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Chemical Compound Review

library 2     ethylN-[2-(benzyl-phenethyl- amino)-8-(2,4...

Synonyms: AC1NRPM1, SureCN13327444
 
 
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Disease relevance of library 2

  • The advantages of a high-throughput functional screening system based on the HVJ-E vector include (1) rapid preparation of the vector containing the DNA library, (2) effective fusion-mediated transfer of the plasmids to various cells with minimal toxicity, and (3) easy cloning of candidate genes by transformation of Escherichia coli [1].
  • From this library, 2 fragments were chosen and pooled to probe isolates of S typhimurium obtained during an episode of salmonellosis in a veterinary medical teaching hospital [2].
  • Using universal primers, a 518 bp subtilisin-like serine protease gene fragment was amplified from P. marinus genomic DNA and used as a probe to screen a lambda-phage P. marinus genomic library; 2 different lambda-phage clones hybridized to the digoxigenin(DIG)-labeled subtilisin-like gene fragment [3].
 

Psychiatry related information on library 2

  • The Cool-2 (cloned-out of library-2) protein (identical to alpha-Pix for Pak-interactive exchange factor) has been implicated in various biological responses including chemoattractant signaling and in certain forms of mental retardation [4].
 

High impact information on library 2

  • From this library, 2 clones, L7 and L19, were isolated by a differential hybridization procedure and shown by in situ hybridization to be Purkinje cell-specific within the cerebellum [5].
  • GENAS enables us to retrieve any sequence data from EMBL nucleotide sequence data library (2) and readily to analyze them (if necessary, together with private data) by various application programs in a interactive manner [6].
  • Three cDNAs encoding the precursor proteins of porcine UII were cloned from a porcine spinal cord cDNA library; 2 consist of 121 amino acid residues and the other, which seemed to be a splicing variant, consist of 85 residues [7].
  • Comparison of the gene expression profiles between the stage 1-3 and stage 2-3 egg chamber libraries revealed that 272 tags were significantly more abundant in stage 1-3 egg chambers (p<0.05 and at least two-fold change) than in library 2 [8].

References

  1. Development of high-throughput functional screening of therapeutic genes, using a hemagglutinating virus of Japan envelope vector. Nishikawa, T., Nakagami, H., Matsuki, A., Maeda, A., Yo, C.Y., Harada, T., Morishita, R., Tamai, K., Kaneda, Y. Hum. Gene Ther. (2006) [Pubmed]
  2. Use of random fragments of chromosomal DNA to highlight restriction site heterogeneity for fingerprinting isolates of Salmonella typhimurium from hospitalized animals. Hansen, L.M., Jang, S.S., Hirsh, D.C. Am. J. Vet. Res. (1993) [Pubmed]
  3. Isolation and characterization of serine protease gene(s) from Perkinsus marinus. Brown, G.D., Reece, K.S. Dis. Aquat. Org. (2003) [Pubmed]
  4. Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. Feng, Q., Baird, D., Cerione, R.A. EMBO J. (2004) [Pubmed]
  5. A Purkinje cell differentiation marker shows a partial DNA sequence homology to the cellular sis/PDGF2 gene. Oberdick, J., Levinthal, F., Levinthal, C. Neuron (1988) [Pubmed]
  6. GENAS: a database system for nucleic acid sequence analysis. Kuhara, S., Matsuo, F., Futamura, S., Fujita, A., Shinohara, T., Takagi, T., Sakaki, Y. Nucleic Acids Res. (1984) [Pubmed]
  7. Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14). Mori, M., Sugo, T., Abe, M., Shimomura, Y., Kurihara, M., Kitada, C., Kikuchi, K., Shintani, Y., Kurokawa, T., Onda, H., Nishimura, O., Fujino, M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  8. SAGE analysis of early oogenesis in the silkworm, Bombyx mori. Funaguma, S., Hashimoto, S., Suzuki, Y., Omuro, N., Sugano, S., Mita, K., Katsuma, S., Shimada, T. Insect Biochem. Mol. Biol. (2007) [Pubmed]
 
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