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Chemical Compound Review:

PubChem20946 1-[3-(trifluoromethyl) phenyl]piperazine

Synonyms: PIP077, CHEMBL274866, SureCN231692, AG-E-03624, SureCN6094745, ...

Glennon, R.A., Tsutsumi, H. et al., Mos, J. et al., Staack, R.F. et al., Herndon, J.L. et al., et al.

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Disease relevance of NSC 128882

Clonidine (an alpha 2-agonist) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, a 5-HT1A agonist) induced hyperphagia and 1-(3-trifluoromethylphenyl)piperazine (TFMPP, a 5-HT1B agonist) induced hypophagia dose-dependently in both rat lines [1].

Psychiatry related information on NSC 128882

Using a standard two-lever operant procedure with rats trained to discriminate 1-(3-trifluoromethylphenyl)piperazine (TFMPP) (0.5 mg/kg) from saline, tests of stimulus antagonism and stimulus generalization were performed to better understand the stimulus properties of this agent [2].

High impact information on NSC 128882

Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP). In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes [3].
In addition, the novel, selective 5-HT2C antagonist, SB 200,646A, failed to abolish HTW and the 5-HT2C agonists/5-HT2A antagonists, 1-(3-chlorophenyl)piperazine and 1-(3-trifluoromethylphenyl)piperazine, blocked, rather than elicited, HTW [4].
Studies are described on the phase I and II metabolism and the toxicological analysis of the piperazine-derived designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP) in rat urine using gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) [5].
The present study examined the effects of 8-OH-DPAT on the feeding suppressant action of the indirect 5-HT agonists fenfluramine (FEN; 0.63-2.5 mg/kg) and fluoxetine (FLU; 2.5-10 mg/kg), as well as the 5-HT1B/2C agonist 1-(3-trifluoromethylphenyl)piperazine (TFMPP; 0.5-2 mg/kg) [6].
To evaluate the role of somatodendritic 5-HT1A receptors in the mediation of aggressive behaviour, eltoprazine, TFMPP (1-(3-trifluoromethylphenyl)piperazine hydrochloride) and 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) were administered locally into the dorsal raphe nucleus of rats [7].

Associations of NSC 128882 with other chemical compounds

Development of simultaneous gas chromatography-mass spectrometric and liquid chromatography-electrospray ionization mass spectrometric determination method for the new designer drugs, N-benzylpiperazine (BZP), 1-(3-trifluoromethylphenyl)piperazine (TFMPP) and their main metabolites in urine [8].

Gene context of NSC 128882

Stimulus generalization occurs among these agents regardless of which is used as the training drug, although stimulus generalization does not occur with 5-HT1A-selective agonists [e.g., 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH DPAT)] or with 5-HT1B-selective agonists [e.g., 1-(3-trifluoromethylphenyl)piperazine (TFMPP)] [9].
The putative 5-HT1B agonist, 1-(3-trifluoromethylphenyl)piperazine (TFMPP), had a weak effect on the responses to DOI or 8-OHDPAT [10].

References

Hypothalamic monoamines and food intake in alcohol-preferring AA and alcohol-avoiding ANA rats. Korpi, E.R., Päivärinta, P., Sjöholm, B., Koulu, M. Alcohol (1991) [Pubmed]
Mechanistic investigation of the stimulus properties of 1-(3-trifluoromethylphenyl)piperazine. Herndon, J.L., Pierson, M.E., Glennon, R.A. Pharmacol. Biochem. Behav. (1992) [Pubmed]
Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP). In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes. Staack, R.F., Paul, L.D., Springer, D., Kraemer, T., Maurer, H.H. Biochem. Pharmacol. (2004) [Pubmed]
(1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists. Schreiber, R., Brocco, M., Audinot, V., Gobert, A., Veiga, S., Millan, M.J. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
New designer drug 1-(3-trifluoromethylphenyl) piperazine (TFMPP): gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry studies on its phase I and II metabolism and on its toxicological detection in rat urine. Staack, R.F., Fritschi, G., Maurer, H.H. Journal of mass spectrometry : JMS. (2003) [Pubmed]
Reversal of fenfluramine and fluoxetine anorexia by 8-OH-DPAT is attenuated following raphe injection of 5,7-dihydroxytryptamine. Currie, P.J., Coscina, D.V., Fletcher, P.J. Brain Res. (1998) [Pubmed]
The effects of dorsal raphe administration of eltoprazine, TFMPP and 8-OH-DPAT on resident intruder aggression in the rat. Mos, J., Olivier, B., Poth, M., Van Oorschot, R., Van Aken, H. Eur. J. Pharmacol. (1993) [Pubmed]
Development of simultaneous gas chromatography-mass spectrometric and liquid chromatography-electrospray ionization mass spectrometric determination method for the new designer drugs, N-benzylpiperazine (BZP), 1-(3-trifluoromethylphenyl)piperazine (TFMPP) and their main metabolites in urine. Tsutsumi, H., Katagi, M., Miki, A., Shima, N., Kamata, T., Nishikawa, M., Nakajima, K., Tsuchihashi, H. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2005) [Pubmed]
Site-selective serotonin agonists as discriminative stimuli. Glennon, R.A. Psychopharmacology series. (1988) [Pubmed]
Facilitation of 8-OHDPAT-induced forepaw treading of rats by the 5-HT2 agonist DOI. Arnt, J., Hyttel, J. Eur. J. Pharmacol. (1989) [Pubmed]

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