Gene Review:
ARHGEF6 - Rac/Cdc42 guanine nucleotide exchange...
Homo sapiens
Synonyms:
Alpha-Pix, COOL-2, COOL2, Cool-2, Cool2, ...
- Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. Kutsche, K., Yntema, H., Brandt, A., Jantke, I., Nothwang, H.G., Orth, U., Boavida, M.G., David, D., Chelly, J., Fryns, J.P., Moraine, C., Ropers, H.H., Hamel, B.C., van Bokhoven, H., Gal, A. Nat. Genet. (2000)
- Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. Feng, Q., Baird, D., Cerione, R.A. EMBO J. (2004)
- Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin. Yokota, T., Kouno, J., Adachi, K., Takahashi, H., Teramoto, A., Matsumoto, K., Sugisaki, Y., Onda, M., Tsunoda, T. Acta Neuropathol. (2006)
- Genomic structure of human alpha-pix, and variable deletions in a poly (T) tract in gastric cancer tissue. Wang, Y.J., Oba, S.M., Yoshii, S., Song, J.P., Wang, Y., Kanamori, M., Ota, S., Tanaka, M., Sugimura, H. Cancer Lett. (2001)
- Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. Rosenberger, G., Jantke, I., Gal, A., Kutsche, K. Hum. Mol. Genet. (2003)
- Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis. Nod??-Langlois, R., Muller, D., Boda, B. J. Cell. Sci. (2006)
- Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene. Yoshii, S., Tanaka, M., Otsuki, Y., Fujiyama, T., Kataoka, H., Arai, H., Hanai, H., Sugimura, H. Mol. Cell. Biol. (2001)
- The mouse Arhgef6 gene: cDNA sequence, expression analysis, and chromosome assignment. Kutsche, K., Gal, A. Cytogenet. Cell Genet. (2001)
- The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade. Baird, D., Feng, Q., Cerione, R.A. Curr. Biol. (2005)
- Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. Filipenko, N.R., Attwell, S., Roskelley, C., Dedhar, S. Oncogene (2005)
- PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation. Gringel, A., Walz, D., Rosenberger, G., Minden, A., Kutsche, K., Kopp, P., Linder, S. J. Cell. Physiol. (2006)
- AlphaPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Rosenberger, G., Gal, A., Kutsche, K. J. Biol. Chem. (2005)
- Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. Feng, Q., Albeck, J.G., Cerione, R.A., Yang, W. J. Biol. Chem. (2002)
- Characterization of ARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: mutation screening in Börjeson-Forssman-Lehmann syndrome and MRX27. Lower, K.M., Gecz, J. Am. J. Med. Genet. (2001)