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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Activity Cycles

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Disease relevance of Activity Cycles


High impact information on Activity Cycles


Chemical compound and disease context of Activity Cycles


Biological context of Activity Cycles


Anatomical context of Activity Cycles


Associations of Activity Cycles with chemical compounds

  • The (15)N-urea/(15)N-glutamine ratio is a sensitive index of in vivo urea cycle activity and correlates with clinical severity [10].
  • Evolutionary conserved light regulation of Calvin cycle activity by NADPH-mediated reversible phosphoribulokinase/CP12/ glyceraldehyde-3-phosphate dehydrogenase complex dissociation [24].
  • Diphenyleneiodonium (0.1 mmol/L), an inhibitor of superoxide and nitric oxide synthesis inhibited the phorbol 12-myristate 13-acetate-induced increased pentose cycle activity with no effects on the t-butyl hydroperoxide-induced response.(ABSTRACT TRUNCATED AT 250 WORDS)[1]
  • Each neuron's activity was concentrated in a particular phase of the ipsilateral hip flexor muscle nerve (VP-HP) activity cycle; each had a distinct "preferred phase." Each neuron's preferred phase during fictive rostral scratching was similar to its preferred phase during fictive pocket scratching [25].
  • In order to evaluate the metabolic response of nutritionally deprived cancer patients to parenteral nutrition, metabolic parameters including glucose turnover, oxidation, and Cori cycle activity were measured in eight patients before and during short-term (5 to 10 days) i.v. nutrition, with solutions containing amino acids and hypertonic glucose [26].

Gene context of Activity Cycles


Analytical, diagnostic and therapeutic context of Activity Cycles


  1. Augmented glucose use and pentose cycle activity in hepatic endothelial cells after in vivo endotoxemia. Spolarics, Z., Spitzer, J.J. Hepatology (1993) [Pubmed]
  2. Altered glucose metabolism in metastatic carcinoma. Holroyde, C.P., Gabuzda, T.G., Putnam, R.C., Paul, P., Reichard, G.A. Cancer Res. (1975) [Pubmed]
  3. Efficient Salmonella entry requires activity cycles of host ADF and cofilin. Dai, S., Sarmiere, P.D., Wiggan, O., Bamburg, J.R., Zhou, D. Cell. Microbiol. (2004) [Pubmed]
  4. Metabolism of [1-(13)C)glucose and [2-(13)C]acetate in the hypoxic rat brain.. Chateil, J., Biran, M., Thiaudière, E., Canioni, P., Merle, M. Neurochem. Int. (2001) [Pubmed]
  5. Thyroid hormone excess and glucose intolerance. Dimitriadis, G.D., Raptis, S.A. Exp. Clin. Endocrinol. Diabetes (2001) [Pubmed]
  6. The Drosophila dCREB2 gene affects the circadian clock. Belvin, M.P., Zhou, H., Yin, J.C. Neuron (1999) [Pubmed]
  7. Loss of hepatic autoregulation after carbohydrate overfeeding in normal man. Clore, J.N., Helm, S.T., Blackard, W.G. J. Clin. Invest. (1995) [Pubmed]
  8. Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells. Schraufstätter, I.U., Hinshaw, D.B., Hyslop, P.A., Spragg, R.G., Cochrane, C.G. J. Clin. Invest. (1985) [Pubmed]
  9. Mitotic phosphorylation of rab4 prevents binding to a specific receptor on endosome membranes. Ayad, N., Hull, M., Mellman, I. EMBO J. (1997) [Pubmed]
  10. In vivo urea cycle flux distinguishes and correlates with phenotypic severity in disorders of the urea cycle. Lee, B., Yu, H., Jahoor, F., O'Brien, W., Beaudet, A.L., Reeds, P. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  11. Bioreductive metabolism of SR-4233 (WIN 59075) by whole cell suspensions under aerobic and hypoxic conditions: role of the pentose cycle and implications for the mechanism of cytotoxicity observed in air. Tuttle, S.W., Hazard, L., Koch, C.J., Mitchell, J.B., Coleman, C.N., Biaglow, J.E. Int. J. Radiat. Oncol. Biol. Phys. (1994) [Pubmed]
  12. Pyruvate alleviates toxic effects of ethanol on cells in culture. Fukaya, K., Miyazaki, M., Pu, H., Katayama, B., Inoue, Y., Ohashi, R., Nakamura, C., Namba, M. Arch. Toxicol. (1997) [Pubmed]
  13. Glucose metabolism, energetics, and function of rat hearts exposed to ischemic preconditioning and oxygenated cardioplegia. Olivson, A., Berman, E., Houminer, E., Borman, J.B., Merin, G., Karck, M., Haverich, A., Chisin, R., Schwalb, H. Journal of cardiac surgery. (2002) [Pubmed]
  14. Response of phosphoenolpyruvate cycle activity to fasting and to hyperinsulinemia in human subjects. Wolfe, R.R., Chinkes, D., Baba, H., Rosenblatt, J., Zhang, X.J. Am. J. Physiol. (1996) [Pubmed]
  15. Effects of chronic jet lag on tumor progression in mice. Filipski, E., Delaunay, F., King, V.M., Wu, M.W., Claustrat, B., Gréchez-Cassiau, A., Guettier, C., Hastings, M.H., Francis, L. Cancer Res. (2004) [Pubmed]
  16. Modulation of Xenopus embryo mesoderm-specific gene expression and dorsoanterior patterning by receptors that activate the phosphatidylinositol cycle signal transduction pathway. Ault, K.T., Durmowicz, G., Galione, A., Harger, P.L., Busa, W.B. Development (1996) [Pubmed]
  17. The effect of cortisol on glucose/glucose-6-phosphate cycle activity and insulin action. Rooney, D.P., Neely, R.D., Cullen, C., Ennis, C.N., Sheridan, B., Atkinson, A.B., Trimble, E.R., Bell, P.M. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  18. The measurement of bioreductive capacity of tumor cells using methylene blue. Biaglow, J.E., Koch, C.J., Tuttle, S.W., Manevich, Y., Ayene, I.S., Bernhard, E.J., McKenna, W.G., Kachur, A.V. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  19. 6-Phosphogluconate/glucose-6-phosphate ratio in rat pancreatic islets during inhibition of insulin release by exogenous insulin. Akhtar, M.S., Verspohl, E., Hegner, D., Ammon, H.P. Diabetes (1977) [Pubmed]
  20. A comparison of 13C nuclear magnetic resonance and 14C tracer studies of hepatic metabolism. Cohen, S.M., Rognstad, R., Shulman, R.G., Katz, J. J. Biol. Chem. (1981) [Pubmed]
  21. Uterus of the rat during early progestation: pyridine nucleotide activity and its relation to preimplantation changes in pentose cycle activity. Mallonee, R.C., Yochim, J.M. Biol. Reprod. (1980) [Pubmed]
  22. Sensitivity to chemical oxidants and radiation in CHO cell lines deficient in oxidative pentose cycle activity. Tuttle, S.W., Varnes, M.E., Mitchell, J.B., Biaglow, J.E. Int. J. Radiat. Oncol. Biol. Phys. (1992) [Pubmed]
  23. Leukotriene B4 stimulation of phosphatidylinositol turnover in macrophages and inhibition by pertussis toxin. Holian, A. FEBS Lett. (1986) [Pubmed]
  24. Evolutionary conserved light regulation of Calvin cycle activity by NADPH-mediated reversible phosphoribulokinase/CP12/ glyceraldehyde-3-phosphate dehydrogenase complex dissociation. Wedel, N., Soll, J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  25. Activity of descending propriospinal axons in the turtle hindlimb enlargement during two forms of fictive scratching: phase analyses. Berkowitz, A., Stein, P.S. J. Neurosci. (1994) [Pubmed]
  26. Metabolic response to total parenteral nutrition in cancer patients. Holroyde, C.P., Myers, R.N., Smink, R.D., Putnam, R.C., Paul, P., Reichard, G.A. Cancer Res. (1977) [Pubmed]
  27. Endothelin-stimulated Ca2+ mobilization by 3T3-L1 adipocytes is suppressed by tumor necrosis factor-alpha. Yorek, M., Jaipaul, N., Dunlap, J., Bielefeldt, K. Arch. Biochem. Biophys. (1999) [Pubmed]
  28. The life cycle of the steroidogenic acute regulatory (StAR) protein: from transcription through proteolysis. Granot, Z., Silverman, E., Friedlander, R., Melamed-Book, N., Eimerl, S., Timberg, R., Hales, K.H., Hales, D.B., Stocco, D.M., Orly, J. Endocr. Res. (2002) [Pubmed]
  29. CP12 provides a new mode of light regulation of Calvin cycle activity in higher plants. Wedel, N., Soll, J., Paap, B.K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  30. Interleukin-1 beta reduces daily activity level in male lizards, Sceloporus occidentalis. Dunlap, K.D., Church, D.R. Brain Behav. Immun. (1996) [Pubmed]
  31. Pentose cycle activity of the isolated perfused rat lung. Bassett, D.J., Fisher, A.B. Am. J. Physiol. (1976) [Pubmed]
  32. Inhibition of pentose cycle of A549 cells by 6-aminonicotinamide: consequences for aerobic and hypoxic radiation response and for radiosensitizer action. Varnes, M.E. NCI monographs : a publication of the National Cancer Institute. (1988) [Pubmed]
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