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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Torleva     (2S)-2-(2-oxopyrrolidin-1- yl)butanamide

Synonyms: Keppra, Levetiractam, Levetiracetam, Levetriacetam, Leviteracetam, ...
 
 
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Disease relevance of Levetiracetam

  • LEV (25, 50, and 100 mg/kg, p.o.) had no effects on afterdischarge induction and slightly decreased afterdischarge duration, whereas it markedly decreased seizure stage and motor seizure duration [1].
 

Psychiatry related information on Levetiracetam

 

High impact information on Levetiracetam

  • RESULTS: More than 40% of subjects in clinical trials of tiagabine (TGB), topiramate (TPM), and levetiracetam (LEV) experienced an increase in seizures while taking a placebo [3].
  • GBP, LTG, TGB, and LEV, at low concentrations, do not significantly change the metabolic activities examined and do not demonstrate toxic actions on astrocytes [4].
  • This study reports the solubilization of the rat synaptic vesicle protein SV2A, the brain binding site for the antiepileptic drug levetiracetam (LEV), and its characterization [5].
  • Competition binding experiments with a variety of LEV analogues indicated that [3H]ucb 30889 labels the same binding site in both crude homogenates and soluble extracts, with still high stereoselectivity [5].
 

Gene context of Levetiracetam

  • N-dodecyl-beta-D-maltoside (DDM) was the best detergent at achieving a high percentage of SV2A solubilization and at maintaining the binding characteristics of a tritiated form of a more potent analogue of LEV, [3H]ucb 30889 ((2S)-2-[4-(3-azidophenyl)-2-oxopyrrolidin-1-yl]butanamide) [5].

References

  1. Effects of Nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats. Kitano, Y., Komiyama, C., Makino, M., Kasai, Y., Takasuna, K., Kinoshita, M., Yamazaki, O., Takazawa, A., Yamauchi, T., Sakurada, S. Epilepsia (2005) [Pubmed]
  2. Long-term retention rates of new antiepileptic drugs in adults with chronic epilepsy and learning disability. Simister, R.J., Sander, J.W., Koepp, M.J. Epilepsy & behavior : E&B (2007) [Pubmed]
  3. Aggravation of partial seizures by antiepileptic drugs: is there evidence from clinical trials? Somerville, E.R. Neurology (2002) [Pubmed]
  4. An in vitro study of new antiepileptic drugs and astrocytes. Pavone, A., Cardile, V. Epilepsia (2003) [Pubmed]
  5. Solubilization and immunopurification of rat brain synaptic vesicle protein 2A with maintained binding properties. Lambeng, N., Grossmann, M., Chatelain, P., Fuks, B. Neurosci. Lett. (2006) [Pubmed]
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