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Chemical Compound Review

AC1MHYWV     2-amino-8-[4-(4- aminophenyl)phenyl]-9-[(2R...

Synonyms: dG-8-Abp
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Disease relevance of dG-8-Abp


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Biological context of dG-8-Abp


Anatomical context of dG-8-Abp


Analytical, diagnostic and therapeutic context of dG-8-Abp


  1. Quantification of N-(Deoxyguanosin-8-yl)-4-aminobiphenyl Adducts in Human Lymphoblastoid TK6 Cells Dosed with N-hydroxy-4-acetylaminobiphenyl and Their Relationship to Mutation, Toxicity, and Gene Expression Profiling. Ricicki, E.M., Luo, W., Fan, W., Zhao, L.P., Zarbl, H., Vouros, P. Anal. Chem. (2006) [Pubmed]
  2. Role of TP53 in repair of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human transitional cell carcinoma of the urinary bladder. Torino, J.L., Burger, M.S., Reznikoff, C.A., Swaminathan, S. Carcinogenesis (2001) [Pubmed]
  3. Adduct detection by acylation with [35S]methionine: analysis of DNA adducts of 4-aminobiphenyl. Sheabar, F.Z., Morningstar, M.L., Wogan, G.N. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. Specificity of mutagenesis by 4-aminobiphenyl. A possible role for N-(deoxyadenosin-8-yl)-4-aminobiphenyl as a premutational lesion. Lasko, D.D., Harvey, S.C., Malaikal, S.B., Kadlubar, F.F., Essigmann, J.M. J. Biol. Chem. (1988) [Pubmed]
  5. Specificity of mutagenesis by 4-aminobiphenyl: mutations at G residues in bacteriophage M13 DNA and G-->C transversions at a unique dG(8-ABP) lesion in single-stranded DNA. Verghis, S.B., Essigmann, J.M., Kadlubar, F.F., Morningstar, M.L., Lasko, D.D. Carcinogenesis (1997) [Pubmed]
  6. Metabolic activation of N-hydroxy-4-acetylaminobiphenyl by cultured human breast epithelial cell line MCF 10A. Swaminathan, S., Frederickson, S.M., Hatcher, J.F. Carcinogenesis (1994) [Pubmed]
  7. Comparative survival of aminobiphenyl- and aminofluorene-substituted plasmid DNA in Escherichia coli Uvr endonuclease deficient strains. Tamura, N., King, C.M. Carcinogenesis (1990) [Pubmed]
  8. Synthesis, characterization, and quantitation of a 4-aminobiphenyl-DNA adduct standard. Beland, F.A., Doerge, D.R., Churchwell, M.I., Poirier, M.C., Schoket, B., Marques, M.M. Chem. Res. Toxicol. (1999) [Pubmed]
  9. Detection and quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human pancreas tissue using capillary liquid chromatography-microelectrospray mass spectrometry. Ricicki, E.M., Soglia, J.R., Teitel, C., Kane, R., Kadlubar, F., Vouros, P. Chem. Res. Toxicol. (2005) [Pubmed]
  10. Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct. Talaska, G., al-Juburi, A.Z., Kadlubar, F.F. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  11. Mutagenic activation of 4-aminobiphenyl and its N-hydroxy derivatives by microsomes from cultured human uroepithelial cells. Hatcher, J.F., Rao, K.P., Swaminathan, S. Mutagenesis (1993) [Pubmed]
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