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Chemical Compound Review

Ascorbigen     (1S,5R,6S)-1,2,6-trihydroxy- 2-(1H-indol-3...

Synonyms: AC1MIWVS, CHEBI:64944, SureCN14163965, 8075-98-7, indol-3-ylmethyl-ascorbate
 
 
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Disease relevance of Ascorbigen

 

High impact information on Ascorbigen

 

Anatomical context of Ascorbigen

  • Experiments on Wistar rats showed that feeding a ration containing 0.1% concentrate of food indoles (indole-3-carbinole and ascorbigen) for 3 weeks increased activity of phases I and II xenobiotic metabolism enzymes in the liver and intestinal mucosa and weakened the toxic effects of trichothecene T-2 mycotoxin [7].
 

Analytical, diagnostic and therapeutic context of Ascorbigen

  • Incubated microsomes from rats pretreated with I3C and ascorbigen yielded high levels of 2-hydroxyestradiol (2-OHE2) that were comparable to levels induced by Bnf and were significantly above control group levels (p < 0.005) [6].

References

  1. Modulation of cytochrome P4501A1 activity by ascorbigen in murine hepatoma cells. Stephenson, P.U., Bonnesen, C., Bjeldanes, L.F., Vang, O. Biochem. Pharmacol. (1999) [Pubmed]
  2. The clastogenic and mutagenic effects of ascorbigen and 1'-methylascorbigen. Musk, S.R., Preobrazhenskaya, M.N., Belitsky, G.A., Korolev, A.M., Lytcheva, T.A., Khitrovo, I.A., Johnson, I.T. Mutat. Res. (1994) [Pubmed]
  3. The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Bramwell, B., Ferguson, S., Scarlett, N., Macintosh, A. Alternative medicine review : a journal of clinical therapeutic. (2000) [Pubmed]
  4. Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Bonnesen, C., Eggleston, I.M., Hayes, J.D. Cancer Res. (2001) [Pubmed]
  5. Ascorbigen and other indole-derived compounds from Brassica vegetables and their analogs as anticarcinogenic and immunomodulating agents. Preobrazhenskaya, M.N., Bukhman, V.M., Korolev, A.M., Efimov, S.A. Pharmacol. Ther. (1993) [Pubmed]
  6. Catechol estrogen production in rat microsomes after treatment with indole-3-carbinol, ascorbigen, or beta-naphthaflavone: a comparison of stable isotope dilution gas chromatography-mass spectrometry and radiometric methods. Sepkovic, D.W., Bradlow, H.L., Michnovicz, J., Murtezani, S., Levy, I., Osborne, M.P. Steroids (1994) [Pubmed]
  7. Effect of nutritional indoles on activity of xenobiotic metabolism enzymes and T-2 toxicity in rats. Kravchenko, L.V., Avren'eva, L.I., Guseva, G.V., Posdnyakov, A.L., Tutel'yan, V.A. Bull. Exp. Biol. Med. (2001) [Pubmed]
 
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