The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AGN-PC-00B1CH     10,11-dihydroxy- 2,2,6a,6b,9,9,12a...

Synonyms: AC1MW77E, A826411, 4373-41-5
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Maslinic acid

 

High impact information on Maslinic acid

 

Biological context of Maslinic acid

  • Glaucacetalin A (3), excreted into the culture media, reached a maximum amount of 2.14 mg/L after 21 days while galphimine E (2) and maslinic acid (6) were recovered from the root biomasses reaching maximum concentrations of 0.11 and 0.43 mg/g, respectively, on day 39 [6].
  • In conclusion, maslinic acid may offer some advantages in the resistance of oxidative stress in the animals [7].
  • Among them, compound 2, (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide (5), and maslinic acid (6) showed significant inhibitory activities against human leukaemia cells CCRF-CEM and its multidrug-resistant sub-line, CEM/ADR5000, with IC50 values in a range of 7.1 to 29.7 microM [8].
 

Anatomical context of Maslinic acid

 

Associations of Maslinic acid with other chemical compounds

 

Analytical, diagnostic and therapeutic context of Maslinic acid

  • The production of three triterpenoids from Galphimia glauca hairy root cultures, the sedative principle galphimine E (2), the recently described glaucacetalin A (3), and maslinic acid (6), was quantified by HPLC in the biomass and the culture medium [6].

References

  1. (2alpha,3beta)-2,3-Dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. Reyes, F.J., Centelles, J.J., Lupi????ez, J.A., Cascante, M. FEBS Lett. (2006) [Pubmed]
  2. Anti-HIV triterpene acids from Geum japonicum. Xu, H.X., Zeng, F.Q., Wan, M., Sim, K.Y. J. Nat. Prod. (1996) [Pubmed]
  3. Maslinic acid as a feed additive to stimulate growth and hepatic protein-turnover rates in rainbow trout (Onchorhynchus mykiss). Fern??ndez-Navarro, M., Perag??n, J., Esteban, F.J., de la Higuera, M., Lupi????ez, J.A. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2006) [Pubmed]
  4. Olive Fruit Extracts Inhibit Proliferation and Induce Apoptosis in HT-29 Human Colon Cancer Cells. Juan, M.E., Wenzel, U., Ruiz-Gutierrez, V., Daniel, H., Planas, J.M. J. Nutr. (2006) [Pubmed]
  5. Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages. Márquez Martín, A., de la Puerta Vázquez, R., Fernández-Arche, A., Ruiz-Gutiérrez, V. Free Radic. Res. (2006) [Pubmed]
  6. Production of triterpenoids in liquid-cultivated hairy roots of Galphimia glauca. Nader, B.L., Taketa, A.T., Pereda-Miranda, R., Villarreal, M.L. Planta Med. (2006) [Pubmed]
  7. Antioxidant activity of maslinic acid, a triterpene derivative obtained from Olea europaea. Montilla, M.P., Agil, A., Navarro, M.C., Jiménez, M.I., García-Granados, A., Parra, A., Cabo, M.M. Planta Med. (2003) [Pubmed]
  8. New glycosides from Tetracentron sinense and their cytotoxic activity. Wang, Y.F., Lai, G.F., Efferth, T., Cao, J.X., Luo, S.D. Chem. Biodivers. (2006) [Pubmed]
  9. Pentacyclic triterpenes. Part 1: the first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. Wen, X., Sun, H., Liu, J., Wu, G., Zhang, L., Wu, X., Ni, P. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
 
WikiGenes - Universities