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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Ergometry

  • Seventeen adult women with sickle cell anemia underwent symptom-limited maximal CPET using cycle ergometry and ramp protocols; blood gases and lactate concentrations were measured every 2 minutes [1].
  • Thallium images were obtained following stress both with dobutamine infusion (5-20 micrograms kg-1 min-1) and with symptom-limited bicycle ergometry in 20 patients (age 39-70 years) with chest pain who had been admitted for coronary angiography [2].
  • Fifty-seven men with stable angina pectoris underwent bicycle ergometry before and after long-acting nitrate or calcium antagonist therapy was instituted [3].
  • STUDY OBJECTIVE: To detect dynamic hyperinflation by comparing reduction in inspiratory capacity (IC) during both paced hyperventilation and cycle ergometry in patients with moderate-to-severe COPD, studied before and after acute bronchodilation [4].
  • RESULTS: Patients receiving RMET showed significant improvements in endurance exercise capacity (constant-load exercise on cycle ergometry; 18 min vs 28 min, p < 0.001), in perception of dyspnea (Borg score; 8.4 vs 5.4, p < 0.001), and respiratory muscle endurance capacity (sustainable inspiratory pressure; 25 cm H(2)O vs 31 cm H(2)O, p = 0.005) [5].

Psychiatry related information on Ergometry


High impact information on Ergometry

  • Oxygen uptake during shoveling was similar to that for arm ergometry (5.7 vs 6.3 metabolic equivalents), but lower than for treadmill testing (9.3 metabolic equivalents) [7].
  • To examine this hypothesis, we administered the nonselective beta-adrenergic receptor blocker propranolol (0.15 mg/kg IV) to 25 healthy normotensive men ages 28 to 72 years from the Baltimore Longitudinal Study of Aging (BLSA) immediately before maximal upright cycle ergometry with 99mTc gated cardiac blood pool scintigraphy [8].
  • Responses to constant work rate bicycle ergometry exercise in primary pulmonary hypertension: the effect of inhaled nitric oxide [9].
  • RESULTS: A corresponding CI was documented in 32 of 42 patients in a coronary sinus lactate study (reduced lactate extraction 5.6 +/- 4.1%) and in 29 of 40 patients in an ergometry (0.25 +/- 0.06 mV ST depressions) [10].
  • METHODS: Nineteen healthy volunteers with mean age 70 +/- 10 years underwent maximal-effort upright ergometry tests on two separate days after receiving either 0.15 mg/kg i.v. verapamil or 0.5 N saline in a double-blind, randomized, crossover study [11].

Chemical compound and disease context of Ergometry


Biological context of Ergometry

  • CONCLUSIONS: The G5920A mutation caused COX deficiency in muscle, explaining the exercise intolerance and the low muscle capacity for oxidative phosphorylation documented by cycle ergometry [17].
  • METHODS: Metabolic and ventilatory variables were measured breath by breath during submaximal cycle ergometry exercise performed at 50% of symptom limited achieved maximal load in 33 clinically stable patients with COPD (23 men) with forced expiratory volume in one second (FEV1) of 40 (12)% predicted [18].
  • For these purposes, glucose and glycerol kinetics were determined in eight men during rest and during 90 min of leg cycle ergometry at 45 and 65% of peak O2 consumption (.VO2 (peak)) [19].
  • Insertion/deletion polymorphism in the angiotensin-converting-enzyme gene and blood pressure during ergometry in normal males [20].
  • After consumption of caffeine or placebo, subjects either rested for 100 min (rest protocol) or rested for 45 min followed by 55 min of cycle ergometry at 65% of maximal oxygen consumption (exercise protocol) [21].

Anatomical context of Ergometry

  • In order to determine the role of the carotid bodies on the ventilatory control characteristics during the non-steady-state phase of exercise in man, six normal males performed cycle ergometry with four repetitions of a 6 min, constant-load work bout at inspired O2 fractions (FI,O2) of 0.12, 0.15, 0.21, 0.30 and 1.00 [22].
  • Estradiol treatment did not affect measurements of systolic function, diastolic function, left ventricular mass, or pulmonary artery pressure at rest or during bicycle ergometry [23].
  • Stress testing can be performed with exercise(treadmill, bicycle, or arm ergometry) or pharmacologic agents that increase cardiac work (dobutamine) or dilate the coronary vessels (adenosine or dipyridamole) [24].
  • To determine whether strenuous exercise could acutely change expression of CD39 in platelets and lymphocytes, eight healthy sedentary men, 34 yr old (SD 7), and eight physically active men, 34 yr old (SD 6), performed graded upright cycle ergometry to volitional exhaustion [25].
  • Blood flow to the lower extremity was measured and sampled for lactate, catecholamines, and oxygen content in 12 normal men at rest, at all stages of bicycle ergometry, and during the postexercise recovery period [26].

Associations of Ergometry with chemical compounds

  • To establish an alternative method of testing, 50 subjects (aged 56 +/- 10 years) performed arm ergometry testing in conjunction with myocardial thallium scintigraphy [27].
  • These subjects performed graded cycle ergometry to exhaustion, once breathing room air and once breathing a He-O2 gas mixture (79% He, 21% O2) [28].
  • Cortisol changes after bicycle ergometry revealed no impact of genetic factors on the secretion of cortisol in response to strenuous physical exercise [6].
  • METHODS AND RESULTS: We measured cardiac noradrenaline spillover at rest by a radiotracer technique and VO(2) peak, during cycle ergometry, by open circuit spirometry in 49 heart failure patients (mean age 54.4+/-1.4 (SE)) [29].
  • During ergometry, only delta % noradrenaline was greater in patients (P < 0.05). delta % for all other parameters were either of the same order as in controls, or blunted [30].

Gene context of Ergometry

  • METHODS: Patients with RA (n = 7), patients with SLE (n = 6) and healthy individuals (HI) (n = 10) performed incremental cycle ergometry to the limit of tolerance [31].
  • Six well-trained males completed three trials of 120 min of cycle ergometry at 70% peak O(2) consumption (Vo(2 peak); MOD) and 40% Vo(2 peak) with (LOW + IL-6) and without (LOW) infusion of recombinant human (rh)IL-6 [32].
  • Physical exercise increased plasma epinephrine by 374 +/- 123% and plasma norepinephrine by 167 +/- 30%, but plasma PP concentrations remained unchanged during standardized bicycle ergometry [33].
  • We examined effects of home-based inspiratory muscle training (IMT) and cycle ergometry training (CET) in 53 patients with moderate to severe COPD (FEV(1)% pred, 50 +/- 17 [mean +/- SD]) [34].
  • Eight healthy males performed cycle ergometry at 75% of VO2peak on three occasions after the administration of a placebo (PLACEBO), a prostaglandin inhibitor (indomethacin, INDO), and an angiotensin converting enzyme inhibitor (captopril, CAPTO) [35].

Analytical, diagnostic and therapeutic context of Ergometry


  1. Cardiopulmonary responses to exercise in women with sickle cell anemia. Callahan, L.A., Woods, K.F., Mensah, G.A., Ramsey, L.T., Barbeau, P., Gutin, B. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  2. A comparison of dobutamine and maximal exercise as stress for thallium scintigraphy. Wallbridge, D.R., Tweddel, A.C., Martin, W., Hutton, I. European journal of nuclear medicine. (1993) [Pubmed]
  3. Early positive exercise test and extensive coronary disease: effect of antianginal therapy. Mukharji, J., Kremers, M., Lipscomb, K., Blomqvist, C.G. Am. J. Cardiol. (1985) [Pubmed]
  4. Simplified detection of dynamic hyperinflation. Gelb, A.F., Gutierrez, C.A., Weisman, I.M., Newsom, R., Taylor, C.F., Zamel, N. Chest (2004) [Pubmed]
  5. Exercise performance improves in patients with COPD due to respiratory muscle endurance training. Koppers, R.J., Vos, P.J., Boot, C.R., Folgering, H.T. Chest (2006) [Pubmed]
  6. Heritability of cortisol responses to human corticotropin-releasing hormone, ergometry, and psychological stress in humans. Kirschbaum, C., Wüst, S., Faig, H.G., Hellhammer, D.H. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  7. Cardiac demands of heavy snow shoveling. Franklin, B.A., Hogan, P., Bonzheim, K., Bakalyar, D., Terrien, E., Gordon, S., Timmis, G.C. JAMA (1995) [Pubmed]
  8. Effects of acute beta-adrenergic receptor blockade on age-associated changes in cardiovascular performance during dynamic exercise. Fleg, J.L., Schulman, S., O'Connor, F., Becker, L.C., Gerstenblith, G., Clulow, J.F., Renlund, D.G., Lakatta, E.G. Circulation (1994) [Pubmed]
  9. Responses to constant work rate bicycle ergometry exercise in primary pulmonary hypertension: the effect of inhaled nitric oxide. Riley, M.S., Pórszász, J., Engelen, M.P., Shapiro, S.M., Brundage, B.H., Wasserman, K. J. Am. Coll. Cardiol. (2000) [Pubmed]
  10. Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms ("dilated coronopathy"). Krüger, D., Stierle, U., Herrmann, G., Simon, R., Sheikhzadeh, A. J. Am. Coll. Cardiol. (1999) [Pubmed]
  11. Verapamil acutely reduces ventricular-vascular stiffening and improves aerobic exercise performance in elderly individuals. Chen, C.H., Nakayama, M., Talbot, M., Nevo, E., Fetics, B., Gerstenblith, G., Becker, L.C., Kass, D.A. J. Am. Coll. Cardiol. (1999) [Pubmed]
  12. Effectiveness of salmeterol versus ipratropium bromide on exertional dyspnoea in COPD. Ayers, M.L., Mejia, R., Ward, J., Lentine, T., Mahler, D.A. Eur. Respir. J. (2001) [Pubmed]
  13. Cardiac stress testing with thallium-201 imaging reveals silent ischemia in individuals with paraplegia. Bauman, W.A., Raza, M., Spungen, A.M., Machac, J. Archives of physical medicine and rehabilitation. (1994) [Pubmed]
  14. Receptor binding of propranolol is the missing link between plasma concentration kinetics and the effect-time course in man. Wellstein, A., Palm, D., Pitschner, H.F., Belz, G.G. Eur. J. Clin. Pharmacol. (1985) [Pubmed]
  15. Cardiovascular responses during recovery from exercise and thermal stress. Kilgour, R.D., Gariépy, P., Rehel, R. Aviation, space, and environmental medicine. (1993) [Pubmed]
  16. Evaluation of cardiac ischaemia in cardiac asymptomatic newly diagnosed untreated patients with primary hypothyroidism. Roos, A., Zoet-Nugteren, S.K., Berghout, A. The Netherlands journal of medicine. (2005) [Pubmed]
  17. Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA. Karadimas, C.L., Greenstein, P., Sue, C.M., Joseph, J.T., Tanji, K., Haller, R.G., Taivassalo, T., Davidson, M.M., Shanske, S., Bonilla, E., DiMauro, S. Neurology (2000) [Pubmed]
  18. Decreased mechanical efficiency in clinically stable patients with COPD. Baarends, E.M., Schols, A.M., Akkermans, M.A., Wouters, E.F. Thorax (1997) [Pubmed]
  19. Autoregulation of glucose production in men with a glycerol load during rest and exercise. Trimmer, J.K., Casazza, G.A., Horning, M.A., Brooks, G.A. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  20. Insertion/deletion polymorphism in the angiotensin-converting-enzyme gene and blood pressure during ergometry in normal males. Friedl, W., Krempler, F., Sandhofer, F., Paulweber, B. Clin. Genet. (1996) [Pubmed]
  21. Effects of caffeine on blood pressure, heart rate, and forearm blood flow during dynamic leg exercise. Daniels, J.W., Molé, P.A., Shaffrath, J.D., Stebbins, C.L. J. Appl. Physiol. (1998) [Pubmed]
  22. Influence of inspired oxygen concentration on the dynamics of the exercise hyperpnoea in man. Griffiths, T.L., Henson, L.C., Whipp, B.J. J. Physiol. (Lond.) (1986) [Pubmed]
  23. Physiologic estradiol replacement therapy and cardiac structure and function in normal postmenopausal women: a randomized, double-blind, placebo-controlled, crossover trial. Snabes, M.C., Payne, J.P., Kopelen, H.A., Dunn, J.K., Young, R.L., Zoghbi, W.A. Obstetrics and gynecology. (1997) [Pubmed]
  24. Angina pectoris: evaluation in the office. Kelemen, M.D. Med. Clin. North Am. (2006) [Pubmed]
  25. Vigorous exercise acutely changes platelet and B-lymphocyte CD39 expression. Coppola, A., Coppola, L., dalla Mora, L., Limongelli, F.M., Grassia, A., Mastrolorenzo, L., Gombos, G., Lucivero, G. J. Appl. Physiol. (2005) [Pubmed]
  26. Hemodynamic and metabolic responses of the exercising lower limb of humans. Sullivan, M.J., Binkley, P.K., Unverferth, D.V., Leier, C.V. J. Lab. Clin. Med. (1987) [Pubmed]
  27. Arm exercise-thallium imaging testing for the detection of coronary artery disease. Balady, G.J., Weiner, D.A., Rothendler, J.A., Ryan, T.J. J. Am. Coll. Cardiol. (1987) [Pubmed]
  28. Breathing He-O2 increases ventilation but does not decrease the work of breathing during exercise. Babb, T.G. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  29. Peak oxygen uptake is not determined by cardiac noradrenaline spillover in heart failure. Notarius, C.F., Azevedo, E.R., Parker, J.D., Floras, J.S. Eur. Heart J. (2002) [Pubmed]
  30. Blunted humoral responses to mental stress and physical exercise in cardiac transplant recipients. Sehested, J., Reinicke, G., Ishino, K., Hetzer, R., Schifter, S., Schmitzer, E., Regitz, V. Eur. Heart J. (1995) [Pubmed]
  31. Serum cortisol reduction and abnormal prolactin and CD4+/CD8+ T-cell response as a result of controlled exercise in patients with rheumatoid arthritis and systemic lupus erythematosus despite unaltered muscle energetics. Pool, A.J., Whipp, B.J., Skasick, A.J., Alavi, A., Bland, J.M., Axford, J.S. Rheumatology (Oxford, England) (2004) [Pubmed]
  32. Recombinant human interleukin-6 infusion during low-intensity exercise does not enhance whole body lipolysis or fat oxidation in humans. Hiscock, N., Fischer, C.P., Sacchetti, M., van Hall, G., Febbraio, M.A., Pedersen, B.K. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  33. Role of circulating catecholamines in the control of pancreatic polypeptide and gastrin release. Mönnikes, H., Koop, H., Ehlenz, K., Dionysius, J., Arnold, R. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1989) [Pubmed]
  34. Cycle ergometer and inspiratory muscle training in chronic obstructive pulmonary disease. Larson, J.L., Covey, M.K., Wirtz, S.E., Berry, J.K., Alex, C.G., Langbein, W.E., Edwards, L. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  35. Exercise-induced proteinuria is attenuated by indomethacin. Mittleman, K.D., Zambraski, E.J. Medicine and science in sports and exercise. (1992) [Pubmed]
  36. Lung volume reduction surgery improves maximal O2 consumption, maximal minute ventilation, O2 pulse, and dead space-to-tidal volume ratio during leg cycle ergometry. Benditt, J.O., Lewis, S., Wood, D.E., Klima, L., Albert, R.K. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  37. Incidence, progression and functional significance of cardiac allograft vasculopathy after heart transplantation. Julius, B.K., Attenhofer Jost, C.H., Sütsch, G., Brunner, H.P., Kuenzli, A., Vogt, P.R., Turina, M., Hess, O.M., Kiowski, W. Transplantation (2000) [Pubmed]
  38. Detection of radiation-induced myocardial damage by technetium-99m sestamibi scintigraphy. Gyenes, G., Fornander, T., Carlens, P., Glas, U., Rutqvist, L.E. European journal of nuclear medicine. (1997) [Pubmed]
  39. Comparison and cross-validation of cycle ergometry estimates of VO2max. Lockwood, P.A., Yoder, J.E., Deuster, P.A. Medicine and science in sports and exercise. (1997) [Pubmed]
  40. Clinical profile and long-term prognosis of women < or = 50 years of age referred for coronary angiography for evaluation of chest pain. Gurevitz, O., Jonas, M., Boyko, V., Rabinowitz, B., Reicher-Reiss, H. Am. J. Cardiol. (2000) [Pubmed]
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