Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

leukotriene B5 (6E,8E,10E,14E,17E)-5,12- dihydroxyicosa-6...

Synonyms: LTB 5, L9024_SIGMA, AC1NSO0T, AR-1G5776, PDSP1_000703, ...

Lee, T.H. et al., Wachtler, P. et al., Terano, T. et al., Mehta, J.L. et al., Kragballe, K. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of leukotriene B5

A low-fat diet supplemented with dietary fish oil (Max-EPA) results in improvement of psoriasis and in formation of leukotriene B5 [1].

High impact information on leukotriene B5

Neutrophil leukotriene B4 formation decreased 23 percent (p less than or equal to 0.01) and synthesis of leukotriene B5 became apparent in all subjects [2].
Leukotriene B4 and leukotriene B5 have binding sites on lung membranes and cause contraction of bullfrog lung [3].
RESULTS: Leukocytes from patients of the omega-3 fatty acids group generated significantly higher amounts of less biologically active leukotriene B5 as compared to the control group (p < or = 0.001) [4].

Biological context of leukotriene B5

Characterization of leukotriene B3: comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils [5].

Associations of leukotriene B5 with other chemical compounds

Recently, we reported that leukotriene B5 (LTB5) was at least 30 times less potent than LTB4 in causing aggregation, chemokinesis and degranulation of polymorphonuclear leukocytes in vitro [6].

References

A low-fat diet supplemented with dietary fish oil (Max-EPA) results in improvement of psoriasis and in formation of leukotriene B5. Kragballe, K., Fogh, K. Acta Derm. Venereol. (1989) [Pubmed]
Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease. Effects on indices of platelet and neutrophil function and exercise performance. Mehta, J.L., Lopez, L.M., Lawson, D., Wargovich, T.J., Williams, L.L. Am. J. Med. (1988) [Pubmed]
Leukotriene B4 and leukotriene B5 have binding sites on lung membranes and cause contraction of bullfrog lung. Andazola, J.J., Underwood, J.A., Chiono, M., Torres, O.A., Herman, C.A. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
Influence of a total parenteral nutrition enriched with omega-3 fatty acids on leukotriene synthesis of peripheral leukocytes and systemic cytokine levels in patients with major surgery. Wachtler, P., König, W., Senkal, M., Kemen, M., Köller, M. The Journal of trauma. (1997) [Pubmed]
Characterization of leukotriene B3: comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils. Lee, T.H., Sethi, T., Crea, A.E., Peters, W., Arm, J.P., Horton, C.E., Walport, M.J., Spur, B.W. Clin. Sci. (1988) [Pubmed]
Effect of orally administered eicosapentaenoic acid (EPA) on the formation of leukotriene B4 and leukotriene B5 by rat leukocytes. Terano, T., Salmon, J.A., Moncada, S. Biochem. Pharmacol. (1984) [Pubmed]

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