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Chemical Compound Review

NSC-9     N-[(Z)-3-nitrosobut-2-en-2- yl]hydroxylamine

Synonyms: NSC9, NSC 9, LS-45878, STL283949, AKOS005208866, ...
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Disease relevance of AI3-14925


Psychiatry related information on AI3-14925

  • Based on the dimethylglyoxime (DMG) reaction used for nickel analysis, the sample, as contained in a pH 9.0 buffer, is, after on-line merging with the chelating reagent, transported to a reaction coil attached to one of the external ports of the LOV to assure sufficient reaction time for the formation of Ni(DMG)(2) chelate [2].

High impact information on AI3-14925

  • Determinations of silver(I) (0.05-0.5 ppm) and nickel(II) (1.8-5.0 ppm) follow established C-SPE methods on reversed-phase extraction membranes using 5-(p-dimethylaminobenzylidene)rhodanine and dimethylglyoxime, respectively, as colorimetric reagents [3].
  • Furthermore, the Ni in the CO(L)-deficient CODH can be removed by treatment with a Ni-specific chelator, dimethylglyoxime [4].
  • The protonation state of the dimethylglyoxime ligands in the B(12) coenzyme biomimetic [Co(CCl=CHCl)(dmgH)(2)(py)].CHCl(3) was investigated by using first-principles molecular dynamics [5].
  • This reconciles the results of the experimental determination (Jones, P. G.; Yang, L.; Steinborn, D. Acta Cryst. 1996, C52, 2399), showing all N-O distances as equivalent, with the commonly accepted rule that the protonation state of the dimethylglyoxime ligands can be identified by the different N-O distances [5].
  • X-ray structure determination of the dimethylformamide bis-solvate [PtCl4(NH=C(Me)ON=C(Me)C(Me)=NOH)2] x 2DMF (la) disclosed its overall trans geometry with the dimethylglyoxime part in anti configuration and the amidine one-end (rather than N,N-bidentate) coordination mode of the N-donor ligands [6].

Anatomical context of AI3-14925

  • The CON content was measured spectrophotometrically by the dimethylglyoxime reaction following nitric acid:perchloric acid: sulfuric acid (3:1:1) digestion of blood, urine, and feces samples at 2, 4, 8, and 16 days after the crude oil application [7].

Gene context of AI3-14925

  • Simultaneous detection of nickel and cobalt in the low microg L(-1) range was successfully performed by use of adsorptive cathodic stripping voltammetry (AdCSV) of dimethylglyoxime complexes on a silver-bismuth alloy electrode, and a good correlation was found with corresponding AAS results (r(2)=0.999 for nickel and 0.965 for cobalt) [8].

Analytical, diagnostic and therapeutic context of AI3-14925


  1. Denmark: the dimethylglyoxime test and international nickel dermatitis. Fisher, A.A. Cutis; cutaneous medicine for the practitioner. (1990) [Pubmed]
  2. Highly selective micro-sequential injection lab-on-valve (muSI-LOV) method for the determination of ultra-trace concentrations of nickel in saline matrices using detection by electrothermal atomic absorption spectrometry. Long, X., Miró, M., Jensen, R., Hansen, E.H. Analytical and bioanalytical chemistry. (2006) [Pubmed]
  3. Multiplexed colorimetric solid-phase extraction: determination of silver(I), nickel(II), and sample Ph. Gazda, D.B., Fritz, J.S., Porter, M.D. Anal. Chem. (2004) [Pubmed]
  4. Evidence for a ligand CO that is required for catalytic activity of CO dehydrogenase from Rhodospirillum rubrum. Heo, J., Staples, C.R., Halbleib, C.M., Ludden, P.W. Biochemistry (2000) [Pubmed]
  5. Protonation state of the equatorial ligands and dynamics of the OH...O units in a cobaloxime biomimetic. Rovira, C., Kunc, K., Parrinello, M. Inorganic chemistry. (2002) [Pubmed]
  6. Iminoacylation. 3. Formation of platinum(IV)-based metallaligands due to facile one-end addition of vic-dioximes to coordinated organonitriles. Kukushkin, V.Y., Pakhomova, T.B., Bokach, N.A., Wagner, G., Kuznetsov, M.L., Galanski, M., Pombeiro, A.J. Inorganic chemistry. (2000) [Pubmed]
  7. Urinary excretion of nickel after dermal application of Nigerian light crude oil. Oruambo, I.F. J. Environ. Pathol. Toxicol. Oncol. (2004) [Pubmed]
  8. Evaluations of solid electrodes for use in voltammetric monitoring of heavy metals in samples from metallurgical nickel industry. Mikkelsen, Ø., Skogvold, S.M., Schrøder, K.H., Gjerde, M.I., Aarhaug, T.A. Analytical and bioanalytical chemistry. (2003) [Pubmed]
  9. Nickel release from nickel-plated metals and stainless steels. Haudrechy, P., Foussereau, J., Mantout, B., Baroux, B. Contact Derm. (1994) [Pubmed]
  10. Nickel allergy: analysis of metal clothing objects and patch testing to metal samples. Cavelier, C., Foussereau, J., Massin, M. Contact Derm. (1985) [Pubmed]
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