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Chemical Compound Review

8-OH-Dpat     7-(dipropylamino)-5,6,7,8...

Synonyms: CHEMBL56, SureCN496783, AG-J-78902, CHEBI:73364, CCG-204665, ...
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Analytical, diagnostic and therapeutic context of 8-OH-Dpat


  1. The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). A model of presynaptic 5-HT1 function. Goodwin, G.M., De Souza, R.J., Green, A.R. Neuropharmacology (1985) [Pubmed]
  2. Differential effects of the serotonin1A agonist, 8-OH-DPAT, on masculine and feminine sexual behavior of the ferret. Paredes, R.G., Kica, E., Baum, M.J. Psychopharmacology (Berl.) (1994) [Pubmed]
  3. Electrophysiological evidence for postsynaptic 5-HT(1A) receptor control of dorsal raphe 5-HT neurones. Martín-Ruiz, R., Ugedo, L. Neuropharmacology (2001) [Pubmed]
  4. The therapeutic efficacy conferred by the 5-HT(1A) receptor agonist 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) after experimental traumatic brain injury is not mediated by concomitant hypothermia. Kline, A.E., Massucci, J.L., Dixon, C.E., Zafonte, R.D., Bolinger, B.D. J. Neurotrauma (2004) [Pubmed]
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  6. Effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on locomotor activity and rearing of mice and rats. Evenden, J.L., Angeby-Möller, K. Psychopharmacology (Berl.) (1990) [Pubmed]
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  8. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Sørensen, E., Grønli, J., Bjorvatn, B., Ursin, R. Behav. Brain Res. (2001) [Pubmed]
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  17. The effects of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioral sensitization: a microanalysis of locomotor activity. De La Garza, R., Cunningham, K.A. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  18. The effects of adrenalectomy and ovariectomy on the behavioral and hypothermic responses of rats to 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT). Young, A.H., Dow, R.C., Goodwin, G.M., Fink, G. Neuropharmacology (1993) [Pubmed]
  19. Inhibitory effects of the 5-HT1A agonists, 5-hydroxy- and 5-methoxy-(3-di-n-propylamino)chroman, on female lordosis behavior. Uphouse, L., Caldarola-Pastuszka, M., Moore, N. Neuropharmacology (1993) [Pubmed]
  20. Behavioral and biochemical effects of the 5-HT1A receptor agonists flesinoxan and 8-OH-DPAT in the rat. Ahlenius, S., Larsson, K., Wijkström, A. Eur. J. Pharmacol. (1991) [Pubmed]
  21. N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin. Glennon, R.A., Titeler, M., Lyon, R.A., Slusher, R.M. J. Med. Chem. (1988) [Pubmed]
  22. Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. Wikström, H., Elebring, T., Hallnemo, G., Andersson, B., Svensson, K., Carlsson, A., Rollema, H. J. Med. Chem. (1988) [Pubmed]
  23. Hypotensive effects of 8-hydroxy-2-(di-n-propylamino)tetralin and 5-methylurapidil following stereotaxic microinjection into the ventral medulla of the rat. Valenta, B., Singer, E.A. Br. J. Pharmacol. (1990) [Pubmed]
  24. Circadian rhythm in the response of central 5-HT1A receptors to 8-OH-DPAT in rats. Lu, J.Q., Nagayama, H. Psychopharmacology (Berl.) (1996) [Pubmed]
  25. Adaptive changes in 5-HT1A receptor-mediated hippocampal inhibition in the alert rat produced by repeated 8-OH-DPAT treatment. Manahan-Vaughan, D., Anwyl, R., Rowan, M.J. Br. J. Pharmacol. (1994) [Pubmed]
  26. Administration of 8-hydroxy-2-(Di-n-propylamino)tetralin in raphe nuclei dorsalis and medianus reduces serotonin synthesis in the rat brain: differences in potency and regional sensitivity. Invernizzi, R., Carli, M., Di Clemente, A., Samanin, R. J. Neurochem. (1991) [Pubmed]
  27. Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro. Maura, G., Raiteri, M. J. Neurochem. (1996) [Pubmed]
  28. Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain. Casanovas, J.M., Vilaró, M.T., Mengod, G., Artigas, F. J. Neurochem. (1999) [Pubmed]
  29. Dissociable roles for the dorsal and median raphé in the facilitatory effect of 5-HT1A receptor stimulation upon cocaine-induced locomotion and sensitization. Szumlinski, K.K., Frys, K.A., Kalivas, P.W. Neuropsychopharmacology (2004) [Pubmed]
  30. The 5-HT(1A) receptor agonist 8-OH-DPAT prevents prefrontocortical glutamate and serotonin release in response to blockade of cortical NMDA receptors. Calcagno, E., Carli, M., Invernizzi, R.W. J. Neurochem. (2006) [Pubmed]
  31. Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat. Penington, N.J., Kelly, J.S., Fox, A.P. J. Physiol. (Lond.) (1993) [Pubmed]
  32. Reversal of haloperidol-induced extrapyramidal side effects in cebus monkeys by 8-hydroxy-2-(di-n-propylamino)tetralin and its enantiomers. Christoffersen, C.L., Meltzer, L.T. Neuropsychopharmacology (1998) [Pubmed]
  33. (R)-(-)-10-methyl-11-hydroxyaporphine: a highly selective serotonergic agonist. Cannon, J.G., Mohan, P., Bojarski, J., Long, J.P., Bhatnagar, R.K., Leonard, P.A., Flynn, J.R., Chatterjee, T.K. J. Med. Chem. (1988) [Pubmed]
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  35. Paroxetine is effective in desensitizing 5-HT1A receptor function in adult offspring exposed prenatally to cocaine. Chen, Z., Tetzlaff, J., Sripathirathan, K., Carrasco, G.A., Shankaran, M., Van De Kar, L.D., Muma, N.A., Battaglia, G. Psychopharmacology (Berl.) (2005) [Pubmed]
  36. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Heisler, L.K., Chu, H.M., Brennan, T.J., Danao, J.A., Bajwa, P., Parsons, L.H., Tecott, L.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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  41. Central dopaminergic and 5-hydroxytryptaminergic effects of C3-methylated derivatives of 8-hydroxy-2-(di-n-propylamino)tetralin. Mellin, C., Björk, L., Karlén, A., Johansson, A.M., Sundell, S., Kenne, L., Nelson, D.L., Andén, N.E., Hacksell, U. J. Med. Chem. (1988) [Pubmed]
  42. Effects of injections of 8-hydroxy-2-(di-n-propylamino)tetralin or muscimol in the median raphe nucleus on c-fos mRNA in the rat brain. Funk, D., Li, Z., Fletcher, P.J., Lê, A.D. Neuroscience (2005) [Pubmed]
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  44. 8-hydroxy-2-(di-N-propylamino)tetralin increases the activity of adenylate cyclase in the hippocampus of freely-moving rats. Sijbesma, H., Schipper, J., Molewijk, H.E., Bosch, A.I., de Kloet, E.R. Neuropharmacology (1991) [Pubmed]
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