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Chemical Compound Review:

Padimatum pentyl 4-dimethylaminobenzoate

Synonyms: Padimate A, Padimate (INN), SureCN15372, CHEMBL2107071, AC-15263, ...

Ho, K.K. et al., Morgan, T.M. et al., Hayden, C.G. et al., Bestak, R. et al., Chen, C.T. et al., et al.

Chen, Kuo, Ku, Weng, Liu,

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Disease relevance of Pentyl dimethyl PABA

In contrast to the effects on LC, Padimate O, but not 2-EHMC, protected Thy-1+ dEC from UV exposure in both mouse strains, but neither protected against the development of local immunosuppression using a contact sensitivity model [1].
Phototoxicity to a sunscreen ingredient. Padimate A [2].

High impact information on Pentyl dimethyl PABA

Using a UV protocol that induced local but not systemic immunosuppression or tolerance in BALB/c mice, it was shown that Padimate O made the immunosuppression worse, whereas 2-EHMC and MTD protected the immune system [3].
This study compares the ability of two commonly used sunscreens--octyl dimethyl para-aminobenzoate (Padimate O) and 2-ethylhexyl-p-methoxycinnamate (2-EHMC)--to protect Langerhans cells (LC), Thy-1+ dendritic epidermal cells (Thy-1+ dEC), and local contact sensitivity (CS) from the effects of ultraviolet (UV) light [1].
Representative examples of commercial interests such as Padimate O and antioxidant additives for plastics were also examined to demonstrate their practical applications [4].
Enhanced buccal mucosal retention and reduced buccal permeability of estradiol in the presence of padimate O and Azone: a mechanistic study [5].
This study investigated the enhanced transdermal delivery of testosterone (Tes) and estradiol (E2) in swine in vivo with novel metered-dose topical aerosols containing the penetration enhancer padimate O (PadO) and predicted the dose deliverable in humans from the calculated drug flux across the skin [6].

Anatomical context of Pentyl dimethyl PABA

The penetration and retention of five commonly used sunscreen agents (avobenzone, octinoxate, octocrylene, oxybenzone and padimate O) in human skin was evaluated after application in mineral oil to isolated human epidermal membranes [7].

References

Sunscreens protect epidermal Langerhans cells and Thy-1+ cells but not local contact sensitization from the effects of ultraviolet light. Ho, K.K., Halliday, G.M., Barnetson, R.S. J. Invest. Dermatol. (1992) [Pubmed]
Phototoxicity to a sunscreen ingredient. Padimate A. Kaidbey, K.H., Kligman, A.M. Archives of dermatology. (1978) [Pubmed]
Sunscreen protection of contact hypersensitivity responses from chronic solar-simulated ultraviolet irradiation correlates with the absorption spectrum of the sunscreen. Bestak, R., Barnetson, R.S., Nearn, M.R., Halliday, G.M. J. Invest. Dermatol. (1995) [Pubmed]
Nucleophilic acyl substitutions of esters with protic nucleophiles mediated by amphoteric, oxotitanium, and vanadyl species. Chen, C.T., Kuo, J.H., Ku, C.H., Weng, S.S., Liu, C.Y. J. Org. Chem. (2005) [Pubmed]
Enhanced buccal mucosal retention and reduced buccal permeability of estradiol in the presence of padimate O and Azone: a mechanistic study. Nicolazzo, J.A., Reed, B.L., Finnin, B.C. Journal of pharmaceutical sciences. (2005) [Pubmed]
Enhanced transdermal delivery of sex hormones in swine with a novel topical aerosol. Morgan, T.M., Parr, R.A., Reed, B.L., Finnin, B.C. Journal of pharmaceutical sciences. (1998) [Pubmed]
Sunscreen penetration of human skin and related keratinocyte toxicity after topical application. Hayden, C.G., Cross, S.E., Anderson, C., Saunders, N.A., Roberts, M.S. Skin pharmacology and physiology. (2005) [Pubmed]

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