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Chemical Compound Review:

Tribehenin 1,3-didocosanoyloxypropan-2-yl docosanoate

Synonyms: Tridocosanoin, Compritol 888, CHEMBL2104418, T7904_SIGMA, ANW-42123, ...

Furlanetto, S. et al., Jores, K. et al., N'Diaye, A. et al., Hariharan, M. et al., Mirghani, A. et al., et al.

Li, Hu, Deng, Su, Xu, Liu, Hariharan, Wowchuk, Nkansah, Gupta,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Glyceryl tribehenate

The structures of SLN and NLC based on glyceryl behenate and medium chain triglycerides were characterized by photon correlation spectroscopy (PCS) and laser diffraction (LD), field-flow fractionation (FFF) with multi-angle light scattering detection (MALS), and cryo transmission electron microscopy (cryo TEM) [1].
In vitro controlled release of sodium ferulate from Compritol 888 ATO-based matrix tablets [2].
Experimental design was utilized to simultaneously investigate the effect of varying the type of diluent (insoluble Calcium phosphate or water-soluble arabic gum) and the diluent/matrix ratio on the drug release behaviour from both lipophilic (glyceryl behenate, Compritol) or hydrophilic (hydroxypropylmethylcellulose) matrix tablets [3].
Finally, the minor difference of lubricant capacity between Compritol HD5 ATO and Compritol 888 ATO has no consequence in compression practice [4].
Two different SLN formulations were prepared following the high-pressure homogenization technique using Compritol 888 ATO as lipid and Poloxamer 188 or Miranol Ultra C32 as surfactants [5].

Associations of Glyceryl tribehenate with other chemical compounds

Comparative study of the lubricant performance of Compritol HD5 ATO and Compritol 888 ATO: effect of polyethylene glycol behenate on lubricant capacity [4].
The effect of sodium alginate concentration, drug: Compritol 888 weight ratio and CaCl2 concentration on drug content (%), time for 50% and 80% of the drug to be released, and mean dissolution time (MDT) were evaluated with analysis of variance (ANOVA) [6].
The authors used mixture experimental design to study the effect of formulation components using diclofenac sodium as the model drug substance and varying relative amounts of microcrystalline cellulose (Avicel), hydroxypropyl methylcellulose (HPMC), and glyceryl behenate (Compritol) [7].
The other conventional lubricants such as magnesium stearate (MGST), stearic acid (STAC), and glyceryl behenate (COMP) were also tested along with HBN [8].

Analytical, diagnostic and therapeutic context of Glyceryl tribehenate

Measurements performed by densimetry and Raman spectroscopy confirm the idea of intact glyceryl behenate lattices in spite of oil loading [9].

References

Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy. Jores, K., Mehnert, W., Drechsler, M., Bunjes, H., Johann, C., Mäder, K. Journal of controlled release : official journal of the Controlled Release Society. (2004) [Pubmed]
In vitro controlled release of sodium ferulate from Compritol 888 ATO-based matrix tablets. Li, F.Q., Hu, J.H., Deng, J.X., Su, H., Xu, S., Liu, J.Y. International journal of pharmaceutics. (2006) [Pubmed]
Study of formulation variables influencing the drug release rate from matrix tablets by experimental design. Furlanetto, S., Cirri, M., Maestrelli, F., Corti, G., Mura, P. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2006) [Pubmed]
Comparative study of the lubricant performance of Compritol HD5 ATO and Compritol 888 ATO: effect of polyethylene glycol behenate on lubricant capacity. N'Diaye, A., Jannin, V., Bérard, V., Andrès, C., Pourcelot, Y. International journal of pharmaceutics. (2003) [Pubmed]
Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: preparation and characterization. Lai, F., Wissing, S.A., Müller, R.H., Fadda, A.M. AAPS PharmSciTech [electronic resource]. (2006) [Pubmed]
Formulation and release behavior of diclofenac sodium in Compritol 888 matrix beads encapsulated in alginate. Mirghani, A., Idkaidek, N.M., Salem, M.S., Najib, N.M. Drug development and industrial pharmacy. (2000) [Pubmed]
Effect of formulation composition on the properties of controlled release tablets prepared by roller compaction. Hariharan, M., Wowchuk, C., Nkansah, P., Gupta, V.K. Drug development and industrial pharmacy. (2004) [Pubmed]
Evaluation of hexagonal boron nitride as a new tablet lubricant. Turkoglu, M., Sahin, I., San, T. Pharmaceutical development and technology. (2005) [Pubmed]
Solid lipid nanoparticles (SLN) and oil-loaded SLN studied by spectrofluorometry and Raman spectroscopy. Jores, K., Haberland, A., Wartewig, S., Mäder, K., Mehnert, W. Pharm. Res. (2005) [Pubmed]

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