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Chemical Compound Review

Lopac-P-9159     piperidine-4-sulfonic acid

Synonyms: CHEMBL34155, P9159_SIGMA, CHEBI:146429, CCG-205104, Lopac0_001024, ...
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Disease relevance of piperidine-4-sulfonic acid


High impact information on piperidine-4-sulfonic acid


Anatomical context of piperidine-4-sulfonic acid

  • When administered microelectrophoretically, GABA and the GABA-mimetic piperidine-4-sulphonic acid (P4S) appear to have no direct hyperpolarizing or depolarizing effect on the terminations of motor axon collaterals excited electrically in the ventral horn of the lumbar spinal cord of the cat [7].


  1. The central medial nucleus: thalamic site of seizure regulation. Miller, J.W., Ferrendelli, J.A. Brain Res. (1990) [Pubmed]
  2. Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Wafford, K.A., Thompson, S.A., Thomas, D., Sikela, J., Wilcox, A.S., Whiting, P.J. Mol. Pharmacol. (1996) [Pubmed]
  3. Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations. Ebert, B., Wafford, K.A., Whiting, P.J., Krogsgaard-Larsen, P., Kemp, J.A. Mol. Pharmacol. (1994) [Pubmed]
  4. Brain-stem areas tonically inhibiting dorsal horn neurones: studies with microinjection of the GABA analogue piperidine-4-sulphonic acid. Foong, F.W., Duggan, A.W. Pain (1986) [Pubmed]
  5. Characterization of the binding of the GABA agonist [3H]piperidine-4-sulphonic acid to bovine brain synaptic membranes. Krogsgaard-Larsen, P., Snowman, A., Lummis, S.C., Olsen, R.W. J. Neurochem. (1981) [Pubmed]
  6. Role of the fastigial nucleus in generalized seizures as demonstrated by GABA agonist microinjections. Miller, J.W., Gray, B.C., Turner, G.M. Epilepsia (1993) [Pubmed]
  7. On the probable absence of GABA receptors on the terminations of motor axon collaterals in the cat spinal cord. Curtis, D.R., Gynther, B.D. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1986) [Pubmed]
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