Disease relevance of Maslinic acid

• This study examines the response of HT29 and Caco-2 colon-cancer cell lines to maslinic-acid treatment [1].
• Moreover, maslinic acid induced cell differentiation in colon adenocarcinoma cells [1].
• Of these compounds, 1, ursolic acid, and maslinic acid showed potent inhibitory activity against HIV-1 protease [2].
• The total hepatic DNA or liver cell hyperplasia levels in trout fed with 25 and 250 mg of maslinic acid kg(-1) were 37% and 68% higher than controls [3].

High impact information on Maslinic acid

• However, maslinic acid did not alter the cell cycle or induce apoptosis in the non-tumoural intestine cell lines IEC-6 and IEC-18 [1].
• These findings support a role for maslinic acid as a tumour suppressant and as a possible new therapeutic tool for aberrant cell proliferation in the colon [1].
• We investigated the effect on cell proliferation and apoptosis in HT-29 cells of an extract from the skin of olives composed of pentacyclic triterpenes with the main components maslinic acid (73.25%) and oleanolic acid (25.75%) [4].
• At concentrations inhibiting cell growth by 50-80% (IC50HT29=61+/-1muM, IC80HT29=76+/-1muM and IC50Caco-2=85+/-5muM, IC80Caco-2=116+/-5muM), maslinic acid induced strong G0/G1 cell-cycle arrest and DNA fragmentation, and increased caspase-3 activity [1].
• Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages [5].

Biological context of Maslinic acid

• Glaucacetalin A (3), excreted into the culture media, reached a maximum amount of 2.14 mg/L after 21 days while galphimine E (2) and maslinic acid (6) were recovered from the root biomasses reaching maximum concentrations of 0.11 and 0.43 mg/g, respectively, on day 39 [6].
• In conclusion, maslinic acid may offer some advantages in the resistance of oxidative stress in the animals [7].
• Among them, compound 2, (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide (5), and maslinic acid (6) showed significant inhibitory activities against human leukaemia cells CCRF-CEM and its multidrug-resistant sub-line, CEM/ADR5000, with IC50 values in a range of 7.1 to 29.7 microM [8].

Anatomical context of Maslinic acid

• Co-incubation with maslinic acid prevented hepatocyte membrane LPO as shown by the reduction of TBARS [7].

Associations of Maslinic acid with other chemical compounds

• The semi-synthesis, in vitro and in vivo biological evaluation of corosolic acid (1) and maslinic acid (2) are described [9].

Analytical, diagnostic and therapeutic context of Maslinic acid

• The production of three triterpenoids from Galphimia glauca hairy root cultures, the sedative principle galphimine E (2), the recently described glaucacetalin A (3), and maslinic acid (6), was quantified by HPLC in the biomass and the culture medium [6].

References