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Chemical Compound Review

Binedalina     N,N',N'-trimethyl-N-(3- phenylindol-1...

Synonyms: Binedaline, Binodalina, Binodaline, Binedalinum, Binodalinum, ...
 
 
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Disease relevance of Binedaline

 

Psychiatry related information on Binedaline

 

High impact information on Binedaline

  • Unlike these drugs binedaline did not show any significant affinity for an alpha adrenergic, muscarinic cholinergic, histamine H1 or serotonin2 (5-HT2) receptors [5].
  • Binedaline binding to plasma proteins and red blood cells in humans [6].
  • Binodaline, like placebo, had little effect on salivary output, whereas amitriptyline caused a dose-dependent decrease in salivation [7].
  • The desmethyl analogue of binodaline (Sgd 20578) also inhibited transmitter uptake into cerebral nerve endings, being more potent than the parent compound in inhibiting NA uptake (8.5 X 10 mol/l), of a similar potency with respect to 5-HT (3.2 X 10(-7) mol/l) and slightly less potent against DA (8.3 X 10(-6) mol/l) [8].
  • It has been shown, in extensive animal experiments, that 1-(omega-dimethylaminoethylmethyl)-amino-3-phenylindole hydrochloride (binodaline HCl, Sgd-Scha 1059), can be regarded as an antidepressant with novel characteristics [2].
 

Anatomical context of Binedaline

  • After 2 weeks of daily administration of binedaline (20 mg/kg i.p.), the number of beta adrenergic recognition sites labeled with [3H]CGP 12177 remained constant in rat forebrain, as did 5-HT2 receptors and benzodiazepine receptors [5].
  • It is concluded that binodaline owes its antidepressant activity at least in part to its ability to inhibit monoamine uptake into pre-synaptic cerebral nerve endings [8].

References

  1. A comparison of the cardiovascular effects and subjective tolerability of binedaline and amitriptylene in healthy volunteers. Joubert, P.H., Starke, D.D., Van Reenen, O., Venter, C.P. Eur. J. Clin. Pharmacol. (1985) [Pubmed]
  2. Pharmacological and toxicological studies of binodaline hydrochloride. Jahn, U., Adrian, R.W., Ismail, S., Michos, N. Arzneimittel-Forschung. (1983) [Pubmed]
  3. A controlled double-blind study comparing binedaline and imipramine in the treatment of endogenous depression. Faltus, F., Geerling, F.C. Neuropsychobiology (1984) [Pubmed]
  4. Acute effects on psychomotor performance of binedaline alone and with alcohol. Patat, A., Klein, M.J., Jones, R.W. Methods and findings in experimental and clinical pharmacology. (1988) [Pubmed]
  5. Pharmacological profile of binedaline, a new antidepressant drug. Morin, D., Zini, R., Urien, S., Tillement, J.P. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  6. Binedaline binding to plasma proteins and red blood cells in humans. Morin, D., Zini, R., Ledewyn, S., Colonna, J.P., Czajka, M., Tillement, J.P. Journal of pharmaceutical sciences. (1985) [Pubmed]
  7. Comparison of the effects of binodaline and amitriptyline on peripheral autonomic functions in healthy volunteers. Longmore, J., Szabadi, E., Bradshaw, C.M. British journal of clinical pharmacology. (1985) [Pubmed]
  8. Influence of the antidepressant binodaline on biogenic amine uptake and brain levels in the rat. Benfield, D.P., Luscombe, D.K. Arzneimittel-Forschung. (1983) [Pubmed]
 
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