the gastrointestinal tract and mesentery. A clinico-pathologic study of the significance of histologic classification. NHL Study Group of the Comprehensive Cancer Center West [3].
  • Intravital microscopic approaches were used to quantify leukocyte/endothelial cell interactions and venular protein leakage in rat mesenteries exposed to either 20 min ischemia and 60 min reperfusion (I/R), oxidants generated by the reaction of hypoxanthine and xanthine oxidase (HX/XO), platelet-activating factor (PAF), or leukotriene B4 (LTB4) [4].
  • 2. In fifteen N rats, acute hypoxia (breathing 6% O2 for 3 min) induced mean increases in the diameter of arterial vessels of mesentery (whose internal diameter was 10-350 microns) of 8.0 +/- 1.9% (mean +/- S.E.M.) and of venous vessels (whose internal diameter was 12-360 microns) of 10.4 +/- 2.6% [5].

High impact information on Mesentery

  • Isolated PGCs are associated with cells from the mesentery and with fibronectin [6].
  • Extravasation and interstitial tissue migration of PMNs was induced in the rat mesentery by chemotactic stimulation with platelet-activating factor (PAF; 10(-7) M) [7].
  • Superfusion of the mesentery with histamine (10(-7)-10(-5) M) resulted in a dose-related increase in the number of rolling leukocytes, a reduction in rolling velocity, and an increased clearance of FITC-labeled rat albumin from blood to superfusate [8].
  • As documented by intravital microscopy of small venules in the rabbit mesentery and tenuissimus muscle, leukocyte rolling was rapidly and profoundly reduced by intravenous treatment with the polysaccharide fucoidin, a homopolymer of sulfated L-fucose known to block the function of the leukocytic "rolling receptor" L-selectin [9].
  • In the in situ blood-perfused rat mesentery, in normal rats exogenous AII potentiated mesenteric vascular responses to periarterial (sympathetic) nerve stimulation (PNS) more than vascular responses to exogenous norepinephrine (NE) [10].

Chemical compound and disease context of Mesentery

  • Moreover, in rats that breathed 6% O2 for 3 or 20 min, the number of leakage sites was not changed in either mesentery or spinotrapezius by hypoxia, but was substantially increased in both preparations by topical application of histamine [11].
  • Radiologic findings in the gastrointestinal tract included superficial or deep mucosal ulcerations, perforation or fistula formation, luminal narrowing, rigidity and thickening of the intestinal wall, and inflammatory infiltration of the mesentery [12].
  • Changes in vessel diameter were recorded before and after local blockade of alpha-adrenoreceptors with phentolamine when the mesentery was covered with Saran Wrap, which is impermeable to O2, and then after removal of the Saran Wrap, which would have kept local PO2 relatively high even during systemic hypoxia [13].
  • These studies revealed a mobile gallium-avid solid abdominal mass subsequently proven to be an inflammatory pseudotumor of the mesentery, a rare benign mass [14].
  • BACKGROUND: Crohn's disease ileal ulcers and indomethacin-induced jejunal ulceration in the rat tend to occur in the mucosa nearest to the mesentery (mesenteric margin), an area of the bowel wall that has a critical blood supply [15].

Biological context of Mesentery

  • In WKY, 3 mg/kg captopril failed to significantly lower mean arterial blood pressure (MAP) and also failed to have a significant effect on the frequency-response curve to sympathetic nerve stimulation or dose-response curve to norepinephrine (NE) in the mesentery of WKY [16].
  • Chemical renal medullectomy prevents frusemide-induced inhibition of sympathetic vasoconstriction in the in situ blood perfused rat mesentery [17].
  • Orosomucoid, or alpha 1-acid glycoprotein, a serum protein known to be an "acute phase reactant" has recently been shown to be needed for the maintenance of normal capillary permeability in skeletal muscle and mesentery [18].
  • Sixty-minute superfusion of the rat mesentery with 1 nM Ang-II induced a significant increase in the leukocyte-endothelial cell interactions and P-selectin up-regulation, which were inhibited by 1 microM BM and SB [19].
  • However, the number of leucocytes that adhered to the inside of venular walls was significantly increased in both mesentery and spinotrapezius by a 3 min inhalation 6% O2 from 2.83(SEM 0.56) to 4.66(1.77) per 100 microns length of venule and from 2.44(0.33) to 3.35(0.49) respectively during the first period of hypoxia [11].

Anatomical context of Mesentery


Associations of Mesentery with chemical compounds


Gene context of Mesentery


Analytical, diagnostic and therapeutic context of Mesentery


  1. Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1. Johnston, B., Burns, A.R., Suematsu, M., Issekutz, T.B., Woodman, R.C., Kubes, P. J. Clin. Invest. (1999) [Pubmed]
  2. B16 melanoma metastasis to an "artificial organ" implant. Stackpole, C.W., Valle, E.F., Alterman, A.L. Cancer Res. (1991) [Pubmed]
  3. Malignant lymphoma of the gastrointestinal tract and mesentery. A clinico-pathologic study of the significance of histologic classification. NHL Study Group of the Comprehensive Cancer Center West. van Krieken, J.H., Otter, R., Hermans, J., van Groningen, K., Spaander, P.J., van de Sandt, M.M., Keuning, J.F., Kluin, P.M. Am. J. Pathol. (1989) [Pubmed]
  4. Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. Shigematsu, S., Ishida, S., Hara, M., Takahashi, N., Yoshimatsu, H., Sakata, T., Korthuis, R.J. Free Radic. Biol. Med. (2003) [Pubmed]
  5. The role of adenosine in mediating vasodilatation in mesenteric circulation of the rat in acute and chronic hypoxia. Mian, R., Marshall, J.M. J. Physiol. (Lond.) (1995) [Pubmed]
  6. Primordial germ cells of Xenopus embryos: the role of fibronectin in their adhesion during migration. Heasman, J., Hynes, R.O., Swan, A.P., Thomas, V., Wylie, C.C. Cell (1981) [Pubmed]
  7. beta1 integrins are critically involved in neutrophil locomotion in extravascular tissue In vivo. Werr, J., Xie, X., Hedqvist, P., Ruoslahti, E., Lindbom, L. J. Exp. Med. (1998) [Pubmed]
  8. Role of H1 receptors and P-selectin in histamine-induced leukocyte rolling and adhesion in postcapillary venules. Asako, H., Kurose, I., Wolf, R., DeFrees, S., Zheng, Z.L., Phillips, M.L., Paulson, J.C., Granger, D.N. J. Clin. Invest. (1994) [Pubmed]
  9. Inhibition of leukocyte rolling with polysaccharide fucoidin prevents pleocytosis in experimental meningitis in the rabbit. Granert, C., Raud, J., Xie, X., Lindquist, L., Lindbom, L. J. Clin. Invest. (1994) [Pubmed]
  10. Angiotensin II-noradrenergic interactions in renovascular hypertensive rats. Zimmerman, J.B., Robertson, D., Jackson, E.K. J. Clin. Invest. (1987) [Pubmed]
  11. Effect of acute systemic hypoxia on vascular permeability and leucocyte adherence in the anaesthetised rat. Mian, R., Marshall, J.M. Cardiovasc. Res. (1993) [Pubmed]
  12. Cytomegalovirus infection of the alimentary canal: radiologic findings with pathologic correlation. Teixidor, H.S., Honig, C.L., Norsoph, E., Albert, S., Mouradian, J.A., Whalen, J.P. Radiology. (1987) [Pubmed]
  13. Analysis of responses observed in mesenteric microcirculation of the rat during systemic hypoxia. Langdown, A.J., Marshall, J.M. J. Physiol. (Lond.) (1995) [Pubmed]
  14. Inflammatory pseudotumor: a gallium-avid mobile mesenteric mass. Auringer, S.T., Scott, M.D., Sumner, T.E. J. Nucl. Med. (1991) [Pubmed]
  15. The colonic mesenteric margin is most susceptible to injury in an experimental model of colonic ulceration. Anthony, A., Dhillon, A.P., Pounder, R.E., Wakefield, A.J. Aliment. Pharmacol. Ther. (1999) [Pubmed]
  16. Effects of captopril on vascular noradrenergic transmission in SHR. Eikenburg, D.C. Hypertension (1984) [Pubmed]
  17. Chemical renal medullectomy prevents frusemide-induced inhibition of sympathetic vasoconstriction in the in situ blood perfused rat mesentery. Gerkens, J.F., Armsworth, S.J., Bhagwandeen, S.B., Smith, A.J. J. Hypertens. (1987) [Pubmed]
  18. Glomerular permselectivity is dependent on adequate serum concentrations of orosomucoid. Haraldsson, B.S., Johnsson, E.K., Rippe, B. Kidney Int. (1992) [Pubmed]
  19. Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo. Estellés, R., Milian, L., Nabah, Y.N., Mateo, T., Cerdá-Nicolás, M., Losada, M., Ivorra, M.D., Issekutz, A.C., Cortijo, J., Morcillo, E.J., Blázquez, M.A., Sanz, M.J. J. Leukoc. Biol. (2005) [Pubmed]
  20. Effects of human neutrophil elastase (HNE) on neutrophil function in vitro and in inflamed microvessels. Woodman, R.C., Reinhardt, P.H., Kanwar, S., Johnston, F.L., Kubes, P. Blood (1993) [Pubmed]
  21. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Nilsson, M.B., Langley, R.R., Fidler, I.J. Cancer Res. (2005) [Pubmed]
  22. In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2. Pelton, R.W., Dickinson, M.E., Moses, H.L., Hogan, B.L. Development (1990) [Pubmed]
  23. Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium. Mukhopadhyay, D., Nagy, J.A., Manseau, E.J., Dvorak, H.F. Cancer Res. (1998) [Pubmed]
  24. Effects of thromboxane synthase inhibition on vascular responsiveness in the in vivo rat mesentery. Jackson, E.K. J. Clin. Invest. (1985) [Pubmed]
  25. Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. Arndt, H., Russell, J.B., Kurose, I., Kubes, P., Granger, D.N. Gastroenterology (1993) [Pubmed]
  26. Metronidazole inhibits leukocyte-endothelial cell adhesion in rat mesenteric venules. Arndt, H., Palitzsch, K.D., Grisham, M.B., Granger, D.N. Gastroenterology (1994) [Pubmed]
  27. Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. Asako, H., Kubes, P., Wallace, J., Wolf, R.E., Granger, D.N. Gastroenterology (1992) [Pubmed]
  28. Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. Davenpeck, K.L., Gauthier, T.W., Lefer, A.M. Gastroenterology (1994) [Pubmed]
  29. The anti-angiogenic VEGF isoform VEGF165b transiently increases hydraulic conductivity, probably through VEGF receptor 1 in vivo. Glass, C.A., Harper, S.J., Bates, D.O. J. Physiol. (Lond.) (2006) [Pubmed]
  30. Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton. Tribioli, C., Frasch, M., Lufkin, T. Mech. Dev. (1997) [Pubmed]
  31. Comparative studies with the endothelin receptor antagonists BQ-123 and PD 142893 indicate at least three endothelin receptors. Warner, T.D., Allcock, G.H., Mickley, E.J., Corder, R., Vane, J.R. J. Cardiovasc. Pharmacol. (1993) [Pubmed]
  32. The chemotactic response of tumor cells. A model for cancer metastasis. Lam, W.C., Delikatny, E.J., Orr, F.W., Wass, J., Varani, J., Ward, P.A. Am. J. Pathol. (1981) [Pubmed]
  33. L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Moore, P.K., al-Swayeh, O.A., Chong, N.W., Evans, R.A., Gibson, A. Br. J. Pharmacol. (1990) [Pubmed]
  34. Nitric oxide-mediated arteriolar dilation after endothelial deformation. Sun, D., Huang, A., Recchia, F.A., Cui, Y., Messina, E.J., Koller, A., Kaley, G. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  35. Thermotolerance induces heat shock protein 72 expression and protects against ischaemia-reperfusion-induced lung injury. Javadpour, M., Kelly, C.J., Chen, G., Stokes, K., Leahy, A., Bouchier-Hayes, D.J. The British journal of surgery. (1998) [Pubmed]
  36. Ependymin, a gene involved in regeneration and neuroplasticity in vertebrates, is overexpressed during regeneration in the echinoderm Holothuria glaberrima. Suárez-Castillo, E.C., Medina-Ortíz, W.E., Roig-López, J.L., García-Arrarás, J.E. Gene (2004) [Pubmed]
WikiGenes - Universities