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Chemical Compound Review

SureCN7859156     N'-(4-chlorophenyl)sulfonyl- N-[(1S)-2...

Synonyms: Ici 200880, Ici 200,880, AC1L1S7H, AC1Q3O4D, 105080-50-0
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Disease relevance of Ici 200880

  • In the present study, we examined the effects of tissue-plasminogen activator (t-PA, 1 mg/kg over 20 minutes) given intravenously with either saline or a leukocyte elastase inhibitor (ICI 200,880, 5 mg/kg) in dogs with electrically-induced coronary artery thrombosis [1].

High impact information on Ici 200880


Anatomical context of Ici 200880


Associations of Ici 200880 with other chemical compounds

  • Previously we had shown that tripeptidyl trifluoromethyl ketones (TFMKs) possessing an N-terminal diarylacylsulfonamide, such as ICI 200,880 and ICI 200,355, displayed unparalleled protection against the lung damage induced by human neutrophil elastase (HNE) when the inhibitors were administered intratracheally [5].

Analytical, diagnostic and therapeutic context of Ici 200880


  1. Leukocyte elastase inhibition and t-PA-induced coronary artery thrombolysis in dogs: beneficial effects on myocardial histology. Nicolini, F.A., Mehta, J.L., Nichols, W.W., Donnelly, W.H., Luostarinen, R., Saldeen, T.G. Am. Heart J. (1991) [Pubmed]
  2. Synthetic inhibitors of elastase. Edwards, P.D., Bernstein, P.R. Medicinal research reviews. (1994) [Pubmed]
  3. Neutrophil elastase inhibitor ICI 200,880 protects against attenuation of coronary flow reserve and myocardial dysfunction following temporary coronary artery occlusion in the dog. Mehta, J.L., Nichols, W.W., Nicolini, F.A., Hendricks, J., Donnelly, W.H., Saldeen, T.G. Cardiovasc. Res. (1994) [Pubmed]
  4. A specific radioimmunoassay for the measurement of ICI 200,880, an elastase inhibitor, in human serum. Davis, P.C., Wildonger, R.A., Veale, H.S. Journal of pharmaceutical and biomedical analysis. (1993) [Pubmed]
  5. Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase. Edwards, P.D., Andisik, D.W., Bryant, C.A., Ewing, B., Gomes, B., Lewis, J.J., Rakiewicz, D., Steelman, G., Strimpler, A., Trainor, D.A., Tuthill, P.A., Mauger, R.C., Veale, C.A., Wildonger, R.A., Williams, J.C., Wolanin, D.J., Zottola, M. J. Med. Chem. (1997) [Pubmed]
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