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Chemical Compound Review:

Actamol 1-phenylethylhydrazine

Synonyms: Actomol, Mebanazina, Mebanazine, Mebenazine, Mebanazinum, ...

Brambilla, G. et al., Cox, B. et al., Garcha, G. et al.

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High impact information on Actomol

[14C]-PEA and phenylacetic acid (PAA) accounted for approximately 85% of radioactivity recovered in blood from control cats or those pretreated with deprenyl or mebanazine [1].
Experiments with, mebanazine, reserpine, diethyldithiocarbamate, and p-chlorophenylalanine suggest that the tremorgenic action of amantadine is influenced by a balance between three putative central nervous system (CNS) transmitters: noradrenaline, dopamine and 5-hydroxytryptamine (5-HT) [2].
(2) All the compounds except mebanazine (which was no longer available for testing) were weak inducers of sister chromatid exchanges in bone marrow cells of mice treated ip [3].
Five antidepressant agents (monoamine oxidase inhibitors) having a hydrazino group--phenelzine, nialamide, mebanazine, isocarboxazid, and iproniazid--were assayed in four in vivo or in vitro short-term tests predictive of the potential carcinogenicity of chemicals [3].

References

[14C]-beta-phenethylamine, its distribution after administration by various routes to cats, and the effects of monoamine oxidase inhibitors. Garcha, G., Imrie, P.R., Marley, E., Thomas, D.V. Br. J. Pharmacol. (1985) [Pubmed]
Amantadin e tremor, a 5-hydroxytryptamine-mediated response? Cox, B., Tha, S.J. Eur. J. Pharmacol. (1975) [Pubmed]
Genotoxic activity of five antidepressant hydrazines in a battery of in vivo and in vitro short-term tests. Brambilla, G., Cavanna, M., Faggin, P., Pino, A., Robbiano, L., Bennicelli, C., Zanacchi, P., Camoirano, A., De Flora, S. Journal of toxicology and environmental health. (1982) [Pubmed]

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