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Chemical Compound Review

Aureotan     gold(+1) cation; (3R,4S,5S,6R)-3,4,5...

Synonyms: Aurumine, AuTG, AC1L9RYR, AC1O0ULP, (1-Thio-D-glucopyranosato-O2,-S1)gold
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High impact information on (3R,4S,5R,6R)-2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol

  • ATG blocks PKCiota-dependent signaling to Rac1 and inhibits transformed growth of NSCLC cells [1].
  • ATG-mediated inhibition of transformation is relieved by expression of constitutively active Rac1, consistent with a mechanism at the level of the interaction between PKCiota and Par6 [1].
  • The mol wt of the affinity-labeled proteins in various liver microsomal preparations ranged between 28-36 kilodaltons (kDa), and the ATG concentrations necessary for the inhibition of affinity labeling of microsomes with [125I]bromoacetyl T3 were comparable to those required for inhibition of the enzyme activity in all species except the pig [2].
  • The pig liver microsomes demonstrated a dominant affinity-labeled 36-kDa band, but much higher ATG concentrations (micromolar) were required for inhibition of affinity labeling [2].
  • By contrast, GLS mRNA levels in IL-1beta-stimulated FLSs were reduced by treatment with aurothioglucose (AuTG) and dexamethasone (DEX) [3].

Anatomical context of (3R,4S,5R,6R)-2-mercapto-6-methylol-tetrahydropyran-3,4,5-triol


  1. A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells. Stallings-Mann, M., Jamieson, L., Regala, R.P., Weems, C., Murray, N.R., Fields, A.P. Cancer Res. (2006) [Pubmed]
  2. A study of the characteristics of hepatic iodothyronine 5'-monodeiodinase in various vertebrate species. Santini, F., Chopra, I.J., Hurd, R.E., Teco, G.N. Endocrinology (1992) [Pubmed]
  3. The inhibitory effect of disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytes. Kusabe, T., Waguri-Nagaya, Y., Tanikawa, T., Aoyama, M., Fukuoka, M., Kobayashi, M., Otsuka, T., Asai, K. Rheumatol. Int. (2005) [Pubmed]
  4. Unique properties of auranofin as a potential anti-rheumatic drug. Barrett, M.L., Lewis, G.P. Agents Actions (1986) [Pubmed]
  5. The effect of adipose cell size on the measurement of GLUT 4 in white adipose tissue of obese mice. Fabres-Machado, U., Saito, M. Braz. J. Med. Biol. Res. (1995) [Pubmed]
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