Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1MHYWV 2-amino-8-[4-(4- aminophenyl)phenyl]-9-[(2R...

Synonyms: dG-8-Abp

Ricicki, E.M. et al., Swaminathan, S. et al., Hatcher, J.F. et al., Talaska, G. et al., Verghis, S.B. et al., et al.

Beland, Doerge, Churchwell, Poirier, Schoket, Marques,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of dG-8-Abp

Quantification of N-(Deoxyguanosin-8-yl)-4-aminobiphenyl Adducts in Human Lymphoblastoid TK6 Cells Dosed with N-hydroxy-4-acetylaminobiphenyl and Their Relationship to Mutation, Toxicity, and Gene Expression Profiling [1].
Role of TP53 in repair of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human transitional cell carcinoma of the urinary bladder [2].

High impact information on dG-8-Abp

Acylation products of dGuo-8-ABP from all three sources showed HPLC retention times identical to those of authentic TBM-dGuo-8-ABP, and 35S incorporation into acylated products was linearly related to amount of adduct reacted [3].
The ability of the major carcinogen-DNA adduct formed by ABP in vivo and in vitro, N-(deoxyguanosin-8-yl)-4-aminobiphenyl, to cause base pair substitution mutations was also investigated [4].
A validated nano-LC microelectrospray mass spectrometry assay is reported for the detection and quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG-C8-ABP), the principal DNA adduct of 4-aminobiphenyl [1].
In order to further elucidate the mutagenic mechanism of ABP, an oligonucleotide containing the major DNA adduct, N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG(8-ABP)), was situated within the PstI site of a single-stranded M13 genome [5].
HPLC of the DNA hydrolysate obtained after incubation of [3H]N-OH-AABP and [3H]N-OH-ABP with the MCF 10A microsomes and cytosols showed N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG-ABP) as the primary adduct, based on the mobility of the radioactive peak in comparison with the synthetic standard [6].

Biological context of dG-8-Abp

Modification of plasmid DNA with N-acetoxy-N-trifluoroacetylaminobiphenyl yielded primarily N-(deoxyguanosin-8-yl)-4-aminobiphenyl residues [7].
HPLC analyses following enzymatic hydrolysis to nucleosides indicated one major adduct, N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG-C8-4-ABP) [8].

Anatomical context of dG-8-Abp

Detection and quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human pancreas tissue using capillary liquid chromatography-microelectrospray mass spectrometry [9].

Analytical, diagnostic and therapeutic context of dG-8-Abp

Moreover, when this adduct was eluted from the thin-layer chromatograms of several individuals and injected onto an HPLC system, the 32P from the human bladder DNA samples coeluted in the same fraction as the tritiated synthetic N-(deoxyguanosin-8-yl)-4-aminobiphenyl marker [10].
High pressure liquid chromatography (HPLC) of the DNA hydrolysate obtained after incubation of [3H]N-OH-ABP with YG1024, showed N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG-ABP) as the primary adduct, based on mobility of the radioactivity in comparison with the synthetic standard [11].

References

Quantification of N-(Deoxyguanosin-8-yl)-4-aminobiphenyl Adducts in Human Lymphoblastoid TK6 Cells Dosed with N-hydroxy-4-acetylaminobiphenyl and Their Relationship to Mutation, Toxicity, and Gene Expression Profiling. Ricicki, E.M., Luo, W., Fan, W., Zhao, L.P., Zarbl, H., Vouros, P. Anal. Chem. (2006) [Pubmed]
Role of TP53 in repair of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human transitional cell carcinoma of the urinary bladder. Torino, J.L., Burger, M.S., Reznikoff, C.A., Swaminathan, S. Carcinogenesis (2001) [Pubmed]
Adduct detection by acylation with [35S]methionine: analysis of DNA adducts of 4-aminobiphenyl. Sheabar, F.Z., Morningstar, M.L., Wogan, G.N. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
Specificity of mutagenesis by 4-aminobiphenyl. A possible role for N-(deoxyadenosin-8-yl)-4-aminobiphenyl as a premutational lesion. Lasko, D.D., Harvey, S.C., Malaikal, S.B., Kadlubar, F.F., Essigmann, J.M. J. Biol. Chem. (1988) [Pubmed]
Specificity of mutagenesis by 4-aminobiphenyl: mutations at G residues in bacteriophage M13 DNA and G-->C transversions at a unique dG(8-ABP) lesion in single-stranded DNA. Verghis, S.B., Essigmann, J.M., Kadlubar, F.F., Morningstar, M.L., Lasko, D.D. Carcinogenesis (1997) [Pubmed]
Metabolic activation of N-hydroxy-4-acetylaminobiphenyl by cultured human breast epithelial cell line MCF 10A. Swaminathan, S., Frederickson, S.M., Hatcher, J.F. Carcinogenesis (1994) [Pubmed]
Comparative survival of aminobiphenyl- and aminofluorene-substituted plasmid DNA in Escherichia coli Uvr endonuclease deficient strains. Tamura, N., King, C.M. Carcinogenesis (1990) [Pubmed]
Synthesis, characterization, and quantitation of a 4-aminobiphenyl-DNA adduct standard. Beland, F.A., Doerge, D.R., Churchwell, M.I., Poirier, M.C., Schoket, B., Marques, M.M. Chem. Res. Toxicol. (1999) [Pubmed]
Detection and quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human pancreas tissue using capillary liquid chromatography-microelectrospray mass spectrometry. Ricicki, E.M., Soglia, J.R., Teitel, C., Kane, R., Kadlubar, F., Vouros, P. Chem. Res. Toxicol. (2005) [Pubmed]
Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct. Talaska, G., al-Juburi, A.Z., Kadlubar, F.F. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
Mutagenic activation of 4-aminobiphenyl and its N-hydroxy derivatives by microsomes from cultured human uroepithelial cells. Hatcher, J.F., Rao, K.P., Swaminathan, S. Mutagenesis (1993) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.