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Chemical Compound Review

N-FORMYLMETHIONINE     (2S)-2-formamido-4- methylsulfanyl-butanoic...

Synonyms: for-met-oh, AG-F-52279, CHEBI:16552, ANW-29889, CTK1D5830, ...
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Disease relevance of N-formyl-L-methionine


High impact information on N-formyl-L-methionine

  • Analysis by partial proteolytic digestion of the P23 family labeled biosynthetically with [35S] methionine, and P23, labeled with [35S] formyl-methionine by in vitro translation of RNA from infected cells, revealed that the proteins of the P23 family differ in their amino-terminal domains [5].
  • Both the standard virus and the defective-interfering virus RNA direct the synthesis of two polypeptides labeled with n-formyl-methionine (fmet) at their amino termini [4].
  • Of interest, peptides containing formyl-methionine are potent chemoattractants for neutrophils, suggesting that delta-toxin deformylation may have functional consequences [6].
  • The transition from producing both species of delta-toxin to producing only formyl-methionine-containing delta-toxin coincided with increased tricarboxylic acid (TCA) cycle activity [6].
  • The low incorporation in comparison to formyl-methionine was not due to the lack of interaction of fluorophore-Met-tRNA(f) with IF-2 [7].

Anatomical context of N-formyl-L-methionine

  • Bovine cornea extracted with 0.154 M NaCl yielded a protein fraction which (i) inhibited protein synthesis in rabbit reticulocyte lysates, and (ii) reduced the incorporation of formyl-methionine from f[35S]Met-tRNA(f) into polypeptides [8].

Associations of N-formyl-L-methionine with other chemical compounds


Analytical, diagnostic and therapeutic context of N-formyl-L-methionine


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  2. Lipopolysaccharide induces formyl peptide receptor 1 gene expression in macrophages and neutrophils via transcriptional and posttranscriptional mechanisms. Mandal, P., Novotny, M., Hamilton, T.A. J. Immunol. (2005) [Pubmed]
  3. Autoantibodies specific for U1 RNA and initiator methionine tRNA. Wilusz, J., Keene, J.D. J. Biol. Chem. (1986) [Pubmed]
  4. Capsid protein precursor is one of two initiated products of translation of poliovirus RNA in vitro. Humphries, S., Knauert, F., Ehrenfeld, E. J. Virol. (1979) [Pubmed]
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  6. Synthesis and deformylation of Staphylococcus aureus delta-toxin are linked to tricarboxylic acid cycle activity. Somerville, G.A., Cockayne, A., Dürr, M., Peschel, A., Otto, M., Musser, J.M. J. Bacteriol. (2003) [Pubmed]
  7. Initiation of protein synthesis with fluorophore-Met-tRNA(f) and the involvement of IF-2. McIntosh, B., Ramachandiran, V., Kramer, G., Hardesty, B. Biochimie (2000) [Pubmed]
  8. Some properties of a partially purified inhibitor of protein synthesis isolated from bovine cornea. Wu, J.M., Herp, A. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  9. The crystal structure of the light-harvesting complex II (B800-850) from Rhodospirillum molischianum. Koepke, J., Hu, X., Muenke, C., Schulten, K., Michel, H. Structure (1996) [Pubmed]
  10. Cloning, sequencing, and characterization of Escherichia coli thioesterase II. Naggert, J., Narasimhan, M.L., DeVeaux, L., Cho, H., Randhawa, Z.I., Cronan, J.E., Green, B.N., Smith, S. J. Biol. Chem. (1991) [Pubmed]
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