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Chemical Compound Review

N-Hydroxy-aabp     N-hydroxy-N-(4- phenylphenyl)ethanamide

Synonyms: CHEMBL279548, CCRIS 1061, AG-F-56518, CHEBI:16434, LS-7441, ...
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Disease relevance of N-Hydroxy-aabp


High impact information on N-Hydroxy-aabp


Anatomical context of N-Hydroxy-aabp


Associations of N-Hydroxy-aabp with other chemical compounds


Gene context of N-Hydroxy-aabp


Analytical, diagnostic and therapeutic context of N-Hydroxy-aabp


  1. Quantification of N-(Deoxyguanosin-8-yl)-4-aminobiphenyl Adducts in Human Lymphoblastoid TK6 Cells Dosed with N-hydroxy-4-acetylaminobiphenyl and Their Relationship to Mutation, Toxicity, and Gene Expression Profiling. Ricicki, E.M., Luo, W., Fan, W., Zhao, L.P., Zarbl, H., Vouros, P. Anal. Chem. (2006) [Pubmed]
  2. Mutational signature of the proximate bladder carcinogen N-hydroxy-4-acetylaminobiphenyl: inconsistency with the p53 mutational spectrum in bladder cancer. Besaratinia, A., Bates, S.E., Pfeifer, G.P. Cancer Res. (2002) [Pubmed]
  3. p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion. van Gijssel, H.E., Maassen, C.B., Mulder, G.J., Meerman, J.H. Carcinogenesis (1997) [Pubmed]
  4. Metabolic activation of N-hydroxy-4-acetylaminobiphenyl by cultured human breast epithelial cell line MCF 10A. Swaminathan, S., Frederickson, S.M., Hatcher, J.F. Carcinogenesis (1994) [Pubmed]
  5. Microsome-mediated transacetylation and binding of N-hydroxy-4-aminobiphenyl to nucleic acids by hepatic and bladder tissues from dog. Hatcher, J.F., Swaminathan, S. Carcinogenesis (1992) [Pubmed]
  6. Sulfation-dependent formation of N-acetylated and deacetylated DNA adducts of N-hydroxy-4-acetylaminobiphenyl in male rat liver in vivo and in isolated hepatocytes. van de Poll, M.L., Venizelos, V., Meerman, J.H. Carcinogenesis (1990) [Pubmed]
  7. Comparison of acyltransferase-mediated mutagenicity and nucleic acid binding of N-acetoxy-4-acetylaminobiphenyl by hepatic and bladder microsomes from rats and dogs. Swaminathan, S., Hatcher, J.F. Environ. Mol. Mutagen. (1992) [Pubmed]
  8. Formation and removal of DNA adducts in rat liver treated with N-hydroxy derivatives of 2-acetylaminofluorene, 4-acetylaminobiphenyl, and 2-acetylaminophenanthrene. Gupta, R.C., Dighe, N.R. Carcinogenesis (1984) [Pubmed]
  9. Human urinary bladder epithelial cells lacking wild-type p53 function are deficient in the repair of 4-aminobiphenyl-DNA adducts in genomic DNA. Swaminathan, S., Torino, J.L., Burger, M.S. Mutat. Res. (2002) [Pubmed]
  10. Reductase activity of aldehyde oxidase toward the carcinogen N-hydroxy-2-acetylaminofluorene and the related hydroxamic acids. Kitamura, S., Sugihara, K., Tatsumi, K. Biochem. Mol. Biol. Int. (1994) [Pubmed]
  11. Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases. Hein, D.W., Doll, M.A., Rustan, T.D., Gray, K., Feng, Y., Ferguson, R.J., Grant, D.M. Carcinogenesis (1993) [Pubmed]
  12. Identification of N-(deoxyguanosin-8-yl)-4-azobiphenyl by (32)P-postlabeling analyses of DNA in human uroepithelial cells exposed to proximate metabolites of the environmental carcinogen 4-aminobiphenyl. Hatcher, J.F., Swaminathan, S. Environ. Mol. Mutagen. (2002) [Pubmed]
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