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Chemical Compound Review

CHEMBL2062158     tert-butylN-[(2S,3S,5S)-3- hydroxy-5-[[(1R...

Synonyms: SureCN6366451, AC1L22E5, L-689502, L-689,502, L 689502, ...
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Disease relevance of L 689502


High impact information on L 689502


Chemical compound and disease context of L 689502


Anatomical context of L 689502

  • Histological examination of perfusion-fixed livers 30 min after L-689,502 administration revealed periportal changes including hepatocyte vacuolation and occasional single cell necrosis [3].

Associations of L 689502 with other chemical compounds


  1. Dose-dependent toxicokinetics of L-689,502, a potent human immunodeficiency virus protease inhibitor, in rats and dogs. Lin, J.H., Chen, I.W., King, J. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  2. HIV-1 protease inhibitory activity of L-694,746, a novel metabolite of L-689,502. Lingham, R.B., Arison, B.H., Colwell, L.F., Hsu, A., Dezeny, G., Thompson, W.J., Garrity, G.M., Gagliardi, M.M., Hartner, F.W., Darke, P.L. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  3. Hepatotoxicity of an HIV protease inhibitor in dogs and rats. Grossman, S.J., Reinford, N., Anderson, C., Eydelloth, R.S., Alberts, D.W., Smith, P.F., Patrick, D.H. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  4. Inhibition of human immunodeficiency virus type-1 replication in macrophages and H9 cells by free or liposome-encapsulated L-689,502, an inhibitor of the viral protease. Pretzer, E., Flasher, D., Düzgüneş, N. Antiviral Res. (1997) [Pubmed]
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