Chemical Compound Review:
Hemiasterlin (E,4S)-4-[[(2S)-3,3-dimethyl- 2-[[(2S)-3...
Synonyms:
Milnamide B, SureCN57313, CHEMBL185151, NSC-695242, NSC695242, ...
Zask,
Birnberg,
Cheung,
Kaplan,
Niu,
Norton,
Yamashita,
Beyer,
Krishnamurthy,
Greenberger,
Loganzo,
Ayral-Kaloustian,
Zask,
Kaplan,
Musto,
Loganzo,
Nunes,
Kaplan,
Wooters,
Hari,
Minnick,
May,
Shi,
Musto,
Beyer,
Krishnamurthy,
Qiu,
Loganzo,
Ayral-Kaloustian,
Zask,
Greenberger,
Poruchynsky,
Kim,
Nogales,
Annable,
Loganzo,
Greenberger,
Sackett,
Fojo,
Loganzo,
Discafani,
Annable,
Beyer,
Musto,
Hari,
Tan,
Hardy,
Hernandez,
Baxter,
Singanallore,
Khafizova,
Poruchynsky,
Fojo,
Nieman,
Ayral-Kaloustian,
Zask,
Andersen,
Greenberger,
Ravi,
Zask,
Rush,
Boukari,
Nossal,
Sackett,
- Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability. Poruchynsky, M.S., Kim, J.H., Nogales, E., Annable, T., Loganzo, F., Greenberger, L.M., Sackett, D.L., Fojo, T. Biochemistry (2004)
- A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance. Zubovych, I., Doundoulakis, T., Harran, P.G., Roth, M.G. Proc. Natl. Acad. Sci. U.S.A. (2006)
- HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Loganzo, F., Discafani, C.M., Annable, T., Beyer, C., Musto, S., Hari, M., Tan, X., Hardy, C., Hernandez, R., Baxter, M., Singanallore, T., Khafizova, G., Poruchynsky, M.S., Fojo, T., Nieman, J.A., Ayral-Kaloustian, S., Zask, A., Andersen, R.J., Greenberger, L.M. Cancer Res. (2003)
- Two photoaffinity analogues of the tripeptide, hemiasterlin, exclusively label alpha-tubulin. Nunes, M., Kaplan, J., Wooters, J., Hari, M., Minnick, A.A., May, M.K., Shi, C., Musto, S., Beyer, C., Krishnamurthy, G., Qiu, Y., Loganzo, F., Ayral-Kaloustian, S., Zask, A., Greenberger, L.M. Biochemistry (2005)
- Structure-based identification of the binding site for the hemiasterlin analogue HTI-286 on tubulin. Ravi, M., Zask, A., Rush, T.S. Biochemistry (2005)
- Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin. Vashist, Y.K., Tiffon, C., Stoupis, C., Redaelli, C.A. World J. Gastroenterol. (2006)
- D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors. Zask, A., Birnberg, G., Cheung, K., Kaplan, J., Niu, C., Norton, E., Yamashita, A., Beyer, C., Krishnamurthy, G., Greenberger, L.M., Loganzo, F., Ayral-Kaloustian, S. Bioorg. Med. Chem. Lett. (2004)
- Stability of drug-induced tubulin rings by fluorescence correlation spectroscopy. Boukari, H., Nossal, R., Sackett, D.L. Biochemistry (2003)
- Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1. Bai, R., Durso, N.A., Sackett, D.L., Hamel, E. Biochemistry (1999)
- Mapping the bound conformation and protein interactions of microtubule destabilizing peptides by STD-NMR spectroscopy. Milton, M.J., Thomas Williamson, R., Koehn, F.E. Bioorg. Med. Chem. Lett. (2006)
- Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents. Zask, A., Kaplan, J., Musto, S., Loganzo, F. J. Am. Chem. Soc. (2005)