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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AGN-PC-00B1CH     10,11-dihydroxy- 2,2,6a,6b,9,9,12a...

Synonyms: AC1MW77E, A826411, 4373-41-5
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Disease relevance of Maslinic acid


High impact information on Maslinic acid


Biological context of Maslinic acid

  • Glaucacetalin A (3), excreted into the culture media, reached a maximum amount of 2.14 mg/L after 21 days while galphimine E (2) and maslinic acid (6) were recovered from the root biomasses reaching maximum concentrations of 0.11 and 0.43 mg/g, respectively, on day 39 [6].
  • In conclusion, maslinic acid may offer some advantages in the resistance of oxidative stress in the animals [7].
  • Among them, compound 2, (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide (5), and maslinic acid (6) showed significant inhibitory activities against human leukaemia cells CCRF-CEM and its multidrug-resistant sub-line, CEM/ADR5000, with IC50 values in a range of 7.1 to 29.7 microM [8].

Anatomical context of Maslinic acid


Associations of Maslinic acid with other chemical compounds


Analytical, diagnostic and therapeutic context of Maslinic acid

  • The production of three triterpenoids from Galphimia glauca hairy root cultures, the sedative principle galphimine E (2), the recently described glaucacetalin A (3), and maslinic acid (6), was quantified by HPLC in the biomass and the culture medium [6].


  1. (2alpha,3beta)-2,3-Dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. Reyes, F.J., Centelles, J.J., Lupi????ez, J.A., Cascante, M. FEBS Lett. (2006) [Pubmed]
  2. Anti-HIV triterpene acids from Geum japonicum. Xu, H.X., Zeng, F.Q., Wan, M., Sim, K.Y. J. Nat. Prod. (1996) [Pubmed]
  3. Maslinic acid as a feed additive to stimulate growth and hepatic protein-turnover rates in rainbow trout (Onchorhynchus mykiss). Fern??ndez-Navarro, M., Perag??n, J., Esteban, F.J., de la Higuera, M., Lupi????ez, J.A. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2006) [Pubmed]
  4. Olive Fruit Extracts Inhibit Proliferation and Induce Apoptosis in HT-29 Human Colon Cancer Cells. Juan, M.E., Wenzel, U., Ruiz-Gutierrez, V., Daniel, H., Planas, J.M. J. Nutr. (2006) [Pubmed]
  5. Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages. Márquez Martín, A., de la Puerta Vázquez, R., Fernández-Arche, A., Ruiz-Gutiérrez, V. Free Radic. Res. (2006) [Pubmed]
  6. Production of triterpenoids in liquid-cultivated hairy roots of Galphimia glauca. Nader, B.L., Taketa, A.T., Pereda-Miranda, R., Villarreal, M.L. Planta Med. (2006) [Pubmed]
  7. Antioxidant activity of maslinic acid, a triterpene derivative obtained from Olea europaea. Montilla, M.P., Agil, A., Navarro, M.C., Jiménez, M.I., García-Granados, A., Parra, A., Cabo, M.M. Planta Med. (2003) [Pubmed]
  8. New glycosides from Tetracentron sinense and their cytotoxic activity. Wang, Y.F., Lai, G.F., Efferth, T., Cao, J.X., Luo, S.D. Chem. Biodivers. (2006) [Pubmed]
  9. Pentacyclic triterpenes. Part 1: the first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. Wen, X., Sun, H., Liu, J., Wu, G., Zhang, L., Wu, X., Ni, P. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
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