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Chemical Compound Review

Desiclovir     2-[(2-aminopurin-9- yl)methoxy]ethanol

Synonyms: DESCICLOVIR, Desciclovirum, Deoxyacyclovir, SureCN2028, BW-A515U, ...
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Disease relevance of DESCICLOVIR


High impact information on DESCICLOVIR


Associations of DESCICLOVIR with other chemical compounds

  • On the basis of these results, it was apparent that the success of 6- deoxyacyclovir as a prodrug in vivo would depend upon how well its desired activation by xanthine oxidase competed with the nonactivating oxidations by aldehyde oxidase [1].

Analytical, diagnostic and therapeutic context of DESCICLOVIR


  1. 6-Deoxyacyclovir: a xanthine oxidase-activated prodrug of acyclovir. Krenitsky, T.A., Hall, W.W., de Miranda, P., Beauchamp, L.M., Schaeffer, H.J., Whiteman, P.D. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  2. A pilot study of BW A515U (6-deoxyacyclovir) in chronic hepatitis B virus infection. Weller, I.V., Tedder, R.S., Karayiannis, P., Thomas, H.C., Fiddian, A.P. J. Hepatol. (1986) [Pubmed]
  3. Open study of 2-amino-9-(hydroxyethoxymethyl)-9H-purine (desciclovir) in the treatment of herpes zoster. Peterslund, N.A., Esmann, V., Geil, J.P., Petersen, C.M., Mogensen, C.E. J. Antimicrob. Chemother. (1987) [Pubmed]
  4. Antivirals for the treatment of herpesvirus infections. De Clercq, E. J. Antimicrob. Chemother. (1993) [Pubmed]
  5. Efficacy of desciclovir in the treatment of Epstein-Barr virus infection in oral hairy leukoplakia. Greenspan, D., De Souza, Y.G., Conant, M.A., Hollander, H., Chapman, S.K., Lennette, E.T., Petersen, V., Greenspan, J.S. J. Acquir. Immune Defic. Syndr. (1990) [Pubmed]
  6. Pharmacokinetics and tolerance of desciclovir, a prodrug of acyclovir, in healthy human volunteers. Petty, B.G., Whitley, R.J., Liao, S., Krasny, H.C., Rocco, L.E., Davis, L.G., Lietman, P.S. Antimicrob. Agents Chemother. (1987) [Pubmed]
  7. Desciclovir permeation of the human erythrocyte membrane by nonfacilitated diffusion. Domin, B.A., Mahony, W.B., Zimmerman, T.P. Biochem. Pharmacol. (1991) [Pubmed]
  8. Preparative electrochemical reduction of 2-amino-6-chloropurine and synthesis of 6-deoxyacyclovir, a fluorescent substrate of xanthine oxidase and a prodrug of acyclovir. Kusmierek, J.T., Czochralska, B., Johansson, N.G., Shugar, D. Acta Chem. Scand., B, Org. Chem. Biochem. (1987) [Pubmed]
  9. Radioimmunoassay for desciclovir, 2-[(2-amino-9H-purin-9-yl)methoxy]ethanol, a prodrug for the antiviral acyclovir. Quinn, R.P., Gerald, L., Tadepalli, S. Journal of immunoassay. (1987) [Pubmed]
  10. Management of oral lesions in HIV-positive patients. Baccaglini, L., Atkinson, J.C., Patton, L.L., Glick, M., Ficarra, G., Peterson, D.E. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (2007) [Pubmed]
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