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Chemical Compound Review

Diopside     calcium; dihydroxy-oxo-silane; magnesium

Synonyms: AC1O3SRU, Camg(sio3)2, 14483-19-3, Diopside (CaMg(SiO3)2), calcium; dihydroxy(oxo)silane; magnesium
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Disease relevance of Diopside


High impact information on Diopside

  • A silicate inclusion within the IIIA meteorite Puente del Zacate consisting of olivine (Fa4), low-calcium pyroxene (Fs6Wo1), chromium diopside (Fs3Wo47), plagioclase (An14Or4), graphite, troilite, chromite, daubreelite, and iron metal resembles inclusions in IAB iron meteorites [2].
  • Specimens were prepared in three experiments: (1) Granular diopside was immersed in simulated body fluid (SBF); (2) granular diopside was implanted into a cavity in rabbit bone; and (3) a diopside dental root implant was implanted into a Japanese monkey [3].
  • By thermal treatments of G13, a glass-ceramic (GC13) containing apatite, diopside, althausite and akermanite as crystalline phases was developed [4].
  • In order to clarify the biocompatibility of Diopside, the cytotoxicity of Diopside against the osteogenic cell line MC3T3-E1 and the bone-Diopside interface strength were examined [5].
  • On both the 14th and 21st days of incubation of MC3T3-E1 cells with Diopside, ALP activities were not significantly lower than those of the CTRL [5].

Biological context of Diopside

  • By utilising MSW fly ash from the Shanghai Yuqiao municipal solid waste (MSW) incineration plant as the main raw material, diopside-based glass-ceramics were successfully synthesized in the laboratory by combining SiO(2), MgO and Al(2)O(3) or bottom ash as conditioner of the chemical compositions and TiO(2) as the nucleation agent [6].

Gene context of Diopside

  • Osteogenic cell cytotoxicity and biomechanical strength of the new ceramic Diopside [5].
  • Changes in ionic concentrations were measured using Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), while the pH right at the interface of diopside/PHS were determined with an Ion Sensitive Field Effect Transistor (ISFET-Meter) instruments [7].
  • Spinel and diopside in the CAI cores are 16O-rich (Delta17O up to -20 per thousand), whereas diopside in their outer zones, as well as melilite and anorthite, are 16O-depleted (Delta17O = -8 per thousand to 2 per thousand) [8].

Analytical, diagnostic and therapeutic context of Diopside


  1. Study of diopside ceramics for biomaterials. Nonami, T., Tsutsumi, S. Journal of materials science. Materials in medicine. (1999) [Pubmed]
  2. A silicate inclusion in Puente del Zacate, a IIIA iron meteorite. Olsen, E.J., Davis, A.M., Clayton, R.N., Mayeda, T.K., Moore, C.B., Steele, I.M. Science (1996) [Pubmed]
  3. High-resolution and analytical electron microscopic studies of new crystals induced by a bioactive ceramic (diopside). Miake, Y., Yanagisawa, T., Yajima, Y., Noma, H., Yasui, N., Nonami, T. J. Dent. Res. (1995) [Pubmed]
  4. In vitro bioactivity of glass and glass-ceramics of the 3CaO x P2O5-CaO x SiO2-CaO x MgO x 2SiO2 system. Salinas, A.J., Román, J., Vallet-Regí, M., Oliveira, J.M., Correia, R.N., Fernandes, M.H. Biomaterials (2000) [Pubmed]
  5. Osteogenic cell cytotoxicity and biomechanical strength of the new ceramic Diopside. Kobayashi, T., Okada, K., Kuroda, T., Sato, K. J. Biomed. Mater. Res. (1997) [Pubmed]
  6. Diopside-based glass-ceramics from MSW fly ash and bottom ash. Qian, G., Song, Y., Zhang, C., Xia, Y., Zhang, H., Chui, P. Waste management (New York, N.Y.) (2006) [Pubmed]
  7. Bioactivity of diopside ceramic in human parotid saliva. De Aza, P.N., Luklinska, Z.B., Anseau, M. Journal of biomedical materials research. Part B, Applied biomaterials. (2005) [Pubmed]
  8. Chronology of the early Solar System from chondrule-bearing calcium-aluminium-rich inclusions. Krot, A.N., Yurimoto, H., Hutcheon, I.D., MacPherson, G.J. Nature (2005) [Pubmed]
  9. Press-formable CaO-MgO-SiO(2)-TiO(2)-Ag(2)O glass as a biomaterial. Nonami, T., Tsutsumi, S. J. Biomed. Mater. Res. (2000) [Pubmed]
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