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Chemical Compound Review

Tolidine     4-(4-amino-3-methyl-phenyl)- 2-methyl-aniline

Synonyms: Bianisidine, Diaminotolyl, Orthotolidine, Diaminoditolyl, o-Tolidine, ...
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Disease relevance of o-Tolidine

  • The number of revertants was increased in the presence of S9 mix by o-tolidine in the Salmonella typhimurium strains TA98 and TA1538, and by TDDM in strains TA98 and TA100 [1].
  • It is of importance to early recognize any acutely ill patient as having rhabdomyolysis syndrome when there is elevation of muscle enzymes, hypocalcemic seizure, positive orthotolidine reaction of urine strip while negative finding of red blood cell [2].

High impact information on o-Tolidine


Chemical compound and disease context of o-Tolidine


Biological context of o-Tolidine


Anatomical context of o-Tolidine


Associations of o-Tolidine with other chemical compounds


Gene context of o-Tolidine


Analytical, diagnostic and therapeutic context of o-Tolidine


  1. Mutagenicity studies with o-tolidine and 4,4'-tetramethyldiaminodiphenylmethane. Waalkens, D.H., Joosten, H.F., Yih, T.D., Hoekstra, A. Mutat. Res. (1981) [Pubmed]
  2. Rhabdomyolysis syndrome in children: report of three cases. Huang, S.J., Yen, D.C., Tsau, Y.K., Tsai, W.S., Chen, C.H. Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui (1993) [Pubmed]
  3. A novel form of congenital dyserythropoietic anemia associated with deficiency of erythroid CD44 and a unique blood group phenotype [In(a-b-), Co(a-b-)]. Parsons, S.F., Jones, J., Anstee, D.J., Judson, P.A., Gardner, B., Wiener, E., Poole, J., Illum, N., Wickramasinghe, S.N. Blood (1994) [Pubmed]
  4. How accurate is the determination of blood in gastric juice? Comparison of peroxidase and porphyrin methods. Woods, K.L., Kiefe, C., Graham, D.Y. Aliment. Pharmacol. Ther. (1996) [Pubmed]
  5. Intragastric prostaglandin E2 and the prevention of gastrointestinal hemorrhage in ICU patients. van Essen, H.A., van Blankenstein, M., Wilson, J.H., van den Berg, B., Bruining, H.A. Crit. Care Med. (1985) [Pubmed]
  6. Identification by thin-layer chromatography of dyestuffs based on benzidine, o-tolidine or o-dianisidine in consumer fabric dye products. Pindar, A.G., Tinsley, H.M. The Analyst. (1984) [Pubmed]
  7. Comparison of 7 azo dyes and their azo reduction products in the rat and hamster hepatocyte primary culture/DNA-repair assays. Kornbrust, D.J., Barfknecht, T.R. Mutat. Res. (1984) [Pubmed]
  8. Mutagenicity of some congeners of benzidine in the Salmonella typhimurium assay system. Lazear, E.J., Louie, S.C. Cancer Lett. (1978) [Pubmed]
  9. Hemolysis-in-gel and neutralization tests for determination of antibodies to mumps virus. Grillner, L., Blomberg, J. J. Clin. Microbiol. (1976) [Pubmed]
  10. Effects of presumptive test reagents on the ability to obtain restriction fragment length polymorphism (RFLP) patterns from human blood and semen stains. Hochmeister, M.N., Budowle, B., Baechtel, F.S. J. Forensic Sci. (1991) [Pubmed]
  11. HRP reacted with the chromogen o-tolidine produces whole-cell reaction product at light and electron microscope levels: negative effects of sucrose and Golgi staining on benzidine reactions. Elberger, A.J., Hester, M.M., Stiles, H. J. Neurosci. Methods (1992) [Pubmed]
  12. A method for myoglobin in cryostat sections of muscle by precipitation with sulfosalicylic acid. Swatland, H.J. Stain technology. (1979) [Pubmed]
  13. Electron microscopic demonstration of neural connections using horseradish peroxidase: a comparison of the tetramethylbenzidine procedure with seven other histochemical methods. Carson, K.A., Mesulam, M.M. J. Histochem. Cytochem. (1982) [Pubmed]
  14. Differential serum protein binding of benzidine- and benzidine-congener based dyes and their derivatives. Emmett, M., Cerniglia, C.E., Crowle, A.J. Arch. Toxicol. (1985) [Pubmed]
  15. A study of the sensitivity and specificity of four presumptive tests for blood. Cox, M. J. Forensic Sci. (1991) [Pubmed]
  16. Rhabdomyolysis and acute renal failure. Thomas, M.A., Ibels, L.S. Australian and New Zealand journal of medicine. (1985) [Pubmed]
  17. Rhabdomyolysis in diabetic ketoacidosis. Buckingham, B.A., Roe, T.F., Yoon, J.W. Am. J. Dis. Child. (1981) [Pubmed]
  18. Oxidation of benzidine and its derivatives by thyroid peroxidase. Sentchouk, V.V., Grintsevich, E.E. Biochemistry Mosc. (2004) [Pubmed]
  19. Azo reduction of trypan blue to a known carcinogen by a cell-free extract of a human intestinal anaerobe. Hartman, C.P., Fulk, G.E., Andrews, A.W. Mutat. Res. (1978) [Pubmed]
  20. Effect of dietary factors on the detection of fecal occult blood in cats. Tuffli, S.P., Gaschen, F., Neiger, R. J. Vet. Diagn. Invest. (2001) [Pubmed]
  21. Reliability of chemical tests for fecal occult blood in hospitalized patients. Morris, D.W., Hansell, J.R., Ostrow, J.D., Lee, C.S. The American journal of digestive diseases. (1976) [Pubmed]
  22. The effect of detergents on chemical occult blood test. Imafuku, Y., Yoshida, H., Yoshida, S. Fukushima journal of medical science. (1999) [Pubmed]
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