Disease relevance of Tertrodirect Blue F

• The metabolism of a benzidine-based dye, Direct Black 38, a 3,3'-dimethylbenzidine-based dye, Direct Red 2 and a 3,3'-dimethoxybenzidine-based dye, Direct Blue 15 has been studied both in pure cultures of anaerobic bacteria and in bacterial suspensions derived from the intestinal contents of the rat [1].
• (2 species), Clostridium clostridiiforme, a Butyrivibrio sp., a Bacteroides sp., Clostridium paraputrificum, Clostridium nexile, and a Clostridium sp. The average rate of reduction of Direct Blue 15 dye (a dimethoxybenzidine-based dye) in these strains ranged from 16 to 135 nmol of dye per min per mg of protein [2].
• Thirteen-week toxicity studies of 3,3'-dimethoxybenzidene and C.I. Direct Blue 15 in the Fischer 344 rat [3].

High impact information on Tertrodirect Blue F

• Using an acidified solution of Niagara sky blue 6B, granules in mature granulocytic cells from peripheral blood and bone marrow stained bright blue to blue-green [4].
• Supplementary information is also presented concerning hydrolysis of diacetylated metabolites and the stability of Direct Red 2 and Direct Blue 15 in rat, hamster and human urine [5].
• Excretion profiles based on parallel HPLC and radioassays of feces from rats dosed with 14C-labeled Direct Blue 15 and Direct Red 2 are presented [6].
• Microelectrodes containing 9% Niagara Sky Blue dye were used to record and electrophoretically mark cells in the guinea pig organ of Corti [7].

References