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Chemical Compound Review:

SureCN1157257 (1S,2R,4aS,6aR,6aS,6bR,10S,11R ,12aS,14bS)...

Synonyms: KST-1A5725, AC1L4WCO, AC1Q5QHO, AR-1A3712, LS-193275, ...

Zong, W. et al., Ryu, S.Y. et al., Yang, N.Y. et al., Ahn, K.S. et al., Judy, W.V. et al., et al.

Zong, Zhao, Miura, Ueda, Yamada, Fukushima, Ishida, Kaneko, Matsuyama, Seino,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Corosolic acid

Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome [1].
The antidiabetic activity of an extract from the leaves of Lagerstroemia speciosa standardized to 1% corosolic acid (Glucosol) has been demonstrated in a randomized clinical trial involving Type II diabetics (non-insulin-dependent diabetes mellitus, NIDDM) [2].

High impact information on Corosolic acid

(Symplocaceae), using an in vitro PTP1B inhibitory assay, resulted in the isolation of three ursane-type triterpenes, ursolic acid (1), corosolic acid (2) and 2alpha,3alpha,19alpha,23-tetrahydroxyurs-12-en-28-oic acid (3) [3].
When the isolated compounds were tested for their effects on the production of nitric oxide from cultured murine macrophages, RAW 264.7 cells, ursolic acid and 2 alpha-hydroxyursolic acid exhibited strong inhibitory activities (IC50 values, 17 and 27 microM, respectively) [4].
Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent [5].
Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines [5].
Moreover, the effects of corosolic acid on carbohydrate metabolism and differentiation of 3T3-L1 adipocytes was studied [6].

Associations of Corosolic acid with other chemical compounds

RESULTS: Nine compounds were isolated from Glechoma longituba and identified, as: glecholone (1), 6R,9R-3-oxo-alpha-ionol (2), S(+)-dehydrovomifoliol (3), vomifoliol (4), corosolic acid (5), quercetin (6), stigmastenol (7), myristic acid (8) and triacontanol (9) [7].

Gene context of Corosolic acid

Corosolic acid promotes the 3H-glucose uptaking, suppresses the differentiation and downregulates the expression of PPAR-gamma and C/EBP-alpha mRNA in 3T3-L1 adipocytes [6].
Corosolic acid suppressed the differentiation of 3T3-L1 pre-adipocytes and down-regulated the expression of PPAR-gamma and C/EBP-alpha mRNA (p<0.01, vs control group) [6].

Analytical, diagnostic and therapeutic context of Corosolic acid

The results showed that 3H-glucose uptaking rate in different concentrations of corosolic acid (15mumol/L ,30mumol/L ,and 45mumol/L )group were increased to 108.1%, 112.2% ,118.6%, respectively, compared to control group (without corosolic acid) (p<0.01) [6].
The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes [8].

References

Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Yamaguchi, Y., Yamada, K., Yoshikawa, N., Nakamura, K., Haginaka, J., Kunitomo, M. Life Sci. (2006) [Pubmed]
Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. Judy, W.V., Hari, S.P., Stogsdill, W.W., Judy, J.S., Naguib, Y.M., Passwater, R. Journal of ethnopharmacology. (2003) [Pubmed]
Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata. Na, M., Yang, S., He, L., Oh, H., Kim, B.S., Oh, W.K., Kim, B.Y., Ahn, J.S. Planta Med. (2006) [Pubmed]
Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris. Ryu, S.Y., Oak, M.H., Yoon, S.K., Cho, D.I., Yoo, G.S., Kim, T.S., Kim, K.M. Planta Med. (2000) [Pubmed]
Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Ahn, K.S., Hahm, M.S., Park, E.J., Lee, H.K., Kim, I.H. Planta Med. (1998) [Pubmed]
Corosolic acid isolation from the leaves of Eriobotrta japonica showing the effects on carbohydrate metabolism and differentiation of 3T3-L1 adipocytes. Zong, W., Zhao, G. Asia Pacific journal of clinical nutrition (2007) [Pubmed]
Chemical constituents of Glechoma longituba. Yang, N.Y., Duan, J.A., Li, P., Qian, S.H. Yao Xue Xue Bao (2006) [Pubmed]
Antidiabetic effects of corosolic acid in KK-Ay diabetic mice. Miura, T., Ueda, N., Yamada, K., Fukushima, M., Ishida, T., Kaneko, T., Matsuyama, F., Seino, Y. Biol. Pharm. Bull. (2006) [Pubmed]

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