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Chemical Compound Review

SureCN1157257     (1S,2R,4aS,6aR,6aS,6bR,10S,11R ,12aS,14bS)...

Synonyms: KST-1A5725, AC1L4WCO, AC1Q5QHO, AR-1A3712, LS-193275, ...
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Disease relevance of Corosolic acid


High impact information on Corosolic acid


Associations of Corosolic acid with other chemical compounds


Gene context of Corosolic acid


Analytical, diagnostic and therapeutic context of Corosolic acid

  • The results showed that 3H-glucose uptaking rate in different concentrations of corosolic acid (15mumol/L ,30mumol/L ,and 45mumol/L )group were increased to 108.1%, 112.2% ,118.6%, respectively, compared to control group (without corosolic acid) (p<0.01) [6].
  • The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes [8].


  1. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Yamaguchi, Y., Yamada, K., Yoshikawa, N., Nakamura, K., Haginaka, J., Kunitomo, M. Life Sci. (2006) [Pubmed]
  2. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. Judy, W.V., Hari, S.P., Stogsdill, W.W., Judy, J.S., Naguib, Y.M., Passwater, R. Journal of ethnopharmacology. (2003) [Pubmed]
  3. Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata. Na, M., Yang, S., He, L., Oh, H., Kim, B.S., Oh, W.K., Kim, B.Y., Ahn, J.S. Planta Med. (2006) [Pubmed]
  4. Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris. Ryu, S.Y., Oak, M.H., Yoon, S.K., Cho, D.I., Yoo, G.S., Kim, T.S., Kim, K.M. Planta Med. (2000) [Pubmed]
  5. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Ahn, K.S., Hahm, M.S., Park, E.J., Lee, H.K., Kim, I.H. Planta Med. (1998) [Pubmed]
  6. Corosolic acid isolation from the leaves of Eriobotrta japonica showing the effects on carbohydrate metabolism and differentiation of 3T3-L1 adipocytes. Zong, W., Zhao, G. Asia Pacific journal of clinical nutrition (2007) [Pubmed]
  7. Chemical constituents of Glechoma longituba. Yang, N.Y., Duan, J.A., Li, P., Qian, S.H. Yao Xue Xue Bao (2006) [Pubmed]
  8. Antidiabetic effects of corosolic acid in KK-Ay diabetic mice. Miura, T., Ueda, N., Yamada, K., Fukushima, M., Ishida, T., Kaneko, T., Matsuyama, F., Seino, Y. Biol. Pharm. Bull. (2006) [Pubmed]
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