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Chemical Compound Review

Avobenzona     1-(4-methoxyphenyl)-3-(4- tert...

Synonyms: Avobenzone, Avobenzonum, Escalol 517, Eusolex 9020, SureCN15650, ...
 
 
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Disease relevance of Photoplex

 

High impact information on Photoplex

  • Parsol 1789 (100 microM) caused a 2-fold increase in protein carbonyl formation (an index of oxidative damage) in bovine serum albumin (BSA) when exposed to illumination, and this damage was both concentration- and time-dependent [3].
  • We compare indolinonic nitroxides and the piperidines TEMPO and TEMPOL for their ability to inhibit strand breaks inflicted on DNA when it is illuminated in vitro in the presence of dibenzoylmethane (DBM) and a relative, Parsol 1789, used as a UVA-absorbing sunscreen [4].
  • It seems that (a) triplet-state energy transfer from avobenzone to DESM and (b) scavenging of reactive species are responsible for the observed stabilization of avobenzone [5].
  • Butyl methoxydibenzoylmethane (B-MDM) only showed weak ERalpha agonism and weak AR antagonism [6].
  • Films of a commercial sunscreen product containing avobenzone, oxybenzone and octinoxate were irradiated using a fluorescent UV-A phototherapy lamp with additional UV-B blocking filter [7].
 

Biological context of Photoplex

 

Anatomical context of Photoplex

 

Associations of Photoplex with other chemical compounds

References

  1. Photocontact dermatitis due to isopropyl and butyl methoxy dibenzoylmethanes (Eusolex 8020 and Parsol 1789). Motley, R.J., Reynolds, A.J. Contact Derm. (1989) [Pubmed]
  2. Photoallergic contact dermatitis due to combined UVB (4-methylbenzylidene camphor/octyl methoxycinnamate) and UVA (benzophenone-3/butyl methoxydibenzoylmethane) absorber sensitization. Schmidt, T., Ring, J., Abeck, D. Dermatology (Basel) (1998) [Pubmed]
  3. Increased oxidative modification of albumin when illuminated in vitro in the presence of a common sunscreen ingredient: protection by nitroxide radicals. Damiani, E., Carloni, P., Biondi, C., Greci, L. Free Radic. Biol. Med. (2000) [Pubmed]
  4. Nitroxide radicals protect DNA from damage when illuminated in vitro in the presence of dibenzoylmethane and a common sunscreen ingredient. Damiani, E., Greci, L., Parsons, R., Knowland, J. Free Radic. Biol. Med. (1999) [Pubmed]
  5. Design of a photostabilizer having built-in antioxidant functionality and its utility in obtaining broad-spectrum sunscreen formulations. Chaudhuri, R.K., Lascu, Z., Puccetti, G., Deshpande, A.A., Paknikar, S.K. Photochem. Photobiol. (2006) [Pubmed]
  6. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Schreurs, R.H., Sonneveld, E., Jansen, J.H., Seinen, W., van der Burg, B. Toxicol. Sci. (2005) [Pubmed]
  7. Unexpected photolysis of the sunscreen octinoxate in the presence of the sunscreen avobenzone. Sayre, R.M., Dowdy, J.C., Gerwig, A.J., Shields, W.J., Lloyd, R.V. Photochem. Photobiol. (2005) [Pubmed]
  8. Photomutagenesis test development: II. 8-Methoxypsoralen, chlorpromazine and sunscreen compounds in chromosomal aberration assays using CHO cells. Chételat, A., Dresp, J.H., Gocke, E. Mutat. Res. (1993) [Pubmed]
  9. Influence of cyclodextrins on in vitro human skin absorption of the sunscreen, butyl-methoxydibenzoylmethane. Simeoni, S., Scalia, S., Benson, H.A. International journal of pharmaceutics. (2004) [Pubmed]
  10. Lack of in vitro protection by a common sunscreen ingredient on UVA-induced cytotoxicity in keratinocytes. Armeni, T., Damiani, E., Battino, M., Greci, L., Principato, G. Toxicology (2004) [Pubmed]
  11. Indoor and outdoor efficacy testing of a broad-spectrum sunscreen against ultraviolet A radiation in psoralen-sensitized subjects. Lowe, N.J., Dromgoole, S.H., Sefton, J., Bourget, T., Weingarten, D. J. Am. Acad. Dermatol. (1987) [Pubmed]
  12. Occurrence of UV filter compounds from sunscreens in surface waters: regional mass balance in two Swiss lakes. Poiger, T., Buser, H.R., Balmer, M.E., Bergqvist, P.A., Müller, M.D. Chemosphere (2004) [Pubmed]
 
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