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Chemical Compound Review

CCRIS 8142     N'-(4-bromophenyl)sulfonyl-N- [(2S)-3...

Synonyms: CHEBI:179437, AC1L3TUA, Ici-200,355, LS-171951, ICI 200355, ...
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Disease relevance of ICI 200355


High impact information on ICI 200355

  • We have obtained identical results with alpha1-antitrypsin, alpha2m, recombinant secretory leukocyte proteinase inhibitor, and ICI 200,355, and we have found that phagocyte-derived oxidants are not required for the genesis of this catalytic activity [2].
  • ICI 200,355, a selective inhibitor of neutrophil elastase, prevented LTB(4)-induced nasal secretion and lysozyme secretion, but it had no effect on neutrophil recruitment [3].
  • Pretreatment with the selective neutrophil elastase inhibitor ICI 200,355 also prevented ovalbumin-induced goblet cell degranulation, implicating elastase [4].
  • RESULTS--When preincubated with neutrophils both rSLPI and r alpha 1-PI were effective inhibitors of fibronectin degradation although n alpha 1-PI and ICI 200,355 were less effective [5].
  • This effect was largely (83%; P<0.02) inhibited by ICI 200,355, a specific inhibitor of neutrophil elastase [6].

Biological context of ICI 200355


Anatomical context of ICI 200355


Associations of ICI 200355 with other chemical compounds


Gene context of ICI 200355


  1. Inhibition of human neutrophil elastase by ICI 200,355. Sommerhoff, C.P., Krell, R.D., Williams, J.L., Gomes, B.C., Strimpler, A.M., Nadel, J.A. Eur. J. Pharmacol. (1991) [Pubmed]
  2. Quantum proteolysis resulting from release of single granules by human neutrophils: a novel, nonoxidative mechanism of extracellular proteolytic activity. Liou, T.G., Campbell, E.J. J. Immunol. (1996) [Pubmed]
  3. LTB(4)-induced nasal gland serous cell secretion mediated by neutrophil elastase. Cardell, L.O., Agustí, C., Takeyama, K., Stjärne, P., Nadel, J.A. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  4. Goblet cell degranulation after antigen challenge in sensitized guinea pigs. Role of neutrophils. Agusti, C., Takeyama, K., Cardell, L.O., Ueki, I., Lausier, J., Lou, Y.P., Nadel, J.A. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  5. Potential role of recombinant secretory leucoprotease inhibitor in the prevention of neutrophil mediated matrix degradation. Llewellyn-Jones, C.G., Lomas, D.A., Stockley, R.A. Thorax (1994) [Pubmed]
  6. Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis. Leiper, K., Campbell, B.J., Jenkinson, M.D., Milton, J., Yu, L.G., Democratis, J., Rhodes, J.M. Clin. Sci. (2001) [Pubmed]
  7. Elastase contributes to antigen-induced mucociliary dysfunction in ovine airways. O'Riordan, T.G., Otero, R., Mao, Y., Lauredo, I., Abraham, W.M. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  8. Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors. Schuster, A., Fahy, J.V., Ueki, I., Nadel, J.A. Eur. Respir. J. (1995) [Pubmed]
  9. Biologic characterization of ICI 200,880 and ICI 200,355, novel inhibitors of human neutrophil elastase. Williams, J.C., Falcone, R.C., Knee, C., Stein, R.L., Strimpler, A.M., Reaves, B., Giles, R.E., Krell, R.D. Am. Rev. Respir. Dis. (1991) [Pubmed]
  10. Neutrophil-dependent goblet cell degranulation: role of membrane-bound elastase and adhesion molecules. Takeyama, K., Agustí, C., Ueki, I., Lausier, J., Cardell, L.O., Nadel, J.A. Am. J. Physiol. (1998) [Pubmed]
  11. Mucus hypersecretion in bronchiectasis. The role of neutrophil proteases. Fahy, J.V., Schuster, A., Ueki, I., Boushey, H.A., Nadel, J.A. Am. Rev. Respir. Dis. (1992) [Pubmed]
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