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Chemical Compound Review

Aurothiomalate     gold(+1) cation; 4-hydroxy-4-oxo-2...

Synonyms: AR-1J1352, AC1L34U3, gold(1+) 3-carboxy-2-sulfanylpropanoate, gold(1+); 4-hydroxy-4-oxo-2-sulfanylbutanoate
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Disease relevance of Monomercaptosuccinic acid


High impact information on Monomercaptosuccinic acid


Chemical compound and disease context of Monomercaptosuccinic acid


Biological context of Monomercaptosuccinic acid


Anatomical context of Monomercaptosuccinic acid


Associations of Monomercaptosuccinic acid with other chemical compounds


Gene context of Monomercaptosuccinic acid


Analytical, diagnostic and therapeutic context of Monomercaptosuccinic acid


  1. HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. Wooley, P.H., Griffin, J., Panayi, G.S., Batchelor, J.R., Welsh, K.I., Gibson, T.J. N. Engl. J. Med. (1980) [Pubmed]
  2. Activation of gold-reactive T lymphocytes in rheumatoid arthritis patients treated with gold. Verwilghen, J., Kingsley, G.H., Gambling, L., Panayi, G.S. Arthritis Rheum. (1992) [Pubmed]
  3. Neurologic complications induced by gold treatment. Schlumpf, U., Meyer, M., Ulrich, J., Friede, R.L. Arthritis Rheum. (1983) [Pubmed]
  4. Association of IgE antibodies to sodium aurothiomalate and adverse reactions to chrysotherapy for rheumatoid arthritis. Bretza, J., Wells, I., Novey, H.S. Am. J. Med. (1983) [Pubmed]
  5. Inhibition of mycoplasma-induced lymphocyte activation by sodium aurothiomalate. Naot, Y., Merchav, S. Infect. Immun. (1978) [Pubmed]
  6. The antirheumatic drug disodium aurothiomalate inhibits CD4+ T cell recognition of peptides containing two or more cysteine residues. Griem, P., Takahashi, K., Kalbacher, H., Gleichmann, E. J. Immunol. (1995) [Pubmed]
  7. Effect of gold compounds on the activity of adenylyl cyclase in human lymphocyte membranes. Lazarevic, M.B., Yan, K., Swedler, W.I., Rasenick, M.M., Skosey, J.L. Arthritis Rheum. (1992) [Pubmed]
  8. Down-regulation of IL-1 beta biosynthesis by inducers of the heat-shock response. Schmidt, J.A., Abdulla, E. J. Immunol. (1988) [Pubmed]
  9. Methyl ester of N-formylmethionyl-leucyl-phenylalanine: chemotactic responses of human blood monocytes and inhibition of gold compounds. Ho, P.P., Young, A.L., Southard, G.L. Arthritis Rheum. (1978) [Pubmed]
  10. Gold-containing drugs and the control of proteolytic enzymes. Rohozková, D., Steven, F.S. Br. J. Pharmacol. (1983) [Pubmed]
  11. Measurement of 'free' gold in patients receiving disodium aurothiomalate and the association of high free to total gold levels with toxicity. Heath, M.J. Ann. Rheum. Dis. (1988) [Pubmed]
  12. Skin rashes and stomatitis due to parenteral treatment of rheumatoid arthritis with sodium aurothiomalate. Svensson, A., Theander, J. Ann. Rheum. Dis. (1992) [Pubmed]
  13. Decreased level of antibodies against Helicobacter pylori in patients with rheumatoid arthritis receiving intramuscular gold. Janssen, M., Dijkmans, B.A., Vandenbroucke, J.P., van Duijn, W., Peña, A.S., Lamers, C.B. Ann. Rheum. Dis. (1992) [Pubmed]
  14. Paradoxical derepression of collagenase gene expression by the antirheumatic gold compound aurothiomalate. Makino, Y., Tanaka, H., Makino, I. Mol. Pharmacol. (1994) [Pubmed]
  15. Zinc ions antagonize the inhibitory effect of aurothiomalate on glucocorticoid receptor function at physiological concentrations. Tanaka, H., Makino, Y., Dahlman-Wright, K., Gustafsson, J.A., Okamoto, K., Makino, I., Wright KD [corrected to Dahlman-Wright, K. Mol. Pharmacol. (1995) [Pubmed]
  16. Neutrophil chemotaxis in rheumatoid arthritis. Effect of D-penicillamine, gold salts, and levamisole. Mowat, A.G. Ann. Rheum. Dis. (1978) [Pubmed]
  17. Gold complexes and activation of human polymorphonuclear leukocytes. Dissociation of changes in membrane potential and oxidative burst. Rudkowski, R., Ziegler, J.B., Graham, G.G., Joulianos, G. Biochem. Pharmacol. (1992) [Pubmed]
  18. Mechanisms of aurothiomalate-Cys2His2 zinc finger interactions. Larabee, J.L., Hocker, J.R., Hanas, J.S. Chem. Res. Toxicol. (2005) [Pubmed]
  19. Aurosome formation in articular tissues after parenteral administration of gold. Oryschak, A.F., Ghadially, F.N. J. Pathol. (1976) [Pubmed]
  20. Experimental gold nephropathy in guinea pigs: detection of autoantibodies to renal tubular antigens. Ueda, S., Wakashin, M., Wakashin, Y., Yoshida, H., Iesato, K., Mori, T., Mori, Y., Akikusa, B., Okuda, K. Kidney Int. (1986) [Pubmed]
  21. Effect of sodium aurothiomalate on carrageenan induced inflammation of the air pouch in mice. Sin, Y.M., Wong, M.K. Ann. Rheum. Dis. (1992) [Pubmed]
  22. Action of sodium aurothiomalate on erythrocyte membrane. Campbell, J.M., Reglinski, J., Smith, W.E., Porter, D., Sturrock, R.D. Ann. Rheum. Dis. (1992) [Pubmed]
  23. A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells. Stallings-Mann, M., Jamieson, L., Regala, R.P., Weems, C., Murray, N.R., Fields, A.P. Cancer Res. (2006) [Pubmed]
  24. Methotrexate in rheumatoid arthritis. An update. Bannwarth, B., Labat, L., Moride, Y., Schaeverbeke, T. Drugs (1994) [Pubmed]
  25. Monocyte superoxide anion production in rheumatoid arthritis: preliminary evidence for enhanced rates of superoxide anion production by monocytes from patients receiving penicillamine, sodium aurothiomalate and corticosteroids. Hurst, N.P., Bessac, B., Nuki, G. Ann. Rheum. Dis. (1984) [Pubmed]
  26. Fate of the gold and the thiomalate part after intramuscular administration of aurothiomalate to mice. Jellum, E., Munthe, E., Guldal, G., Aaseth, J. Ann. Rheum. Dis. (1980) [Pubmed]
  27. The in vivo effect of triethylphosphine gold (auranofin), sodium aurothiomalate and azathioprine on natural killer cell activity of patients with rheumatoid arthritis. Abom, B., Pedersen, B.K. Clinical and experimental rheumatology. (1987) [Pubmed]
  28. Sodium aurothiomalate inhibits T cell responses to interleukin-2. Harth, M., Cousin, K., McCain, G.A. Immunopharmacology and immunotoxicology. (1988) [Pubmed]
  29. The effect of second-line antirheumatic drugs on interleukin-8 mRNA synthesis and protein secretion in human endothelial cells. Deleuran, B., Kristensen, M., Paludan, K., Zachariae, C., Larsen, C.G., Zachariae, E., Thestrup-Pedersen, K. Cytokine (1992) [Pubmed]
  30. Effects of antirheumatic gold salts on cytokine-induced neutrophil-dependent cytotoxicity for human endothelial cells. Bratt, J., Palmblad, J. J. Investig. Med. (2000) [Pubmed]
  31. Effects of gold on the production of and response to human interleukin-1. Drakes, M.L., Harth, M., Galsworthy, S.B., McCain, G.A. J. Rheumatol. (1987) [Pubmed]
  32. A double-blind trial of high versus conventional dosages of gold salts for rheumatoid arthritis. Furst, D.E., Levine, S., Srinivasan, R., Metzger, A.L., Bangert, R., Paulus, H.E. Arthritis Rheum. (1977) [Pubmed]
  33. Cultured human cells can acquire resistance to the antiproliferative effect of sodium aurothiomalate. Glennås, A., Rugstad, H.E. Ann. Rheum. Dis. (1986) [Pubmed]
  34. Sodium aurothiomalate does not block interleukin 1 production in rabbits. Zurovsky, Y., Laburn, H.P., Mitchell, D., Ruck, A. Ann. Rheum. Dis. (1988) [Pubmed]
  35. A three year follow up of patients allocated to placebo, or oral or injectable gold therapy for rheumatoid arthritis. Capell, H.A., Lewis, D., Carey, J. Ann. Rheum. Dis. (1986) [Pubmed]
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